Abstract: In some embodiments the present invention provides methods useful for the treatment of MMR-proficient and/or microsatellite stable (MSS) cancers and also useful for enhancing the immunogenicity of MMR-proficient and/or microsatellite stable (MSS) cancer cells, enhancing the sensitivity of MMR-proficient and/or microsatellite stable (MSS) cancer cells to immune checkpoint blockade, inducing an MMR-deficient mutational signature in MMR-proficient and/or microsatellite stable (MSS) cancer cells, and/or increasing the frequency of both missense and InDel mutations in MMR-proficient and/or microsatellite stable (MSS) cancer cells. In some embodiments such methods involve administration of a combination of temozolomide and cisplatin, or a combination of temozolomide, cisplatin and an immune checkpoint inhibitor, to a subject in need thereof.

Abstract: A method of monitoring the transport of flat copies along transport paths in a folder includes selecting sensors for detecting at least one of the presence and the absence of copies, depending upon the folding mode of the folder; determining by transmitters the number of copies that have entered the folder, and comparing the number of copies present in the folder with the number of copies detected by the sensors; a device for performing the method; a folder including the device; and a rotary printing machine in combination with the folder.

Abstract: The plant (1) comprises at least three assemblies (10, 11, 12) arranged one beside the other, namely a first assembly (10) comprising a medium-pressure column (2), a second assembly (11) comprising a low-pressure column (3), and a third assembly (12) comprising a heat-exchange line (5). The plant further comprises a liquid pump (6) for making a liquid flow between one of the columns (3) and the vaporizer-condenser (4). Application to the distilling of air using columns with structured interior packing.