Patents by Inventor Benoit Marabout

Benoit Marabout has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of -heterocyclylmethylbenzamides in therapeutics
    Patent number: 8513246
    Abstract: The invention relates to use of compositions in therapeutics containing a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein.
    Type: Grant
    Filed: October 5, 2009
    Date of Patent: August 20, 2013
    Assignee: SANOFI
    Inventors: Gihad Dargazanli, Genevieve Estenne-Bouhtou, Pascale Magat, Benoit Marabout, Pierre Roger
  • N-[phenyl(piperidin-2-yl)methyl]benzamide derivatives, preparation thereof, and use thereof in therapy
    Patent number: 7951821
    Abstract: This invention discloses and claims a compound of general formula (I) in which R1 represents either a hydrogen atom, or an optionally substituted alkyl group, or a cycloalkylalkyl group, or an optionally substituted phenylalkyl group, or an alkenyl group, X represents a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, R2 represents one or more substituents chosen from halogen atoms, optionally substituted alkoxy and optionally substituted amino. The compounds of this invention exhibit therapeutic utility.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: May 31, 2011
    Assignee: sanofi-aventis
    Inventors: Gihad Dargazanli, Genevieve Estenne-Bouhtou, Benoit Marabout, Pierre Roger, Mireille Sevrin
  • USE OF N-HETEROCYCLYLMETHYLBENZAMIDES IN THERAPEUTICS
    Publication number: 20100022548
    Abstract: The invention relates to use of compositions in therapeutics containing a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein.
    Type: Application
    Filed: October 5, 2009
    Publication date: January 28, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Gihad DARGAZANLI, Genevieve ESTENNE-BOUHTOU, Pascale MAGAT, Benoit MARABOUT, Pierre ROGER
  • Derivatives of -heterocyclylmethylbenzamides, preparation method thereof and application of same in therapeutics
    Patent number: 7619089
    Abstract: The invention relates to compositions comprising a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein. Also disclosed and claimed in certain of the embodiments herein are the methods of preparation of compound of formula (I) and its use in therapeutics.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: November 17, 2009
    Assignee: Sanofi-Aventis
    Inventors: Gihad Dargazanli, Genevieve Estenne-Bouhtou, Pascale Magat, Benoit Marabout, Pierre Roger
  • 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE
    Publication number: 20090275576
    Abstract: A subject-matter of the invention is the compounds of general formula (I) in which X represents a hydrogen or halogen atom; R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 and R3 each represent, independently of one another, a hydrogen atom or a (C1-C4)alkyl group or else R2 and R3 form, with the nitrogen atom which carries them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type, it being possible for the heteroaromatic group to carry one or more halogen atoms and/or one or more (C1-C4)alkyl or (C1-C4)alkoxy groups; in the form of bases, of addition salts with acids, of solvates or of hydrates, the pharmaceutical compositions comprising them, processes for their preparation and synthetic intermediates.
    Type: Application
    Filed: June 19, 2009
    Publication date: November 5, 2009
    Applicant: sanofi-aventis
    Inventors: Philippe BURNIER, Jacques FROISSANT, Benoit MARABOUT, Frank MARGUET, Frederic PUECH
  • 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide derivatives, their preparation and therapeutic use
    Patent number: 7569567
    Abstract: A subject-matter of the invention is the compounds of general formula (I) in which X represents a hydrogen or halogen atom; R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 and R3 each represent, independently of one another, a hydrogen atom or a (C1-C4)alkyl group or else R2 and R3 form, with the nitrogen atom which carries them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type, it being possible for the heteroaromatic group to carry one or more halogen atoms and/or one or more (C1-C4) alkyl or (C1-C4) alkoxy groups; in the form of bases, of addition salts with acids, of solvates or of hydrates, the pharmaceutical compositions comprising them, processes for their preparation and synthetic intermediates.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: August 4, 2009
    Assignee: sanofi-aventis
    Inventors: Philippe Burnier, Jacques Froissant, Benoit Marabout, Frank Marguet, Frederic Puech
  • 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics
    Publication number: 20080255129
    Abstract: The invention discloses and claims therapeutic uses of compounds of general formula (I) Wherein X, R1, R2 and R3 are as described herein. The invention further discloses processes for preparing them, and novel intermediates therefor.
    Type: Application
    Filed: June 20, 2008
    Publication date: October 16, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Jacques FROISSANT, Benoit MARABOUT, Frank MARGUET, Frederic PUECH
  • 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide Derivatives, Their Preparation and Therapeutic Use
    Publication number: 20080249098
    Abstract: A subject-matter of the invention is the compounds of general formula (I) in which X represents a hydrogen or halogen atom; R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 and R3 each represent, independently of one another, a hydrogen atom or a (C1-C4)alkyl group or else R2 and R3 form, with the nitrogen atom which carries them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type, it being possible for the heteroaromatic group to carry one or more halogen atoms and/or one or more (C1-C4) alkyl or (C1-C4) alkoxy groups; in the form of bases, of addition salts with acids, of solvates or of hydrates, the pharmaceutical compositions comprising them, processes for their preparation and synthetic intermediates.
