Patents by Inventor Benoit Deprez

Benoit Deprez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ERAP INHIBITORS
    Publication number: 20240101542
    Abstract: The present disclosure relates to novel compounds of formula (I) which are useful as inhibitors of endoplasmic reticulum aminopeptidases (ERAP), in particular as inhibitors of ERAP2. The disclosure also relates to the therapeutic use of these compounds, in particular the use of these compounds in the treatment or prophylaxis of proliferative disorders, autoinflammatory disorders and autoimmune disorders.
    Type: Application
    Filed: December 17, 2021
    Publication date: March 28, 2024
    Inventors: Rebecca DEPREZ POULAIN, Ronan GEALAGEAS, Virgyl CAMBERLEIN, Charlotte TABEY FLEAU, Valentin GUILLAUME, Damien BOSC, Benoit DEPREZ, Pierre SIEROCKI
  • COMPOUND AND METHOD FOR THE TREATMENT OF CORONAVIRUSES
    Publication number: 20230233483
    Abstract: The disclosure relates to the use of clofoctol in the prevention or treatment of a disease caused by a coronavirus, in particular Covid-19.
    Type: Application
    Filed: June 8, 2021
    Publication date: July 27, 2023
    Applicants: Apteeus, Universite De Lille, Centre National De La Recherche Scientifique, Institut National De La Sante Et De La Recherche Medicale, Centre Hospitalier Universitaire De Lille
    Inventors: Terence Beghyn, Benoît Deprez, Sandrine Belouzard, Priscille Brodin
  • 5-MEMBERED HETEROARYL COMPOUNDS CONTAINING A HYDROXAMATE MOIETY AND THEIR USE
    Publication number: 20220073475
    Abstract: The present invention is directed to 5-membered heteroaryl compounds containing a hydroxamate moiety of Formula I, pharmaceutically acceptable salts or solvates thereof, and their use as sensitizers for chemotherapy of malignant tumors.
    Type: Application
    Filed: January 16, 2020
    Publication date: March 10, 2022
    Inventors: Rebecca DEPREZ POULAIN, Benoit DEPREZ, Florence LEROUX, Damien BOSC, Ronan GEALAGEAS, Jouda JAKHLAL, Peter VAN ENDERT, Nathalie HENNUYER, Bart STAELS
  • Compounds
    Patent number: 11254689
    Abstract: The invention relates to compounds of Formula (I) and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacterium, such as tuberculosis.
    Type: Grant
    Filed: August 15, 2018
    Date of Patent: February 22, 2022
    Assignees: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED, BIOVERSYS AG
    Inventors: Esther Porras De Francisco, Modesto Jesús Remuiñan-Blanco, Marilyne Bourotte, Benoit Deprez, Nicolas Willand
  • Compounds
    Patent number: 11253499
    Abstract: The invention relates to compounds of Formula (I) and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by Mycobacterium, such as tuberculosis.
    Type: Grant
    Filed: August 15, 2018
    Date of Patent: February 22, 2022
    Assignees: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED, BIOVERSYS AG
    Inventors: Esther Porras De Francisco, Modesto Jesús Remuiñan-Blanco, Marilyne Bourotte, Benoit Deprez, Geoffroy Dequirez, Nicolas Willand
  • NOVEL COMPOUNDS
    Publication number: 20210032268
    Abstract: The invention relates to compounds of Formula (I) and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacterium, such as tuberculosis.
    Type: Application
    Filed: August 15, 2018
    Publication date: February 4, 2021
    Applicants: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED, BIOVERSYS AG
    Inventors: Esther PORRAS DE FRANCISCO, Modesto Jesús REMUIÑAN-BLANCO, Marilyne BOUROTTE, Benoit DEPREZ, Nicolas WILLAND
  • NOVEL COMPOUNDS
    Publication number: 20200253967
    Abstract: The invention relates to compounds of Formula (I) and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacterium, such as tuberculosis.
    Type: Application
    Filed: August 15, 2018
    Publication date: August 13, 2020
    Inventors: Esther PORRAS DE FRANCISCO, Modesto Jesús REMUIÑAN-BLANCO, Marilyne BOUROTTE, Benoit DEPREZ, Nicolas WILLAND
  • NOVEL COMPOUNDS
    Publication number: 20200170997
    Abstract: The invention relates to compounds of Formula (I) and their use in therapy, for example in the treatment of mycobacterial infections or in the treatment of diseases caused by mycobacterium, such as tuberculosis.
