Patents by Inventor Benno Radt

Benno Radt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10018823
    Abstract: The invention relates to a control device and to a method for controlling a motorized digital microscope. The control device comprises at least one first module (01) for controlling the hardware, the software and the work flow of the digital microscope during the examination of a specimen. According to the invention, the first module (01) comprises a first input means (02, 16) having force feedback for controlling functions of the digital microscope. In a method according to the invention, data input takes place via a first input means, wherein force feedback is generated via the success or progression of the input.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: July 10, 2018
    Assignee: Carl Zeiss Microscopy GMBH
    Inventors: Wolf Jockusch, Robert Schrem, Peter Weber, Alexander Gaiduk, Dominik Stehr, Benno Radt, Markus Gnauck
  • Patent number: 9733160
    Abstract: The invention is directed to method for positioning and aligning a preferably biological sample in the detection area of the objective of a microscope arrangement. According to the invention, the method mentioned above has the following method steps: a sample is introduced into a transparent medium, preferably agarose gel, which is initially liquid; the medium is changed from the liquid state to the solid state, wherein the sample is fixated within the medium, but the transparency of the medium is retained; the solidified medium is positioned in the microscope arrangement in such a way that the sample enclosed therein is situated in the detection area of the objective. Further, a device is proposed for positioning and aligning a preferably biological sample in the detection area of the objective of a microscope arrangement.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: August 15, 2017
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Wibke Hellmich, Benno Radt, Helmut Lippert, Olaf Selchow, Uwe Wolf, Juergen Haese
  • Patent number: 9697605
    Abstract: A method for the three-dimensional imaging of a sample in which image information from different depth planes of the sample is stored in a spatially resolved manner, and the three-dimensional image of the sample is subsequently reconstructed from this stored image information is provided. A reference structure is applied to the illumination light, at least one fluorescing reference object is positioned next to or in the sample, images of the reference structure of the illumination light, of the reference object are recorded from at least one detection direction and evaluated. The light sheet is brought into an optimal position based on the results and image information of the reference object and of the sample from a plurality of detection directions is stored. Transformation operators are obtained on the basis of the stored image information and the reconstruction of the three-dimensional image of the is based on these transformation operators.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: July 4, 2017
    Assignee: CARL ZEISS MICROSCOPY GMBH
    Inventors: Helmut Lippert, Benno Radt, Michael Kempe, Christian Dietrich
  • Patent number: 8921809
    Abstract: A microscopy device, particularly for use in an imaging fluorescence lifetime microscopy method is provided. The microscopy device comprises an illumination means for generating an illumination beam, an imaging detector for spatially resolved acquisition of an emission radiation emitted by an object to be examined, an illumination beam path between the illumination means and the object to be examined, and a detection beam path between the object to be examined and the detector. The illumination beam path comprises illumination optics which are designed to generate a light sheet of illumination radiation extending transverse to the axis of the illumination beam path, wherein the axis of the detection beam path is oriented substantially perpendicular to a section plane of the light sheet and of the object to be examined. The illumination means comprise a pulsed laser.
    Type: Grant
    Filed: April 4, 2009
    Date of Patent: December 30, 2014
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Helmut Lippert, Christopher Power, Christian Dietrich, Benno Radt
  • Publication number: 20140313312
    Abstract: The invention relates to a digital microscope and to a method for optimizing a work process in such a digital microscope. The digital microscope comprises according to the invention at least one first monitoring sensor for observing a sample (08), a sample table (4), an optics unit (02) or a user, and a monitoring unit. In the method according to the invention, first operating data of the first operating sensor are acquired and analyzed and evaluated in an automated manner in the monitoring unit, in order to generate control data and to use said data for controlling the work process of the digital microscope.
