Patents by Inventor Benoit Ledoussal

Benoit Ledoussal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic compounds and their use in preventing or treating bacterial infections
    Patent number: 10842779
    Abstract: The present invention relates to heterocyclic compounds, their process of preparation, pharmaceutical compositions comprising these compounds and use thereof, optionally in combination with other antibacterial agents and/or beta-lactam compounds, for the prevention or treatment of bacterial infections. The present invention also relates to the use of these compounds as ?-lactamase inhibitors and/or as antibacterial agents.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: November 24, 2020
    Assignee: MUTABILIS
    Inventors: Julie Brias, Sophie Chasset, Francis Chevreuil, Nicolas Lecointe, Benoit Ledoussal, Frédéric Le Strat, Julien Barbion
  • Inhibitors of viral replication, their process of preparation and their therapeutical uses
    Patent number: 9994509
    Abstract: The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: June 12, 2018
    Assignee: HIVIH
    Inventors: Benoit Ledoussal, Frédéric Le Strat, Sophie Chasset, Julien Barbion, Julie Brias, Audrey Caravano, Fabien Faivre, Sophie Vomscheid
  • Inhibitors of viral replication, their process of preparation and their therapeutical uses
    Patent number: 9604900
    Abstract: The present invention relates to aromatic carbocycle or heterocycle compounds comprising an acid function and being of formula (5), wherein W, Q1, Q2, Q3, Q4, R1, R3, R4, R7, R9, R11, a, c, e, and g are as described in the description; and the use of such compounds in the treatment or the prevention of viral disorders, including HIV.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: March 28, 2017
    Assignee: LABORATOIRE BIODIM
    Inventors: Sophie Chasset, Francis Chevreuil, Benoit Ledoussal, Frédéric Le Strat, Richard Benarous
  • Inhibitors of viral replication, their process of preparation and their therapeutical uses
    Patent number: 9562033
    Abstract: The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: February 7, 2017
    Assignee: LABORATOIRE BIODIM
    Inventors: Richard Benarous, Francis Chevreuil, Benoit Ledoussal, Sophie Chasset, Frédéric Le Strat
  • Inhibitors of viral replication, their process of preparation and their therapeutical uses
    Patent number: 9475802
    Abstract: Inhibitors of viral replication of formula (I), their process of preparation and their therapeutical uses. The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: October 25, 2016
    Assignee: LABORATOIRE BIODIM
    Inventors: Richard Benarous, Francis Chevreuil, Benoit Ledoussal, Sophie Chasset, Frédéric Le Strat
  • Inhibitors of viral replication, their process of preparation and their therapeutical uses
    Publication number: 20160152543
    Abstract: The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Application
    Filed: July 7, 2014
    Publication date: June 2, 2016
    Applicant: LABORATOIRE BIODIM
    Inventors: Benoit LEDOUSSAL, Frédéric LE STRAT, Sophie CHASSET, Julien BARBION, Julie BRIAS, Audrey CARAVANO, Fabien FAIVRE, Sophie VOMSCHEID
  • Inhibitors of viral replication, their process of preparation and their therapeutical uses
    Patent number: 9260395
    Abstract: The present invention relates to compounds of formula (I), their the treatment or the prevention of viral disorders, including HIV.
    Type: Grant
    Filed: October 7, 2013
    Date of Patent: February 16, 2016
    Assignee: LABORATOIRE BIODIM
    Inventors: Richard Benarous, Francis Chevreuil, Benoit Ledoussal, Sophie Chasset, Frédéric Le Strat
  • Inhibitors of Viral Replication, Their Process of Preparation and Their Therapeutical Uses
    Publication number: 20160039783
    Abstract: The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Application
    Filed: October 7, 2013
    Publication date: February 11, 2016
    Inventors: Richard BENAROUS, Francis CHEVREUIL, Benoit LEDOUSSAL, Sophie CHASSET, Frédéric LE STRAT
  • Inhibitors of viral replication, their process of preparation and their therapeutical uses
    Patent number: 9238026
    Abstract: The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: January 19, 2016
    Assignee: LABORATOIRE BIODIM
    Inventors: Sophie Chasset, Francis Chevreuil, Benoit Ledoussal, Frédéric Le Strat, Richard Benarous
  • Inhibitors of Viral Replication, Their Process of Preparation and Their Therapeutical Uses
    Publication number: 20150274673
    Abstract: The present invention relates to compounds of formula (I), their the treatment or the prevention of viral disorders, including HIV.
