Patents by Inventor Benoit de Crombrugghe

Benoit de Crombrugghe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Master bone formation transcription factor: compositions and methods of use
    Patent number: 7160722
    Abstract: A novel gene expressed selectively by osteoblast lines is provided. Expression of the gene is highly restricted to cells of osteoblast lineage, including precursor cells. Also provided is a method for promoting bone formation by providing agents that bind to the novel gene within osteoblast cells to stimulate bone formation.
    Type: Grant
    Filed: November 30, 2000
    Date of Patent: January 9, 2007
    Assignee: Board of Regents, The University of Texas System
    Inventors: Benoit de Crombrugghe, Kazuhisa Nakashima, Xin Zhou
  • Ha4,a new osteoblast-and chondrocyte-specific small secreted peptide, compositions and methods of use
    Publication number: 20060253914
    Abstract: A polypeptide designated HA4, expressed selectively by bone tissue, is provided. Transgenic animals that fail to express HA4 have bone formation abnormalities reflective of osteoporosis, Also provided are methods for promoting bone formation by increasing the activity or expression of HA4, methods of diagnosing or treating bone degenerative diseases, and methods of screening for drugs that alter bone formation.
    Type: Application
    Filed: November 4, 2003
    Publication date: November 9, 2006
    Inventors: Benoit De Crombrugghe, Haruhiko Akiyama
  • Master bone formation transcription factor: compositions and methods of use
    Publication number: 20020156031
    Abstract: A novel gene expressed selectively by osteoblast lines is provided. Expression of the gene is highly restricted to cells of osteoblast lineage, including precursor cells. Also provided is a method for promoting bone formation by providing agents that bind to the novel gene within osteoblast cells to stimulate bone formation.
    Type: Application
    Filed: November 30, 2000
    Publication date: October 24, 2002
    Applicant: Board of Regents, The University of Texas System
    Inventors: Benoit de Crombrugghe, Kazuhisa Nakashima, Xin Zhou