Patents by Inventor Benoît Antoine SCHMITT

Benoît Antoine SCHMITT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10508111
    Abstract: The present invention discloses compounds according to Formula I: wherein R1, R2, and Cy are as defined herein. The present invention relates to compounds inhibiting IRAK family kinases, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, autoimmune diseases and/or proliferative diseases by administering the compound of the invention.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: December 17, 2019
    Assignee: GALAPAGOS NV
    Inventors: Reginald Christophe Xavier Brys, Raphaël Jean Joël Geney, Agnès Marie Joncour, Julien Georges Pierre-Olivier Doyon, Frédéric Gilbert Labéguère, Jean-Michel Lefrançois, Oscar Mammoliti, Benoît Antoine Schmitt, Steven Emiel Van Der Plas, Christel Jeanne Marie Menet
  • Publication number: 20180305351
    Abstract: The present invention discloses compounds according to Formula I: wherein R1, R2, and Cy are as defined herein. The present invention relates to compounds inhibiting IRAK family kinases, methods for their production, pharmaceutical compositions comprising the same, and methods of treatment using the same, for the prophylaxis and/or treatment of inflammatory diseases, autoimmune diseases and/or proliferative diseases by administering the compound of the invention.
    Type: Application
    Filed: October 14, 2016
    Publication date: October 25, 2018
    Inventors: Reginald Christophe Xavier BRYS, Raphaël Jean Joël GENEY, Agnès Marie JONCOUR, Julien Georges Pierre-Olivier DOYON, Frédéric Gilbert LABÉGUÈRE, Jean-Michel LEFRANÇOIS, Oscar MAMMOLITI, Benoît Antoine SCHMITT, Steven Emiel VAN DER PLAS, Christel Jeanne Marie MENET
  • Patent number: 9062051
    Abstract: The present invention discloses compounds according to Formula I: wherein R1, R2, R3, R4, L, and X are as defined herein. The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and their use in the prophylaxis and/or treatment of inflammatory conditions, type 2 diabetes, neurological and/or neurodegenerative diseases, autoimmune diseases, proliferative diseases (in particular metastatic diseases, and/or cancer), abnormal angiogenesis associated diseases, degradation of cartilage, and/or disruption of cartilage homeostasis, in particular in the prophylaxis and/or treatment of cancer. The present invention also discloses methods of treatment using the same compounds, for the prophylaxis and/or treatment of said diseases by administering the compound of the invention.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: June 23, 2015
    Assignee: GALAPAGOS NV
    Inventors: Laurent Raymond Maurice Sanière, Jacques Huck, Graeme James Dykes, Benoit Antoine Schmitt, Javier Blanc, Anna Sara Butler, Florence Marie-Emilie Bonnaterre, Stéphane Nicolas Alain Beaumont
  • Publication number: 20150080391
    Abstract: The present invention discloses compounds according to Formula I: wherein R1, R2, R3, R4, L, and X are as defined herein. The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and their use in the prophylaxis and/or treatment of inflammatory conditions, type 2 diabetes, neurological and/or neurodegenerative diseases, autoimmune diseases, proliferative diseases (in particular metastatic diseases, and/or cancer), abnormal angiogenesis associated diseases, degradation of cartilage, and/or disruption of cartilage homeostasis, in particular in the prophylaxis and/or treatment of cancer. The present invention also discloses methods of treatment using the same compounds, for the prophylaxis and/or treatment of said diseases by administering the compound of the invention.
    Type: Application
    Filed: August 18, 2014
    Publication date: March 19, 2015
    Inventors: Laurent Raymond Maurice SANIÈRE, Jacques HUCK, Graeme James DYKES, Benoit Antoine SCHMITT, Javier BLANC, Anna Sara BUTLER, Florence Marie-Emilie BONNATERRE, Stéphane Nicolas Alain BEAUMONT
  • Publication number: 20130217664
    Abstract: Novel imidazolopyridines according to Formula I, able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons. Wherein R1, L1, R3, R4, Cy, L2 and R5 are as defined herein.
