Abstract: An optimization control system may receive mass spectra of ions emitted from an ionization emitter toward an inlet of a mass spectrometer and control, based on the mass spectra, an automated motion system to adjust a position of the emitter relative to the inlet.

Abstract: Adjusting compensation voltage (CV) parameters of an ion mobility device is described. In one instance, the CV parameters are adjusted to reflect a different CV range, a number of CV steps, or a CV step size to increase throughput of a mass spectrometer.

Abstract: An optimization control system may receive mass spectra of ions emitted from an ionization emitter toward an inlet of a mass spectrometer and control, based on the mass spectra, an automated motion system to adjust a position of the emitter relative to the inlet.

Abstract: A system comprises: first and second mass spectrometers; at least one liquid chromatograph configured to simultaneously supply a first stream of chromatographic eluate derived from a sample to the first mass spectrometer and a second stream of chromatographic eluate to the second mass spectrometer; and a computer or electronic controller electronically coupled to both of the first and second mass spectrometers and comprising computer-readable instructions operable to: input a mass spectrometric analysis of a chromatographic fraction of the sample obtained by the first mass spectrometer; determine whether an additional mass spectrometric analysis of the chromatographic fraction of the sample is required, based on the mass spectrometric analysis of the chromatographic fraction obtained by the first mass spectrometer; and, if the determination is affirmative, cause the second mass spectrometer to perform, after a time delay, the additional mass spectrometric analysis of the chromatographic fraction of the sample

Abstract: A system comprises: first and second mass spectrometers; at least one liquid chromatograph configured to simultaneously supply a first stream of chromatographic eluate derived from a sample to the first mass spectrometer and a second stream of chromatographic eluate to the second mass spectrometer; and a computer or electronic controller electronically coupled to both of the first and second mass spectrometers and comprising computer-readable instructions operable to: input a mass spectrometric analysis of a chromatographic fraction of the sample obtained by the first mass spectrometer; determine whether an additional mass spectrometric analysis of the chromatographic fraction of the sample is required, based on the mass spectrometric analysis of the chromatographic fraction obtained by the first mass spectrometer; and, if the determination is affirmative, cause the second mass spectrometer to perform, after a time delay, the additional mass spectrometric analysis of the chromatographic fraction of the sample

Abstract: A mass spectrometer includes a collision cell and a system controller. The collision cell includes a plurality of rod pairs configured to generate pseudopotential well through the application of radio frequency potentials to the rod pairs. The collision cell configured to generate a target fragment from a parent ion by colliding the parent ion with one or more gas molecules. The system controller is configured to set a radio frequency amplitude of the radio frequency potentials to a default amplitude; monitor the production of a target fragment ion while adjusting the collision energy; set the collision energy to optimize the production of the target fragment ion; apply a linear full range ramp to the radio frequency amplitude to determine an optimal radio frequency amplitude; and set the radio frequency amplitude to the optimal radio frequency amplitude for the parent ion, target fragment ion pair.

Abstract: A mass spectrometer includes a collision cell and a system controller. The collision cell includes a plurality of rod pairs configured to generate pseudopotential well through the application of radio frequency potentials to the rod pairs. The collision cell configured to generate a target fragment from a parent ion by colliding the parent ion with one or more gas molecules. The system controller is configured to set a radio frequency amplitude of the radio frequency potentials to a default amplitude; monitor the production of a target fragment ion while adjusting the collision energy; set the collision energy to optimize the production of the target fragment ion; apply a linear full range ramp to the radio frequency amplitude to determine an optimal radio frequency amplitude; and set the radio frequency amplitude to the optimal radio frequency amplitude for the parent ion, target fragment ion pair.

Abstract: A mass spectrometer includes a collision cell and a system controller. The collision cell includes a plurality of rod pairs configured to generate pseudopotential well through the application of radio frequency potentials to the rod pairs. The collision cell configured to generate a target fragment from a parent ion by colliding the parent ion with one or more gas molecules. The system controller is configured to set a radio frequency amplitude of the radio frequency potentials to a default amplitude; monitor the production of a target fragment ion while adjusting the collision energy; set the collision energy to optimize the production of the target fragment ion; apply a linear full range ramp to the radio frequency amplitude to determine an optimal radio frequency amplitude; and set the radio frequency amplitude to the optimal radio frequency amplitude for the parent ion, target fragment ion pair.

