Patents by Inventor Benyi Li

Benyi Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prostate cancer treatment with glycogen synthase kinase-3beta inhibitors
    Publication number: 20070196514
    Abstract: A method of treating prostate cancers, including androgen refractory prostate cancers, using glycogen synthase kinase-3? inhibitors, such as lithium.
    Type: Application
    Filed: February 21, 2006
    Publication date: August 23, 2007
    Inventor: Benyi Li
  • Method for treating prostate cancer using siRNA duplex for androgen receptor
    Publication number: 20050164970
    Abstract: Interfering RNA duplexes directed to the androgen receptor associated with prostate cancer are provided. A method of treating prostate cancer using interfering RNA duplexes to mediate gene silencing is also provided.
    Type: Application
    Filed: December 22, 2004
    Publication date: July 28, 2005
    Inventor: Benyi Li
  • Bax degradation involvement in tumor survival and progression
    Patent number: 6692927
    Abstract: According to the present invention, there is provided an assay for determining Bax degradation activity in a patient sample. The assay includes a labeled Bax protein which is incubated with a protein extract from the sample and a detector for detecting a signal from the labeled Bax protein, whereby decreased signals compared to a control indicates Bax degradation activity. Also provided by the present invention is a method for assaying a tissue for Bax degradation activity for determining aggressiveness of a tumor, for screening compounds for inhibitors of Bax degradation activity and for determining efficacy of proteasome inhibitors to prevent Bax degradation including the steps of incubating the sample with a labeled Bax protein and detecting the presence of a label generated signal whereby decrease signal compared to a control indicates Bax degradation activity. A method for screening potential proteasome inhibitors and anticancer drugs for efficacy in preventing Bax degradation activity.
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: February 17, 2004
    Assignee: University of South Florida
    Inventors: Ping Dou, Benyi Li
  • Bax degradation involvement in tumor survival and progression
    Publication number: 20020102621
    Abstract: According to the present invention, there is provided an assay for determining Bax degradation activity in a patient sample. The assay includes a labeled Bax protein which is incubated with a protein extract from the sample and a detector for detecting a signal from the labeled Bax protein, whereby decreased signals compared to a control indicates Bax degradation activity. Also provided by the present invention is a method for assaying a tissue for Bax degradation activity for determining aggressiveness of a tumor, for screening compounds for inhibitors of Bax degradation activity and for determining efficacy of proteasome inhibitors to prevent Bax degradation including the steps of incubating the sample with a labeled Bax protein and detecting the presence of a label generated signal whereby decrease signal compared to a control indicates Bax degradation activity. A method for screening potential proteasome inhibitors and anticancer drugs for efficacy in preventing Bax degradation activity.
    Type: Application
    Filed: March 5, 2001
    Publication date: August 1, 2002
    Inventors: Ping Dou, Benyi Li