    Type: Application
    Filed: February 7, 2013
    Publication date: August 22, 2013
    Inventors: Christel Jeanne Marie MENET, Benoit Antoine SCHMITT, Raphael Jean Joel GENEY, Kevin James DOYLE, Joanne PEACH, Nicholas John PALMER, Graham Peter JONES, David HARDY, James Edward Stewart DUFFY
  • Patent number: 8318736
    Abstract: HIV replication inhibitors of formula wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and X have specific definitions, and pharmaceutical compositions containing these compounds as active ingredient and processes for preparing said compounds and compositions.
    Type: Grant
    Filed: December 28, 2007
    Date of Patent: November 27, 2012
    Assignee: Janssen R&D Ireland
    Inventors: Jerôme Emile Georges Guillemont, Céline Isabelle Mordant, Benoit Antoine Schmitt
  • Patent number: 8163745
    Abstract: This invention concerns 5-(hydroxymethylene and aminomethylene)pyrimidine derivatives having HIV (Human Immunodeficiency Virus) replication inhibiting properties, to the preparation thereof and to pharmaceutical compositions comprising these compounds.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: April 24, 2012
    Assignee: Tibotec Pharmaceuticals Ltd.
    Inventors: Jerôme Emile Georges Guillemont, Céline Isabelle Mordant, Benoit Antoine Schmitt
  • Publication number: 20100261722
    Abstract: HIV replication inhibitors of formula R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyl; C1-6alkyloxycarbonyl; R2, R3, R7 and R8 are hydrogen; hydroxy; halo; C3-7cycloalkyl; C1-6alkyloxy; carboxyl; C1-6alkyloxycarbonyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-6alkyl; polyhaloC1-6alkyloxy; —C(?O)R10; C1-6alkyl optionally substituted with halo, cyano or —C(?O)R10; optionally substituted C1-6alkyl, C2-6alkenyl, or C2-6alkynyl; R4 and R9 are hydroxy; halo; C3-7cycloalkyl; C1-6alkyloxy; carboxyl; C1-6alkyloxycarbonyl; formyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-6alkyl; polyhaloC1-6alkyloxy; —C(?O)R10; cyano; —S(?O)rR10; —NH—S(?O)2R10; —NHC(?O)H; —C(?O)NHNH2; —NHC(?O)R10; Het; —Y-Het; optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl; R5 is C2-6alkenyl or C2-6alkynyl both substituted with cyano, aminocarbonyl, mono- and di(C1-6alkyl)aminocarbonyl, aryl, pyridyl, thienyl, furanyl, or with one or two C1-6alkyloxy groups; Het; —C(?O)NR5aR5b; —C
    Type: Application
    Filed: December 28, 2007
    Publication date: October 14, 2010
    Inventors: Jerôme Emile Georges Guillemont, Céline Isabelle Mordant, Benoit Antoine Schmitt
  • Publication number: 20100234375
    Abstract: This invention concerns 5-(hydroxymethylene and aminomethylene)pyrimidine derivatives having HIV (Human Immunodeficiency Virus) replication inhibiting properties, to the preparation thereof and to pharmaceutical compositions comprising these compounds.
    Type: Application
    Filed: March 30, 2007
    Publication date: September 16, 2010
    Applicant: TIBOTEC PHARMACEUTICALS LTD.
    Inventors: Jerôme Emile Georges Guillemont, Céline Isabelle Mordant, Benoit Antoine Schmitt
  • Publication number: 20080242661
    Abstract: The present invention relates to compounds that are inhibitors of PDE1A, a phosphodiesterase that is involved in the modulation of the degradation of cartilage, joint degeneration and diseases involving such degradation and/or inflammation.
    Type: Application
    Filed: December 10, 2007
    Publication date: October 2, 2008
    Inventors: Graeme James Dykes, Stephen Robert Fletcher, Christel Jeanne Marie Menet, Nuria Merayo Merayo, Benoit Antoine Schmitt