Patents by Inventor Benoit Hornsperger

Benoit Hornsperger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC COMPOUNDS
    Publication number: 20230203056
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein X, Y, Z, A, L, B, and R1 to R3 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: February 22, 2023
    Publication date: June 29, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Rainer E. MARTIN, Fionn O'HARA, Hans RICHTER, Martin RITTER, Philipp SCHMID
  • BEZOXAZINE DERIVATIVES USEFUL AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20230183224
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1, R2 and R3 are as described herein, pharmaceutically acceptable salts thereof, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: November 22, 2022
    Publication date: June 15, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Charles BELL, Joerg BENZ, Uwe GRETHER, Benoit HORNSPERGER, Buelent KOCER, Bernd KUHN, Hans RICHTER, Satoshi TSUCHIYA
  • OXAZINE MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS
    Publication number: 20230117324
    Abstract: The invention provides new heterocyclic compounds having the general formula (Ic) wherein A, L, X, m, n and R20 to R23 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: August 9, 2022
    Publication date: April 20, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Charles BELL, Joerg BENZ, Luca GOBBI, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Dennis Jul HANSEN, Benoit HORNSPERGER, Buelent KOCER, Carsten KROLL, Bernd KUHN, Fionn O'HARA, Hans RICHTER, Martin RITTER, Satoshi TSUCHIYA, Rui CHEN
  • Octahydropyrido[1,2-alpha]pyrazines as MAGL inhibitors
    Patent number: 11608347
    Abstract: The invention provides new heterocyclic compounds having the general formula (Ie) wherein R1, R1a and R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Grant
    Filed: July 7, 2020
    Date of Patent: March 21, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Ann Petersen, Joerg Benz, Uwe Grether, Benoit Hornsperger, Buelent Kocer, Bernd Kuhn, Hans Richter, Satoshi Tsuchiya, Yangcheng Qiu, Rui Chen
  • HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20230050901
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: May 20, 2022
    Publication date: February 16, 2023
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Charles BELL, Joerg BENZ, Luca GOBBI, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Benoit HORNSPERGER, Buelent KOCER, Carsten KROLL, Bernd KUHN, Marius Daniel Rinaldo LUTZ, Fionn O'HARA, Hans RICHTER, Martin RITTER, Didier ROMBACH, Martin KURATLI
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20220275005
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L, X, R1, R2, R3 and R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: May 5, 2022
    Publication date: September 1, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Marius Daniel Rinaldo LUTZ, Fionn O`HARA, Hans RICHTER
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20220267349
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, Q, U, V, W, X, Z, m, n, and R1 to R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: January 31, 2022
    Publication date: August 25, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Luca GOBBI, Uwe GRETHER, Steven Paul HANLON, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Martin KURATLI, Guofu LIU, Fionn O`HARA, Hans RICHTER, Martin RITTER
  • Heterocyclic compounds
    Patent number: 11420961
    Abstract: The invention provides new heterocyclic compounds having the general formula (IA) wherein A, L, X, Y, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: August 23, 2022
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Joerg Benz, Uwe Grether, Benoit Hornsperger, Buelent Kocer, Bernd Kuhn, Hans Richter, Satoshi Tsuchiya, Charles Bell, Xiang Wu, Xiaofei Yan, Luca Gobbi
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20220242876
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein R1, R2, X, and Y are as defined herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: January 6, 2022
    Publication date: August 4, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Carsten KROLL, Flore REGGIANI, Miroslav KOSAR, Maurice BIEDERMANN, Bernd KUHN, Benoit HORNSPERGER, Uwe GRETHER, Fionn O'HARA, Hans RICHTER
  • Piperazine derivatives as MAGL inhibitors
    Patent number: 11390610
    Abstract: The invention provides new heterocyclic compounds having the general Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, X, Y1 and Y2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: July 19, 2022
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Joerg Benz, Uwe Grether, Benoit Hornsperger, Bernd Kuhn, Hans Richter, Buelent Kocer, Fionn O'Hara, Martin Ritter, Satoshi Tsuchiya, Ludovic Collin, Simon E. Johnson, Charles Bell
  • FLUORESCENT PROBES FOR MONOACYLGLYCEROL LIPASE (MAGL)
    Publication number: 20220220373
    Abstract: The invention provides fluorescent probes having the general formula (I) wherein X, Y, L and R1 to R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: March 22, 2022
    Publication date: July 14, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Thais GAZZI, Luca GOBBI, Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Yelena MOSTINSKI, Marc NAZARE, Fionn O'HARA, Hans RICHTER
  • HETEROCYCLIC MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS
    Publication number: 20220213093
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein R1 to R3 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: December 16, 2021
    Publication date: July 7, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Fionn O'HARA, Hans RICHTER
  • RADIOLABELED COMPOUNDS
    Publication number: 20220202963
    Abstract: The invention provides new radiolabeled monoacylglycerol lipase (MAGL) inhibitors that are useful for medical imaging, such as positron-emission tomography (PET), single-photon emission computed tomography (SPECT) and/or autoradiography.
