Abstract: A pre-polymer having activated and functionalized groups on a polymeric backbone is disclosed. The polymeric backbone has the formula (-A-B-)n, wherein A is derived from a polyol and B is derived from a polyacid, and n is greater than 1. The polyol may be a triol used with a diacid, or a diol used with a triacid. The pre-polymer includes activated groups, such as acrylate groups, capable of forming crosslinks, and activated functionalized groups that include charged atoms obtained by reaction with a compound containing a charged or chargeable atom. In preferred embodiments, the activated functionalized groups include positively charged heteroatoms, such as nitrogen. Compositions comprising the pre-polymer may include additives and exhibit a zeta potential in the range of 0 to 45 mV. Methods for preparing the pre-polymer and methods for using compositions comprising the pre-polymer to adhere or seal tissue are also disclosed.

Abstract: A composition comprising a pre-polymer having activated and functionalized groups on a polymeric backbone is disclosed. The composition may be used in a method of adhering or sealing tissue, or for adhering a medical device to the surface of a tissue. The composition has improved adhesive and sealant properties and comprises a pre-polymer comprising a polymeric unit of the general formula (-A-B-)n. A represents a substituted or unsubstituted polyol, B represents a substituted or unsubstituted polyacid, and n represents an integer greater than 1. Additionally, the composition has a zeta potential in the range of 0 to 45 mV.

Abstract: A composition comprising a pre-polymer having activated and functionalized groups on a polymeric backbone is disclosed. The composition may be used in a method of adhering or sealing tissue, or for adhering a medical device to the surface of a tissue.