    Type: Application
    Filed: April 17, 2014
    Publication date: October 23, 2014
    Applicant: Carl Zeiss Microscopy GmbH
    Inventors: Alexander GAIDUK, Dominik Stehr, Benno Radt, Wolf Jockusch, Enrico Geissler, Johannes Winterot, Markus Gnauck, Johannes Knoblich, Max Funck
  • Publication number: 20140313311
    Abstract: The invention relates to a control device and to a method for controlling a motorized digital microscope. The control device comprises at least one first module (01) for controlling the hardware, the software and the work flow of the digital microscope during the examination of a specimen. According to the invention, the first module (01) comprises a first input means (02, 16) having force feedback for controlling functions of the digital microscope. In a method according to the invention, data input takes place via a first input means, wherein force feedback is generated via the success or progression of the input.
    Type: Application
    Filed: April 16, 2014
    Publication date: October 23, 2014
    Applicant: Carl Zeiss Microscopy GmbH
    Inventors: Wolf JOCKUSCH, Robert Schrem, Peter Weber, Alexander GAIDUK, Dominik Stehr, Benno Radt, Markus Gnauck
  • Publication number: 20140202265
    Abstract: The invention is directed to method for positioning and aligning a preferably biological sample in the detection area of the objective of a microscope arrangement. According to the invention, the method mentioned above has the following method steps: a sample is introduced into a transparent medium, preferably agarose gel, which is initially liquid; the medium is changed from the liquid state to the solid state, wherein the sample is fixated within the medium, but the transparency of the medium is retained; the solidified medium is positioned in the microscope arrangement in such a way that the sample enclosed therein is situated in the detection area of the objective. Further, a device is proposed for positioning and aligning a preferably biological sample in the detection area of the objective of a microscope arrangement.
    Type: Application
    Filed: December 18, 2013
    Publication date: July 24, 2014
    Applicant: Carl Zeiss Microscopy GmbH
    Inventors: Wibke HELLMICH, Benno RADT, Helmut LIPPERT, Olaf SELCHOW, Uwe WOLF, Juergen HAESE
  • Patent number: 8699133
    Abstract: A sample holding system for a microscope, including a sample chamber which has an upper opening and is filled with an immersion liquid, and in which a sample embedded in a transparent embedding compound is placed in a holder. Translatory movement of the sample in relation to a detection objective of the microscope, and rotating the sample about an essentially vertical rotational axis in a plane forming an angle different from zero with the optical axis of the detection objective is included. Rotating the sample includes a rotational drive provided with a magnetic coupling or a belt drive and/or toothed wheel rotational drive arranged above the sample chamber.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: April 15, 2014
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Helmut Lippert, Christopher Power, Christian Dietrich, Benno Radt
  • Patent number: 8547634
    Abstract: The invention is directed to an optical arrangement for photomanipulation of a sample comprising a sample holder for receiving the sample, an illumination device comprising an illumination light source and an illumination beam path for illuminating the sample with a light sheet. It further comprises a detection device for detecting light that is radiated from the sample and imaging optics which image the sample on the detection device by means of an imaging objective in an imaging beam path, wherein the light sheet is substantially planar in the focus of the imaging objective, and wherein the imaging objective has an optical axis which intersects the plane of the light sheet at an angle different from zero. Further, the arrangement also has means for photomanipulation of the sample.
    Type: Grant
    Filed: September 16, 2008
    Date of Patent: October 1, 2013
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Christopher Power, Helmut Lippert, Benno Radt, Christian Dietrich
  • Patent number: 8482854
    Abstract: The invention is directed to a sample holder for a microscope. The sample holder comprises a sample chamber which is filled with an immersion liquid and in which a sample is located. The sample chamber has an upper opening. It further comprises means for translating the sample relative to a detection objective of the microscope, and means for rotating the sample around an axis of rotation extending in a substantially horizontal plane which encloses an angle other than zero degrees with the optical axis of the detection objective. In a sample holder of this kind, the sample is embedded in a transparent embedding medium having at least partially a greater solidity than the immersion liquid. Further, the sample chamber has means for horizontally supporting the embedded sample against the effect of gravity.
