Abstract: A synovium on a chip device having: a cartridge housing, a central chamber embedded in the cartridge housing, at least one aperture fluidly connected to the central chamber, and a plurality of evenly spaced micropillars arranged in a substantially circular shape within the central chamber such that the central chamber is partitioned into at least a first inner region and a first outer region, wherein the first inner region includes endothelial cells configured to mimic a vascular network and the first outer region includes fibroblast-like synoviocytes (FLS) configured to mimic a synovium.