    Type: Application
    Filed: June 17, 2008
    Publication date: October 9, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Philippe Burnier, Jacques Froissant, Benoit Marabout, Frank Marguet, Frederic Puech
  • 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics
    Patent number: 7405306
    Abstract: The invention discloses and claims therapeutic uses of compounds of general formula (I) Wherein X, R1, R2 and R3 are as described herein. The invention further discloses processes for preparing them, and novel intermediates therefor.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: July 29, 2008
    Assignee: Sanofi-Aventis
    Inventors: Jacques Froissant, Benoit Marabout, Frank Marguet, Frederic Puech
  • 3-heteroaryl-3,5-dihydro-4-oxo-4-pyridazino[4,5-B]indole-1-carboxamide derivatives, their preparation and therapeutic use
    Patent number: 7402682
    Abstract: A subject-matter of the invention is the compounds of general formula (I) in which X represents a hydrogen or halogen atom; R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 and R3 each represent, independently of one another, a hydrogen atom or a (C1-C4)alkyl group or else R2 and R3 form, with the nitrogen atom which carries them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type, it being possible for the heteroaromatic group to carry one or more halogen atoms and/or one or more (C1-C4)alkyl or (C1-C4)alkoxy groups; in the form of bases, of addition salts with acids, of solvates or of hydrates, the pharmaceutical compositions comprising them, processes for their preparation and synthetic intermediates.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: July 22, 2008
    Assignee: Sanofi-Aventis
    Inventors: Philippe Burnier, Jacques Froissant, Benoit Marabout, Frank Marguet, Frederic Puech
  • 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics
    Publication number: 20080076775
    Abstract: The invention discloses and claims therapeutic uses of compounds of general formula (I) Wherein X, R1, R2 and R3 are as described herein. The invention further discloses processes for preparing them, and novel intermediates therefor.
    Type: Application
    Filed: October 4, 2007
    Publication date: March 27, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Jacques FROISSANT, Benoit MARABOUT, Frank MARGUET, Frederic PUECH
  • DERIVATIVES OF N-HETEROCYCLYLMETHYLBENZAMIDES, PREPARATION METHOD THEREOF AND APPLICATION OF SAME IN THERAPEUTICS
    Publication number: 20080070941
    Abstract: The invention relates to compositions comprising a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein. Also disclosed and claimed in certain of the embodiments herein are the methods of preparation of compound of formula (I) and its use in therapeutics.
    Type: Application
    Filed: September 20, 2007
    Publication date: March 20, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Gihad DARGAZANLI, Genevieve ESTENNE-BOUHTOU, Pascale MAGAT, Benoit MARABOUT, Pierre ROGER
  • 3-heteroaryl-3,5-dihydro-4-oxo-4-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics
    Patent number: 7323467
    Abstract: The invention discloses and claims therapeutic uses of compounds of general formula (I) Wherein X, R1, R2 and R3 are as described herein. The invention further discloses processes for preparing them, and novel intermediates therefor.
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: January 29, 2008
    Assignee: Sanofi-Aventis
    Inventors: Jacques Froissant, Benoit Marabout, Frank Marguet, Frederic Puech
  • Derivatives of N-heterocyclylmethylbenzamides, preparation method thereof and application of same in therapeutics
    Patent number: 7288656
    Abstract: The invention relates to a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein. Also disclosed and claimed in certain of the embodiments herein are the methods of preparation of compound of formula (I) and its use in therapeutics.
    Type: Grant
    Filed: April 14, 2006
    Date of Patent: October 30, 2007
    Assignee: Sanofi-Aventis
    Inventors: Gihad Dargazanli, Genevieve Estenne-Bouhtou, Pascale Magat, Benoit Marabout, Pierre Roger
  • 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5 b]indole-1-acetamide derivatives, their preparation and their application in therapeutics
    Publication number: 20070219202
    Abstract: The invention discloses and claims therapeutic uses of compounds of general formula (I) Wherein X, R1, R2 and R3 are as described herein. The invention further discloses processes for preparing them, and novel intermediates therefor.