    Type: Application
    Filed: October 7, 2013
    Publication date: October 1, 2015
    Inventors: Richard Benarous, Francis Chevreuil, Benoit Ledoussal, Sophie Chasset, Frédéric Le Strat
  • Inhibitors of Viral Replication, Their Process of Preparation and Their Therapeutical Uses
    Publication number: 20150274718
    Abstract: Inhibitors of viral replication of formula (I), their process of preparation and their therapeutical uses. The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Application
    Filed: October 11, 2013
    Publication date: October 1, 2015
    Applicant: LABORATOIRE BIODIM
    Inventors: Richard Benarous, Francis Chevreuil, Benoit Ledoussal, Sophie Chasset, Frédéric Le Strat
  • INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES
    Publication number: 20140128383
    Abstract: The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Application
    Filed: April 6, 2012
    Publication date: May 8, 2014
    Applicant: LABORATOIRE BIODIM
    Inventors: Sophie Chasset, Francis Chevreuil, Benoit Ledoussal, Frédéric Le Strat, Richard Benarous
  • INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES
    Publication number: 20140031338
    Abstract: The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.
    Type: Application
    Filed: April 13, 2012
    Publication date: January 30, 2014
    Applicant: LABORATOIRE BIODIM
    Inventors: Sophie Chasset, Francis Chevreuil, Benoit Ledoussal, Frédéric Le Strat, Richard Benarous
  • Substituted pyrazolo[3,4-E][diazepin-6-5(H)ones and analogues thereof, their preparation and their use as antibacterial medicaments
    Patent number: 8148366
    Abstract: The invention relates to nitrogenous heterocyclic compounds of formula (I): in which: R1 represents hydrogen, —(CH2)m—NH2, —(CH2)m—NH(C1-C6)alk, —(CH2)m—N(C1-C6)alk2, —(CH2)m—NH—C(NH)NH2 or —(CH2)m—NH—CH?NH, m is equal to 1 or 2; R2 and R3 together form a nitrogenous heterocycle of aromatic character with 5 vertices containing 1, 2 or 3 nitrogen atoms, substituted on a nitrogen atom by R4; R4 represents hydrogen, C1-C6)alk or a chain of formula: -(A)n-(NH)o—(CH2)p—(CHR?)qR? A represents C?O, C?NH or SO2; R? represents hydrogen or carboxy.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: April 3, 2012
    Assignee: Novexel SA
    Inventors: Benoit Ledoussal, Marie-Edith Gourdel, Emilie Renaud, Camille Pierres, Adel Kebsi
  • Nitrogen-containing heterocyclic compounds, their preparation and their use as antibacterial drugs
    Patent number: 8067435
    Abstract: The invention relates to nitrogen-containing heterocyclic compounds of general formula (I) wherein: R1 represents a (CH2)n—NH2 radical, n being equal to 1 or 2; R2 represents a hydrogen atom; R3 and R4 form together a nitrogen-containing heterocycle with aromaticity with 5 apices containing 1, 2 or 3 nitrogen atoms, substituted on this nitrogen atom or one of these nitrogen atoms with a (CH2)m—(C(O))p—R5 group, m being equal to 0, 1, 2 or 3, p being equal to 0 or 1 and R5 representing a hydroxy group, in which case p is equal to 1, or an amino, (C1-C6)alkyl or di-(C1-C6)alkyl amino, a nitrogen-containing heterocycle with aromaticity with 5 or 6 apices containing 1 or 2 nitrogen atoms and if necessary, an oxygen or sulfur atom; it being understood that when the sub-group (C(O))p—R5 forms a carboxy, amino, (C1-C6) alkyl or di-(C1-C6) alkyl amino, group, m is different from 0 or 1; in free form or as zwitterions and salts with pharmaceutically acceptable mineral or organic bases and acids, to their pre
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: November 29, 2011
    Assignee: AstraZeneca AB
    Inventors: Maxime Lampilas, David Rowlands, Benoit Ledoussal, Marie-Edith Gourdel, Emilie Renaud, Camille Pierres, Adel Kebsi
  • Nitrogenous heterocyclic compounds, preparation thereof and use thereof as antibacterial medicaments
    Patent number: 8063219
    Abstract: The invention concerns nitrogenated heterocyclic compounds, their preparation and use as antibacterial drugs, compounds of general formula (I) wherein R1 represents a (CH2)n-NHR2 or (CH2)n-NHR radical, where R is a (C1-C6) alkyl and n is equal to 1 or 2; R2 represents a hydrogen atom; R3 and R4 together form an aromatic nitrogenated heterocycle with 5 apexes with 1, 2 or 3 nitrogen atoms optionally substituted by one or several R? groups, R? being selected in the group composed of a hydrogen atom and alkyl radicals with 1 to 6 carbon atoms; in free form, as zwitterions, and in the form of salts of pharmaceutically acceptable inorganic or organic bases and acids.