Abstract: A method of analyzing a sample by high-field asymmetric waveform ion mobility-mass spectrometry (FAIMS-MS) is disclosed. An ion beam containing ions of a plurality N of isomers is directed into a FAIMS device. The compensation voltage (CV) at which the FAIMS device is operated is varied among a plurality M of values. For each of the M CV values, an intensity of the ion beam transmitted by the FAIMS device, or product ions derived therefrom, is measured at a mass-to charge ratio corresponding to the plurality N of isomers. The intensities of each of the plurality N of isomers is determined using a set of linear equations, relating the weighted measured intensity values at each value M of the CV and the intensities of each of the N isomers when the FAIMS device is in a non-separation condition.

Abstract: A method of analyzing a sample by high-field asymmetric waveform ion mobility-mass spectrometry (FAIMS-MS) is disclosed. An ion beam containing ions of a plurality N of isomers is directed into a FAIMS device. The compensation voltage (CV) at which the FAIMS device is operated is varied among a plurality M of values. For each of the M CV values, an intensity of the ion beam transmitted by the FAIMS device, or product ions derived therefrom, is measured at a mass-to charge ratio corresponding to the plurality N of isomers. The intensities of each of the plurality N of isomers is determined using a set of linear equations, relating the weighted measured intensity values at each value M of the CV and the intensities of each of the N isomers when the FAIMS device is in a non-separation condition.

Abstract: A mass spectrometer includes a collision cell and a system controller. The collision cell includes a plurality of rod pairs configured to generate pseudopotential well through the application of radio frequency potentials to the rod pairs. The collision cell configured to generate a target fragment from a parent ion by colliding the parent ion with one or more gas molecules. The system controller is configured to set a radio frequency amplitude of the radio frequency potentials to a default amplitude; monitor the production of a target fragment ion while adjusting the collision energy; set the collision energy to optimize the production of the target fragment ion; apply a linear full range ramp to the radio frequency amplitude to determine an optimal radio frequency amplitude; and set the radio frequency amplitude to the optimal radio frequency amplitude for the parent ion, target fragment ion pair.

Abstract: A mass spectrometer includes a collision cell and a system controller. The collision cell includes a plurality of rod pairs configured to generate pseudopotential well through the application of radio frequency potentials to the rod pairs. The collision cell configured to generate a target fragment from a parent ion by colliding the parent ion with one or more gas molecules. The system controller is configured to set a radio frequency amplitude of the radio frequency potentials to a default amplitude; monitor the production of a target fragment ion while adjusting the collision energy; set the collision energy to optimize the production of the target fragment ion; apply a linear full range ramp to the radio frequency amplitude to determine an optimal radio frequency amplitude; and set the radio frequency amplitude to the optimal radio frequency amplitude for the parent ion, target fragment ion pair.

Abstract: A mass spectrometer includes a collision cell and a system controller. The collision cell includes a plurality of rod pairs configured to generate pseudopotential well through the application of radio frequency potentials to the rod pairs. The collision cell configured to generate a target fragment from a parent ion by colliding the parent ion with one or more gas molecules. The system controller is configured to set a radio frequency amplitude of the radio frequency potentials to a default amplitude; monitor the production of a target fragment ion while adjusting the collision energy; set the collision energy to optimize the production of the target fragment ion; apply a linear full range ramp to the radio frequency amplitude to determine an optimal radio frequency amplitude; and set the radio frequency amplitude to the optimal radio frequency amplitude for the parent ion, target fragment ion pair.

Abstract: The linear relationship between physical mass-to-charge ratio and the location of a mass spectral peak along the DC/RF scan line of a quadrupole mass filter is used to simultaneously identify a known set of calibrants and to determine the correct slope and scaling of the scan line from a full spectrum scan of an uncalibrated instrument. This is achieved by using a method for image feature detection, to find a set of collinear peaks in a two-dimensional image constructed from scaled versions of the mass spectrum. The method for feature detection may include a Hough transform, Radon transform or other machine-vision technique.