    Type: Application
    Filed: August 15, 2018
    Publication date: June 4, 2020
    Inventors: Esther PORRAS DE FRANCISCO, Modesto Jesús REMUIÑAN-BLANCO, Marilyne BOUROTTE, Benoit DEPREZ, Geoffroy DEQUIREZ, Nicolas WILLAND
  • Imidazol- or 1,2,4-triazol-derivatives and their use
    Patent number: 10323016
    Abstract: The present invention is directed to novel compounds of formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: June 18, 2019
    Assignees: UNIVERSITE DE LILLE 2 DROIT ET SANTE, INSTITUT PASTEUR DE LILLE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Julie Charton, Benoit Deprez, Florence Leroux, Bart Staels, Anne Muhr-Tailleux, Nathalie Hennuyer, Sophie Lestavel, Manuel Lassalle, Barbara Dubanchet
  • Compound useful for the treatment of nonsense-mutation-mediated diseases and pharmaceutical composition comprising said compound
    Patent number: 10265302
    Abstract: The present invention relates to the compound of formula (I) for use in the treatment of a nonsense-mutation-mediated genetic disease.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: April 23, 2019
    Assignees: UNIVERSITE DE LILLE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT PASTEUR DE LILLE
    Inventors: Fabrice Lejeune, Benoit Deprez, Terence Beghyn, Sara Sofia Gonzalez-Hilarion
  • Spiroisoxazoline compounds having an activity potentiating the activity of an antibiotic
    Patent number: 10174050
    Abstract: The present invention concerns a spiroisoxazoline compound of general formula (I): in which m and n are 0 or 1, R1 represents, inter alia, an optionally substituted alkyl chain, in particular substituted with fluorine or with a cyclic group, and R2 is chosen from phenyl and optionally substituted benzyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and the heterocycles having 5 or 6 vertices comprising at least one atom chosen from S, N and O. The present invention also concerns the use of this compound as a drug, in particular in the treatment of bacterial and mycobacterial infections such as tuberculosis in combination with an antibiotic that is active against bacteria and/or mycobacteria, said compound potentiating the activity of said antibiotic.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: January 8, 2019
    Assignee: Universite de Droit et de la Sante de Lille 2
    Inventors: Nicolas Willand, Benoit Deprez, Alain Baulard, Priscille Brodin, Matthieu Frederik Desroses, Laurence Agouridas-Dutot
  • COMPOUND USEFUL FOR THE TREATMENT OF NONSENSE-MUTATION-MEDIATED DISEASES AND PHARMACEUTICAL COMPOSITION COMPRISING SAID COMPOUND
    Publication number: 20180147191
    Abstract: The present invention relates to the compound of formula (I) for use in the treatment of a nonsense-mutation-mediated genetic disease.
    Type: Application
    Filed: January 29, 2018
    Publication date: May 31, 2018
    Inventors: Fabrice LEJEUNE, Benoit DEPREZ, Terence BEGHYN, Sara Sofia GONZALEZ-HILARION
  • Saturated nitrogen and N-acylated heterocycles potentiating the activity of an active antibiotic against
    Patent number: 9957249
    Abstract: The present invention concerns a compound of general formula (I): in which n=0 or 1, R1 represents an optionally substituted alkyl chain, in particular substituted alkyl chain, in particular substituted with fluorine, X is chosen from N and CH, and R2 is chosen from optionally substituted phenyl and benzyl, wherein the heterocycles having 6 vertices comprise one, two or three nitrogen atoms. The present invention also concerns the use of this compound as a medicament, in particular in the treatment of bacterial and mycobacterial infections such as tuberculosis in combination with an antibiotic that is active against bacteria and/or mycobacteria, said compound potentiating the activity of said antibiotic.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: May 1, 2018
    Assignee: UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2
    Inventors: Nicolas Willand, Benoit Deprez, Alain Baulard, Priscille Brodin, Marion Flipo, Lucie Maingot
  • 2-oxo-3,4-dihydropyridine-5-carboxylates and their use
    Patent number: 9932309
    Abstract: The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.
