Abstract: An assembly for a hearing aid is disclosed. The hearing aid with the assembly includes an in the ear part and a behind the ear part and a part mechanically interconnecting the two parts. In the interconnection, a flexible substrate is arranged. The flexible substrate includes conductive paths. The conductive paths may be used for communication between the in the ear part and the behind the ear part, and/or for an antenna function.

Abstract: An assembly for a hearing aid is disclosed. The hearing aid with the assembly comprises an in the ear part and a behind the ear part and a part mechanically interconnecting the two parts. In the interconnection, a flexible substrate is arranged. The flexible substrate comprises conductive paths. The conductive paths may be used for communication between the in the ear part and the behind the ear part, and/or for an antenna function.

Abstract: A hearing aid for placement on the head. The hearing aid includes a first part comprising an acoustic input transducer adapted to convert an ambient sound picked up at an ear of the user to an electric signal, a signal processor adapted to process the electric signal according to specifications of the user into a processed electric signal, and an output transducer adapted to convert the processed electric signal into a transmission signal, and a second part linkable to said first part by magnetic forces and comprising a receiver adapted to receive the transmission signal and convert the transmission signal to an output signal perceivable as sound by the user. Said first part comprises a receptacle adapted to receive an insert element, said insert element comprising protrusions configured for engaging with a recess of said first part by rotating the insert element relative to said first part.

Abstract: A hearing aid for placement on the head. The hearing aid includes a first part comprising an acoustic input transducer adapted to convert an ambient sound picked up at an ear of the user to an electric signal, a signal processor adapted to process the electric signal according to specifications of the user into a processed electric signal, and an output transducer adapted to convert the processed electric signal into a transmission signal, and a second part linkable to said first part by magnetic forces and comprising a receiver adapted to receive the transmission signal and convert the transmission signal to an output signal perceivable as sound by the user. Said first part comprises a receptacle adapted to receive an insert element, said insert element comprising protrusions configured for engaging with a recess of said first part by rotating the insert element relative to said first part.

Abstract: A hearing aid for placement on the head. The hearing aid includes a first part comprising an acoustic input transducer adapted to convert an ambient sound picked up at an ear of the user to an electric signal, a signal processor adapted to process the electric signal according to specifications of the user into a processed electric signal, and an output transducer adapted to convert the processed electric signal into a transmission signal, and a second part linkable to said first part by magnetic forces and comprising a receiver adapted to receive the transmission signal and convert the transmission signal to an output signal perceivable as sound by the user. Said first part comprises a receptacle adapted to receive an insert element, said insert element comprising protrusions configured for engaging with a recess of said first part by rotating the insert element relative to said first part.

Abstract: An assembly for a hearing aid is disclosed. The hearing aid with the assembly comprises an in the ear part and a behind the ear part and a part mechanically interconnecting the two parts. In the interconnection, a flexible substrate is arranged. The flexible substrate comprises conductive paths. The conductive paths may be used for communication between the in the ear part and the behind the ear part, and/or for an antenna function.

Abstract: An assembly for a hearing aid is disclosed. The hearing aid with the assembly comprises an in the ear part and a behind the ear part and a part mechanically interconnecting the two parts. In the interconnection, a flexible substrate is arranged. The flexible substrate comprises conductive paths. The conductive paths may be used for communication between the in the ear part and the behind the ear part, and/or for an antenna function.

Abstract: A hearing aid for placement on the head. The hearing aid includes a first part comprising an acoustic input transducer adapted to convert an ambient sound picked up at an ear of the user to an electric signal, a signal processor adapted to process the electric signal according to specifications of the user into a processed electric signal, and an output transducer adapted to convert the processed electric signal into a transmission signal, and a second part linkable to said first part by magnetic forces and comprising a receiver adapted to receive the transmission signal and convert the transmission signal to an output signal perceivable as sound by the user. Said first part comprises a receptacle adapted to receive an insert element, said insert element comprising protrusions configured for engaging with a recess of said first part by rotating the insert element relative to said first part.

Abstract: An assembly for a hearing aid is disclosed. The hearing aid with the assembly comprises an in the ear part and a behind the ear part and a part mechanically interconnecting the two parts. In the interconnection, a flexible substrate is arranged. The flexible substrate comprises conductive paths. The conductive paths may be used for communication between the in the ear part and the behind the ear part, and/or for an antenna function.

Abstract: An assembly for a hearing aid is disclosed. The hearing aid with the assembly comprises an in the ear part and a behind the ear part and a part mechanically interconnecting the two parts. In the interconnection, a flexible substrate is arranged. The flexible substrate comprises conductive paths. The conductive paths may be used for communication between the in the ear part and the behind the ear part, and/or for an antenna function.

Abstract: An assembly for a hearing aid is disclosed. The hearing aid with the assembly comprises an in the ear part and a behind the ear part and a part mechanically interconnecting the two parts. In the interconnection, a flexible substrate is arranged. The flexible substrate comprises conductive paths. The conductive paths may be used for communication between the in the ear part and the behind the ear part, and/or for an antenna function.