    Type: Grant
    Filed: March 26, 2008
    Date of Patent: July 9, 2013
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Helmut Lippert, Benno Radt, Christopher Power, Christian Dietrich
  • Patent number: 8362448
    Abstract: Apparatus and method for high spatial resolution imaging of a sample's structure, including a diffraction-limited resolution volume with a plurality of dye molecules which can be switched between different states and have a distribution density which is greater than the inverse of the diffraction-limited resolution volume, where at least one state is fluorescing, the fluorescence being collected by an objective lens and imaged on a spatially resolving detector by an optical system. At least one light source provided for emitting a switching radiation and for emitting an excitation radiation. At least one of the light sources is arranged to radiate through the sample, and a switching and/or fluorescence excitation of the dye molecules is carried out. The switching is a photoactivation or a photodeactivation of the dye molecules. A focusing arrangement is provided for switching and/or for excitation to generate a line-like illumination region extending in a direction of illumination.
    Type: Grant
    Filed: February 3, 2009
    Date of Patent: January 29, 2013
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Ralf Wolleschensky, Helmut Lippert, Christopher Power, Benno Radt
  • Patent number: 8350230
    Abstract: A method and an arrangement for analyzing a specimen, wherein the specimen is supported so as to be rotatable around an axis of rotation and displaceable in all three spatial directions and is illuminated by a first illumination device. Light radiated from the specimen is imaged on a detection device. A plurality of sectional images of the specimen are recorded at different settings of the rotational angle, and the specimen is rotated. The recorded sectional images are fused to form a data set of spatial image data of the specimen. The specimen is then illuminated by a second illumination device perpendicular to the axis of rotation, wherein a plurality of shadow images of the specimen are recorded and the specimen is rotated. A second data set of spatial image data of the specimen is constructed from the recorded shadow images by means of a back projection algorithm.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: January 8, 2013
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Christopher Power, Helmut Lippert, Dietrich Christian, Benno Radt
  • Publication number: 20120282667
    Abstract: The invention relates to methods for positioning at least one preferably biological specimen in the specimen space of a microscope arrangement, and to devices for carrying out these methods. Methods and devices arc proposed, wherein the specimen's orientation relative to a detection objective's optical axis can be repeatedly changed and, in doing so, the specimen is held so that a substantially unobstructed view of the specimen is ensured from every detection direction. In different constructional variants, the specimen is held at a supporting device by adhesive forces or by a flowing medium, the specimen is held at a capillary opening by capillary action, or at least one specimen is embedded in a body of transparent gel, and the gel body is fixed in the specimen space by means of a rotatable holding device, and the detection direction is changed by rotating the holding device by a given angle of rotation.
    Type: Application
    Filed: July 20, 2012
    Publication date: November 8, 2012
    Inventors: Helmut Lippert, Benno Radt, Christian Dietrich, Christopher Power
  • Patent number: 8228499
    Abstract: The invention relates to methods for positioning at least one preferably biological specimen in the specimen space of a microscope arrangement, and to devices for carrying out these methods. Methods and devices are proposed, wherein the specimen's orientation relative to a detection objective's optical axis can be repeatedly changed and, in doing so, the specimen is held so that a substantially unobstructed view of the specimen is ensured from every detection direction. In different constructional variants, the specimen is held at a supporting device by adhesive forces or by a flowing medium, the specimen is held at a capillary opening by capillary action, or at least one specimen is embedded in a body of transparent gel, and the gel body is fixed in the specimen space by means of a rotatable holding device, and the detection direction is changed by rotating the holding device by a given angle of rotation.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: July 24, 2012
    Assignee: Carl Zeiss MicroImaging GmbH
    Inventors: Helmut Lippert, Benno Radt, Christian Dietrich, Christopher Power
  • Patent number: 8213081
    Abstract: The invention relates to an objective replacement device for a microscope, wherein the sample is located in a sample chamber and surrounded by an immersion medium within the sample chamber, means for positioning and aligning the sample relative to the focus of an objective being present, wherein the detection beam path is aligned horizontally, which is to say perpendicular to the direction of action of gravity. For an objective replacement device for a microscope of the type described above, according to the invention a device is provided for exchanging the objective, at the focus of which the sample is positioned and aligned, with at least another objective, the position and alignment of the sample within the sample chamber remaining the same.