    Type: Application
    Filed: May 16, 2007
    Publication date: September 20, 2007
    Applicant: SANOFI-AVENTIS
    Inventors: Jacques FROISSANT, Benoit MARABOUT, Frank MARGUET, Frederic PUECH
  • Use of N-[Phenyl(piperidin-2-yl)methyl]benzamide derivatives in therapy
    Publication number: 20070197601
    Abstract: The present invention discloses and claims therapeutic use of a series of compounds of general formula (I) in which A, X and R2 are as described herein. Specifically, the compounds of formula (I) exhibit a particular activity as specific inhibitors of the glycine transporters glyt1 and/or glty2.
    Type: Application
    Filed: April 3, 2007
    Publication date: August 23, 2007
    Applicant: SANOFI-AVENTIS
    Inventors: Gihad DARGAZANLI, Genevieve ESTENNE-BOUHTOU, Pascale MAGAT, Benoit MARABOUT, Florence MEDAISKO, Pierre ROGER, Mireille SEVRIN, Corinne VERONIQUE
  • N-[PHENYL(PIPERIDIN-2-YL)METHYL]BENZAMIDE DERIVATIVES, PREPARATION THEREOF, AND USE THEREOF IN THERAPY
    Publication number: 20070155789
    Abstract: This invention discloses and claims a compound of general formula (I) in which R1 represents either a hydrogen atom, or an optionally substituted alkyl group, or a cycloalkylalkyl group, or an optionally substituted phenylalkyl group, or an alkenyl group, X represents a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, R2 represents one or more substituents chosen from halogen atoms, optionally substituted alkoxy and optionally substituted amino. The compounds of this invention exhibit therapeutic utility.
    Type: Application
    Filed: March 1, 2007
    Publication date: July 5, 2007
    Applicant: SANOFI-AVENTIS
    Inventors: Gihad DARGAZANLI, Genevieve ESTENNE-BOUHTOU, Benoit MARABOUT, Pierre ROGER, Mireille SEVRIN
  • Derivatives of N-heterocyclylmethylbenzamides, prepartion method thereof and application of same in therapeutics
    Publication number: 20060264441
    Abstract: The invention relates to a compound having general formula (I): Wherein R, R1, R2, X and n are as described herein. Also disclosed and claimed in certain of the embodiments herein are the methods of preparation of compound of formula (I)and its use in therapeutics.
    Type: Application
    Filed: April 14, 2006
    Publication date: November 23, 2006
    Applicant: Sanofi-aventis
    Inventors: Gihad Dargazanli, Genevieve Estenne-Bouhtou, Pascale Magat, Benoit Marabout, Pierre Roger
  • 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE
    Publication number: 20060241116
    Abstract: A subject-matter of the invention is the compounds of general formula (I) in which X represents a hydrogen or halogen atom; R1 represents a hydrogen atom or a (C1-C4)alkyl group; R2 and R3 each represent, independently of one another, a hydrogen atom or a (C1-C4)alkyl group or else R2 and R3 form, with the nitrogen atom which carries them, a pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl group; and Het represents a heteroaromatic group of pyridinyl, 1-oxidopyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type, it being possible for the heteroaromatic group to carry one or more halogen atoms and/or one or more (C1-C4)alkyl or (C1-C4)alkoxy groups; in the form of bases, of addition salts with acids, of solvates or of hydrates, the pharmaceutical compositions comprising them, processes for their preparation and synthetic intermediates.
    Type: Application
    Filed: June 29, 2006
    Publication date: October 26, 2006
    Applicant: SANOFI-AVENTIS
    Inventors: Philippe BURNIER, Jacques FROISSANT, Benoit MARABOUT, Frank MARGUET, Frederic PUECH
  • Derivative of n-[phenyl(piperidin-2-yl)methyl]benzamide, the preparation method thereof and application of same in therapeutics
    Publication number: 20050159450
    Abstract: Compound of general formula (I) in which A represents either a group of formula N—R1 in which R1 represents a hydrogen atom, an alkyl group, a cycloalkyl group, a phenylalkyl group, an alkenyl group or an alkynyl group, or a group of formula N+(O?)R1 in which R1 is as defined above, or alternatively a group of formula N+(R?)R1 in which R? represents an alkyl group and R1 is as defined above, X represents a hydrogen atom or one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, R2 represents a hydrogen atom, one or more substituents chosen from halogen atoms and trifluoromethyl, alkyl and alkoxy groups, amino groups of formula NR3R4 in which R3 and R4 each represent a hydrogen atom or an alkyl group, or form with the nitrogen atom carrying them a pyrrolidine, piperidine or morpholine ring, or an optionally substituted phenyl group. Application in therapy.
    Type: Application
    Filed: April 17, 2003
    Publication date: July 21, 2005
    Inventors: Gihad Dargazanli, Genevieve Estenne-Bouhtou, Pascale Magat, Benoit Marabout, Florence Medaisko, Pierre Roger, Mireille Sevrin, Corinne Veronique