    Type: Grant
    Filed: April 11, 2008
    Date of Patent: November 22, 2011
    Assignee: Novexel
    Inventors: Maxime Lampilas, David Alun Rowlands, Adel Kebsi, Benoit Ledoussal, Camille Pierres
  • AZABICYCLIC COMPOUNDS, PREPARATION THEREOF AND USE OF SAME AS DRUGS, ESPECIALLY BETA-LACTAMASE INHIBITORS
    Publication number: 20110046102
    Abstract: The invention concerns the compounds meeting formula (I: wherein one of R1 and R2 is a hydrogen and the other a fluorine or both represent a fluorine, in free form, in the form of zwitterions and of salts with pharmaceutically acceptable mineral or organic bases, the preparation thereof and their use as medicinal products inhibiting the action of ?-lactamases by pathogenic bacteria.
    Type: Application
    Filed: April 24, 2009
    Publication date: February 24, 2011
    Applicant: Novexel
    Inventors: Benoit Ledoussal, Marie-Edith Gourdel
  • Antimicrobial quinolones, their compositions and uses
    Patent number: 7868021
    Abstract: Compounds having the general structure: which are effective antimicrobial agents.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: January 11, 2011
    Assignee: Warner Chilcott Company, LLC
    Inventors: Benoit Ledoussal, Ji-In Kim Almstead, Jeffery Lyle Gray
  • NOVEL HETEROCYCLIC NITROGENOUS COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIBACTERIAL MEDICAMENTS
    Publication number: 20100093784
    Abstract: The invention relates to nitrogenous heterocyclic compounds of formula in which: R1 represents hydrogen, —(CH2)m—NH2, —(CH2)m—NH(C1-C6)alk, —(CH2)m—N(C1-C6)alk2, —(CH2)m—NH—C(NH)NH2 or —(CH2)m—NH—CH?NH, m is equal to 1 or 2; R2 and R3 together form a nitrogenous heterocycle of aromatic character with 5 vertices containing 1, 2 or 3 nitrogen atoms, substituted on a nitrogen atom by R4; R4 represents hydrogen, C1-C6)alk or a chain of formula: -(A)n-(NH)o—(CH2)p—(CHR?)qR? A represents C?O, C?NH or SO2; R? represents hydrogen or carboxy.
    Type: Application
    Filed: August 5, 2009
    Publication date: April 15, 2010
    Applicant: Novexel
    Inventors: Benoit Ledoussal, Marie-Edith Gourdel, Emilie Renaud, Camille Pierres, Adel Kebsi
  • NOVEL NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, THEIR PREPARATION AND THEIR USE AS ANTIBACTERIAL DRUGS
    Publication number: 20100087648
    Abstract: The invention relates to nitrogen-containing heterocyclic compounds of general formula (I) wherein: R1 represents a (CH2)n—NH2 radical, n being equal to 1 or 2; R2 represents a hydrogen atom; R3 and R4 form together a nitrogen-containing heterocycle with aromaticity with 5 apices containing 1, 2 or 3 nitrogen atoms, substituted on this nitrogen atom or one of these nitrogen atoms with a (CH2)m—(C(O))p—R5 group, m being equal to 0, 1, 2 or 3, p being equal to 0 or 1 and R5 representing a hydroxy group, in which case p is equal to 1, or an amino, (C1-C6)alkyl or di-(C1-C6)alkyl amino, a nitrogen-containing heterocycle with aromaticity with 5 or 6 apices containing 1 or 2 nitrogen atoms and if necessary, an oxygen or sulfur atom; it being understood that when the sub-group (C(O))p—R5 forms a carboxy, amino, (C1-C6) alkyl or di-(C1-C6) alkyl amino, group, m is different from 0 or 1; in free form or as zwitterions and salts with pharmaceutically acceptable mineral or organic bases and acids, to their prepara
    Type: Application
    Filed: August 5, 2009
    Publication date: April 8, 2010
    Applicant: Novexel
    Inventors: Maxime Lampilas, David Rowlands, Benoit Ledoussal, Marie-Edith Gourdel, Emilie Renaud, Camille Pierres, Adel Kebsi