Abstract: The invention provides a crystalline imidazo[4,5-b]pyridine compound, pharmaceutical compositions, methods of inhibiting tropomyosin-related kinase and/or c-FMS, and methods of treating medical diseases and conditions, such as pain.

Abstract: A propeller blade angle control circuit for a turboprop engine includes a propeller control unit controlling a supply of oil to modify an angle of propeller blades, a pump located upstream of the propeller control unit and providing the supply of oil from an engine oil return system to the propeller control unit, and a flow regulator between the pump and the propeller control unit, the flow regulator modulating a supply of oil to the propeller control unit. A bypass, downstream of the pump in the propeller blade angle control circuit, has an inlet fluidly coupled to the pump. The bypass is operable between a closed position and an open position in which a portion of the oil supplied to the propeller control unit is diverted away from the propeller blade angle control circuit. The open position is engaged when an oil pressure reaches a predetermined threshold.

Abstract: The invention provides a crystalline imidazo[4,5-b]pyridine compound, pharmaceutical compositions, methods of inhibiting tropomyosin-related kinase and/or c-FMS, and methods of treating medical diseases and conditions, such as pain.

Abstract: The invention provides a crystalline imidazo[4,5-b]pyridine compound, pharmaceutical compositions, methods of inhibiting tropomyosin-related kinase and/or c-FMS, and methods of treating medical diseases and conditions, such as pain.

Abstract: The instrumented device comprises a body to be attached to a mixing valve producing a mixed fluid by blending hot and cold fluids. The body defines a main channel and a bypass channel, provided for the outflow of the mixed fluid through the body. The device comprises a turbine arranged in the main channel, being bypassed by the bypass channel, such that, as soon as the flow rate of the mixed fluid flowing through the body is non-zero, all or a portion of the mixed fluid flowing through the body passes through the main channel passing through the turbine and, at the same time, a portion of the mixed fluid flowing through the body is likely to bypass the turbine by flowing in the bypass channel between the upstream and the downstream of the turbine.

Abstract: The present disclosure relates to a compound of formula (1) as an anhydrate which is in a crystalline Form 2, characterized by having a powder-X-ray diffractogram displaying peaks expressed as degree 2-Theta angles at about 9.5; 11.8; 14.1; 14.6; 17.7 and 18.5 and a solid form thereof. The present disclosure also relates to processes for its preparation, as well as a medicament and a pharmaceutical composition comprising it. The present disclosure further concerns the anhydrate crystalline Form 2 of compound of formula (1) for use as a medicine and more particularly in the treatment of cancer.

Abstract: The present disclosure provides crystalline forms of a JAK2 inhibitor, compositions thereof and methods of treating a JAK2-mediated disorder.

Abstract: The present invention relates to a treatment method for reducing the bacterial content of a food and/or biological medium of interest containing lipid droplets, which method comprises the following steps: (a) a step of homogenization applied to said medium of interest, (b) a step of microfiltration applied to said homogenized medium of interest resulting from step (a), on a membrane having a cut-off threshold which allows at least some of said lipid droplets to penetrate into the permeate, while at the same time retaining at least some of said bacteria in the retentate, and (c) the recovery of said permeate resulting from step (b), constituting a homogenized food and/or biological medium in which the bacterial content is lower than in the medium before the implementation of said method.

Abstract: Fumarate salt of 4-bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate, crystalline forms thereof, methods of preparation thereof, and therapeutic use thereof.

Abstract: The present invention relates to a treatment method for reducing the bacterial content of a food and/or biological medium of interest containing lipid droplets, which method comprises the following steps: (a) a step of homogenization applied to said medium of interest, (b) a step of microfiltration applied to said homogenized medium of interest resulting from step (a), on a membrane having a cut-off threshold which allows at least some of said lipid droplets to penetrate into the permeate, while at the same time retaining at least some of said bacteria in the retentate, and (c) the recovery of said permeate resulting from step (b), constituting a homogenized food and/or biological medium in which the bacterial content is lower than in the medium before the implementation of said method.

Abstract: Fumarate salt of 4-bromophenyl 1,4-diazabicyclo[3.2.2]nonane-4-carboxylate, crystalline forms thereof, methods of preparation thereof, and therapeutic use thereof.