    Type: Application
    Filed: March 11, 2022
    Publication date: June 30, 2022
    Applicants: Hoffmann-La Roche Inc., ETH ZUERICH
    Inventors: Ludovic COLLIN, Martin EDELMANN, Luca GOBBI, Uwe GRETHER, Thomas HARTUNG, Yingfang HE, Michael HONER, Benoit HORNSPERGER, Carsten KROLL, Linjing MU, Dieter MURI, Fionn O'HARA, Hans RICHTER, Martin RITTER
  • HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MONOACYLGLYCEROL LIPASE (MAGL)
    Publication number: 20220135591
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein R1 to R7, A, L1, and RA1 to RA3 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: October 8, 2021
    Publication date: May 5, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Guillaume DECORET, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Benoit HORNSPERGER, Bernd KUHN, Hans RICHTER, Didier ROMBACH, Fionn O'HARA, Carsten KROLL
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20220106328
    Abstract: The invention provides new heterocyclic compounds having the general formulae (Ia) and (Ib) wherein A, B, and L are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: December 16, 2021
    Publication date: April 7, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Luca GOBBI, Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Rainer E. MARTIN, Fionn O`HARA, Bernd PUELLMANN, Hans RICHTER, Martin RITTER
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20220098176
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein B, C, L, X, Y, RL and R3 to R5 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: September 2, 2021
    Publication date: March 31, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Joerg BENZ, Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Rainer E. MARTIN, Fionn O'HARA, Bernd PUELLMANN, Hans RICHTER, Martin RITTER
  • MODIFIED IL-18 POLYPEPTIDES AND USES THEREOF
    Publication number: 20220056091
    Abstract: The present disclosure relates to modified IL-18 polypeptides, compositions comprising modified IL-18 polypeptides, methods of making the same, and methods of using the modified IL-18 polypeptides for treatment of diseases. In one aspect, the disclosure relates to the treatment of cancer using the modified IL-18 polypeptides. In some embodiments, the disclosed IL-18 polypeptides induce the production of IFN?. In some embodiments, the disclosed IL-18 polypeptides induce the production of IFN? without being neutralized by IL-18 binding protein.
    Type: Application
    Filed: August 19, 2021
    Publication date: February 24, 2022
    Inventors: Vijaya Raghavan PATTABIRAMAN, Jean-Philippe CARRALOT, Bertolt KREFT, Jeffrey William BODE, Régis BOEHRINGER, Matilde ARÉVALO-RUIZ, Camille DELON, Amélie WIEDERKEHR, Claudia FETZ, Anna HAYDN, Alexander FLOHR, Roberto IACONE, Benoit HORNSPERGER, Chongqing WANG
  • HETEROCYCLIC COMPOUNDS
    Publication number: 20210387999
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L, X, R1, R2, R3 and R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
    Type: Application
    Filed: May 20, 2021
    Publication date: December 16, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Bernd KUHN, Uwe GRETHER, Benoit HORNSPERGER, Hans RICHTER, Carsten KROLL, Katrin GROEBKE ZBINDEN, Fionn O'HARA, Didier ROMBACH, Marius Daniel Rinaldo LUTZ
  • HETEROCYCLIC COMPOUNDS AS MONOACYLGLYCEROL LIPASE INHIBITORS
    Publication number: 20210277020
    Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds, methods of using the compounds and methods of determining the monoacylglycerol lipase (MAGL) inhibitory activity of the compounds.
    Type: Application
    Filed: February 11, 2021
    Publication date: September 9, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Lilli ANSELM, Joerg BENZ, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Dominik HEER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Fionn O`HARA, Hans RICHTER
  • Difluoroketamide derivatives as HtrA1 inhibitors
    Patent number: 11059858
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and R23 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: September 4, 2018
    Date of Patent: July 13, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans P. Maerki, Benoit Hornsperger, Peter Mohr, Michael Reutlinger, Roberto Iacone