Abstract: T cell receptors (TCRs) having the property of binding to a murine insulin-derived peptide, LYLVCGERG (SEQ ID NO:62), presented by the murine H-2Kd complex (LYLVCGERG-H-2Kd). The TCRs comprise at least one TCR ? chain variable domain and/or at least one TCR ? chain variable domain and have a KD for the LYLVCGERG-H-2Kd complex of less than or equal to 1 ?M and/or have an off-rate (koff) for the LYLVCGERG-H-2Kd complex of 0.5 S?1 or slower, and use of such TCRs as research tools.

Abstract: The present invention provides a superantigen quality control assay, particularly for SEA-E120, comprising incubating a standard amount of a superantigen-containing test sample with a standard amount of a soluble TCR which binds the superantigen, separating unbound TCR from the resultant superantigen/TCR-containing sample, quantifying the TCR bound in that sample, and comparing that result with a reference result characterising a control superantigen-containing sample. Also provided are soluble TCRs useful as reagents in said assay.

Abstract: This invention is directed to a method for inhibiting cytotoxic T lymphocyte (CTL) activity in which soluble CD8 is used as the inhibitor. The invention is further directed to soluble forms of the CD8 molecule which can be administered to a patient. The method of this invention is particularly useful for immunosuppressive therapy in which inhibition of CTL activity is desirable, for example, in patients undergoing transplantation.

Abstract: The present invention provides a soluble T cell receptor (sTCR), which comprises (i) all or part of a TCR $g(a) chain, except the transmembrane domain thereof, and (ii) all or part of a TCR $g(b) chain, except the transmembrane domain thereof. (i) and (ii) each comprise a functional variable domain and at least a part of the constant domain of the TCR chain, and are linked by a disulphide bond between constant domain residues which is not present in native TCR, characterised in that the sTCR recognises a CD1-antigen complex, a bacterial superantigen or a peptide-MHC/superantigen complex.

Abstract: A single chain T cell receptor (scTCR) comprising an a segment constituted by a TCR ? chain variable region sequence fused to the N terminus of a TCR ? chain constant region extracellular sequence, a ? segment constituted by a TCR ? chain variable region fused to the N terminus of a TCR ? chain constant region extracellular sequence, and a linker sequence linking the C terminus of the a segment to the N terminus of the ? segment, or vice versa, the constant region extracellular sequences of the ? and ? segments being linked by a disulfide bond, the length of the linker sequence and the position of the disulfide bond being such that the variable region sequences of the ? and ? segments are mutually orientated substantially as in native ?? T cell receptors. Complexes of two or more such scTCRs, and use of the scTCRs in therapy and in various screening applications are also disclosed.

Abstract: The present invention provides a multimers of class I Major Histocompatibility Complexes (MHCs) having a modified P2-microglobulin whose binding to CD8 is inhibited. Such MHCs are capable of inhibiting CD8+ T cell response, particularly by inducing apoptosis or anergy of the T cell. The invention also provides nucleic acids encoding such molecules, and the use of such multimers and nucleic acids in immunosuppressive therapy, in particular as inhibitors of cytotoxic T cell responses.

Abstract: The present invention relates to a synthetic multivalent T cell receptor complex for binding to a MHC-peptide complex, which multivalent T cell receptor complex comprises a plurality of T cell receptors specific for the MHC-peptide complex. It is preferred that the T cell receptors are refolded recombinant soluble T cell receptors. The synthetic multivalent T cell receptor complex can be used for delivering therapeutic agents or for detecting MHC-peptide complexes, and methods for such uses are also provided.

Abstract: A multivalent T cell receptor (TCR) complex comprising at least two TCRs, linked by a non-peptidic polymer chain or a peptidic linker sequence. Preferably the TCR complex comprises TCR heterodimers having a non-native disulfide bond between constant domain residues, said TCRs being linked via an optionally substituted, polyalkylene glycol linker. Therapeutic agents such as cytotoxic drugs may be attached to such complexes for targeted cell delivery. Such TCR complexes may be used in the diagnosis or treatment of cancer, infectious disease, or autoimmune disease.

Abstract: The present invention relates to a recombinant soluble T cell receptor. The T cell receptor (TCR) is refolded and comprises a recombinant TCR ? or ? chain extracellular domain having a first heterologous C-terminal dimerization peptide; and a recombinant TCR ? or ? chain extracellular domain having a second C-terminal dimerization peptide which is specifically heterodimerized with the first dimerization peptide to form a heterodimerization domain, which may be a coiled coil domain. The invention also provides nucleic acid sequences encoding the recombinant TCR and a method for producing the recombinant TCR. The TCR may be labelled with a detectable label so as to enable the detection of specific MHC-peptide complexes. Alternatively, it can be linked to a therapeutic agent such as a cytotoxic agent or an immunostimulating agent so as to deliver such an agent to the site of a specific MHC-peptide complex.