    Type: Grant
    Filed: April 4, 2008
    Date of Patent: July 3, 2012
    Assignee: Carl Zeiss MicroImaging GmbH
    Inventors: Helmut Lippert, Benno Radt, Christian Dietrich, Christopher Power
  • Publication number: 20110170182
    Abstract: An arrangement for holding and positioning a sample in the detection area of the objective of a microscope, the detection area being located in a chamber which is filled with an immersion liquid. This arrangement includes (1) a sample holder to which the sample is affixed so as to lie upon a point P in a coordinate system X, Y, Z, coordinate Z being defined by the optical axis of the microscope objective and the coordinate origin laying within the detection area, (2) a device by which the position of point P can be varied within the coordinate system X, Y, Z, wherein the range of variation comprehends the detection area, and (3) a device for rotating the sample affixed to the sample holder around point P, wherein a straight line G which encloses with coordinate Z an angle ? whose size can be changed is the axis of rotation.
    Type: Application
    Filed: July 28, 2009
    Publication date: July 14, 2011
    Inventors: Helmut Lippert, Christopher Power, Christian Dietrich, Benno Radt
  • Publication number: 20110094318
    Abstract: The invention is directed to method for positioning and aligning a preferably biological sample in the detection area of the objective of a microscope arrangement. According to the invention, the method mentioned above has the following method steps: a sample is introduced into a transparent medium, preferably agarose gel, which is initially liquid; the medium is changed from the liquid state to the solid state, wherein the sample is fixated within the medium, but the transparency of the medium is retained; the solidified medium is positioned in the microscope arrangement in such a way that the sample enclosed therein is situated in the detection area of the objective. Further, a device is proposed for positioning and aligning a preferably biological sample in the detection area of the objective of a microscope arrangement.
    Type: Application
    Filed: June 6, 2009
    Publication date: April 28, 2011
    Inventors: Wibke Hellmich, Benno Radt, Helmut Lippert, Olaf Selchow, J├╝rgen Haese, Uwe Wolf
  • Publication number: 20110036996
    Abstract: Apparatus and method for high spatial resolution imaging of a sample's structure, including a diffraction-limited resolution volume with a plurality of dye molecules which can be switched between different states and have a distribution density which is greater than the inverse of the diffraction-limited resolution volume, where at least one state is fluorescing, the fluorescence being collected by an objective lens and imaged on a spatially resolving detector by an optical system. At least one light source provided for emitting a switching radiation and for emitting an excitation radiation. At least one of the light sources is arranged to radiate through the sample, and a switching and/or fluorescence excitation of the dye molecules is carried out. The switching is a photoactivation or a photodeactivation of the dye molecules. A focusing arrangement is provided for switching and/or for excitation to generate a line-like illumination region extending in a direction of illumination.
    Type: Application
    Filed: February 3, 2009
    Publication date: February 17, 2011
    Inventors: Ralf Wolleschensky, Helmut Lippert, Christopher Power, Benno Radt
  • Patent number: RE45575
    Abstract: The invention is directed to an optical arrangement with a light source for emitting a light bundle and with optical elements for transforming this light bundle into the shape of a light sheet, particularly suitable for illuminating individual planes of a three-dimensional specimen in selective plane illumination microscopy (SPIM). According to the invention, means are provided for varying the cross section of the light sheet, for varying the length of the light sheet and/or for influencing the direction in which individual beam components extending within the light sheet are directed to the specimen substance. This makes it possible to adapt the geometry of the light sheet to the illumination requirements for observing one and the same specimen plane with a plurality of different objectives and, if required, to reduce shadows occurring within the observed specimen plane as a result of the illumination.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: June 23, 2015
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Helmut Lippert, Matthias Wald, Benno Radt
  • Patent number: D777118
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: January 24, 2017
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Alexander Gaiduk, Wolf Jockusch, Dominik Stehr, Robert Schrem, Peter Weber, Benno Radt