    Type: Grant
    Filed: July 28, 2015
    Date of Patent: April 3, 2018
    Assignees: Universite de Lille 2 Droit et Sante, Institut Pasteur de Lille, INSERM
    Inventors: Julie Charton, Benoit Deprez, Florence Leroux, Bart Staels, Anne Muhr-Tailleux, Nathalie Hennuyer, Sophie Lestavel, Sylvain Picon, Karen Aknin, Rajaa Boulahjar, Barbara Dubanchet
  • Compounds for use in the treatment of mycobacterial infections
    Patent number: 9920042
    Abstract: The present invention concerns compounds of general formula (I): in which Y and Z are chosen from CH and N; T is chosen from CO or SO2; n is 1 to 3; R1 represents a group chosen, for example, from C1-C3 alkyl chains unsubstituted or substituted by fluorine, the unsubstituted or substituted cyclic, cyano, azido, alkoxy and phenyl groups; and R is chosen from the azido, cyano, alkinyl and 2-benzothiazolyl groups and an optionally substituted aromatic heterocycle with five vertices; and the use thereof in the treatment of bacterial and mycobacterial infections such as, for example, tuberculosis, leprosy and atypical mycobacterial infections. The present invention also concerns pharmaceutical compositions comprising, as the active ingredient, at least one of the abovementioned compounds and optionally an antibiotic activatable via the EthA pathway.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: March 20, 2018
    Assignee: UNIVERSITE DE DROIT ET DE LA SANTE DE LILLE 2
    Inventors: Nicolas Willand, Benoit Deprez, Alain Baulard, Priscille Brodin, Olivier Sperando, Vincent Villeret, Baptiste Villemagne
  • Compound useful for the treatment of nonsense-mutation-mediated diseases and pharmaceutical composition comprising said compound
    Patent number: 9913829
    Abstract: The present invention relates to the compound of formula (I) for use in the treatment of a nonsense-mutation-mediated genetic disease.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: March 13, 2018
    Assignees: UNIVERSITE DE DROIT ET DE SANTE DE LILLE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), INSTITUT PASTEUR DE LILLE
    Inventors: Fabrice Lejeune, Benoit Deprez, Terence Beghyn, Sara Sofia Gonzalez-Hilarion
  • 2-OXO-3,4-DIHYDROPYRIDINE-5-CARBOXYLATES AND THEIR USE
    Publication number: 20170210710
    Abstract: The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.
    Type: Application
    Filed: July 28, 2015
    Publication date: July 27, 2017
    Inventors: Julie Charton, Benoit Deprez, Florence Leroux, Bart Staels, Anne Muhr-Tailleux, Nathalie Hennuyer, Sophie Lestavel, Sylvain Picon, Karen Aknin, Rajaa Boulahjar, Barbara Dubanchet
  • IMIDAZOL- OR 1,2,4-TRIAZOL-DERIVATIVES AND THEIR USE
    Publication number: 20170190687
    Abstract: The present invention is directed to novel compounds of formula (I), pharmaceutically acceptable salts or solvates thereof, and their use.
    Type: Application
    Filed: June 11, 2015
    Publication date: July 6, 2017
    Inventors: Julie Charton, Benoit Deprez, Florence Leroux, Bart Staels, Anne Muhr-Tailleux, Nathalie Hennuyer, Sophie Lestavel, Manuel Lassalle, Barbara Dubanchet
  • PIPERAZINYL DERIVATIVES FOR THE TREATMENT OF CANCER
    Publication number: 20160237042
    Abstract: Piperazinyl derivatives of formula (I) and their use as a drug, particularly for the treatment of cancer, are disclosed. Also disclosed are pharmaceutical compositions comprising the piperazinyl derivatives, and methods for synthesizing the piperazinyl derivatives.
    Type: Application
    Filed: April 22, 2016
    Publication date: August 18, 2016
    Inventors: Denis CARNIATO, Jean-Francois BRIAND, Mathieu GUTMANN, Olivier BUSNEL, Cécile BOUGERET, Benoit DEPREZ, Karine JAILLARDON
  • Spiroisoxazoline Compounds Having an Activity Potentiating the Activity of an Antibiotic
    Publication number: 20150344498
    Abstract: The present invention concerns a spiroisoxazoline compound of general formula (I): in which m and n are 0 or 1, R1 represents, inter alia, an optionally substituted alkyl chain, in particular substituted with fluorine or with a cyclic group, and R2 is chosen from phenyl and optionally substituted benzyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and the heterocycles having 5 or 6 vertices comprising at least one atom chosen from S, N and O. The present invention also concerns the use of this compound as a drug, in particular in the treatment of bacterial and mycobacterial infections such as tuberculosis in combination with an antibiotic that is active against bacteria and/or mycobacteria, said compound potentiating the activity of said antibiotic.
    Type: Application
    Filed: December 20, 2013
    Publication date: December 3, 2015
    Applicant: Universite de Droit et de la Sante de Lille 2
    Inventors: Nicolas Willand, Benoit Deprez, Alain Baulard, Priscille Brodin, Matthieu Frederik Desroses, Laurence Agouridas-Dutot