Abstract: Technologies are provided for leveraging machine learning to predict the likelihood of near-future OUD for patients presenting in an emergency department. A model is trained with data corresponding to one or more of: gender, age, prior opioid use disorder diagnosis, prior opioid use disorder events, prior opioids, prior emergency department encounters, prior inpatient encounters, other medications, drug screening tests, hepatitis C tests, tobacco use questionnaires, prior results from medical tests, social history questionnaires, or other diagnoses to predict opioid use disorder risk for a population of patients. Upon receiving information available at an emergency department triage for a patient, the trained model is utilized to predict the opioid use disorder risk for the patient over a predetermined period of time.