Patents by Inventor Benyong SHI
Benyong SHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230273448Abstract: An illumination system includes a surface configured to have an imaging target placed thereon, a light source, a beam splitter and at least a first mirror. The beam splitter is configured to split the beam of light from the light source and the first mirror is configured to reflect a first beam from the beam splitter onto the surface with the imaging target. An imaging system includes an imaging surface configured to have an imaging target placed thereon, a mirror, and a capturing device. The capturing device is configured to capture an image of the imaging target through a path of emitted light that extends from the imaging target, reflects off of the mirror, and to the capturing device. The mirror, the capturing device, or both are configured to move in a diagonal direction with respect to the imaging surface to reduce a length of the path of emitted light. Systems and methods to calibrate an imaging system to remove or reduce non-uniformities within images of samples due to imaging system properties.Type: ApplicationFiled: January 24, 2023Publication date: August 31, 2023Inventors: Mingsong CHEN, Benyong SHI, Tiong Han TOH, Huei Steven YEO
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Publication number: 20230110090Abstract: The present disclosure provides systems and methods of electroporation protocol optimization. Embodiments include electroporation machines capable of carrying out test protocols including multiple user-designated parameters. The protocols and parameters can be carried out on samples comprising cells, including portions of a sample, to determine optimum parameters for electroporation for different samples. The systems and methods of optimization preferably use electroporation cartridges, electroporation instruments and systems and methods of electroporation using these devices and systems. In some embodiments, electroporation cartridges comprise an electroporation chamber and electrodes.Type: ApplicationFiled: October 5, 2022Publication date: April 13, 2023Inventors: Mio Xiu Lu Ling, Harmon Cosme Sicat, JR., Joshua Mead, Benyong Shi, Li Yong Ong, Don Paul Kovarcik, Nektaria Andronikou
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Patent number: 11592679Abstract: An illumination system includes a surface configured to have an imaging target placed thereon, a light source, a beam splitter and at least a first mirror. The beam splitter is configured to split the beam of light from the light source and the first mirror is configured to reflect a first beam from the beam splitter onto the surface with the imaging target. An imaging system includes an imaging surface configured to have an imaging target placed thereon, a mirror, and a capturing device. The capturing device is configured to capture an image of the imaging target through a path of emitted light that extends from the imaging target, reflects off of the mirror, and to the capturing device. The mirror, the capturing device, or both are configured to move in a diagonal direction with respect to the imaging surface to reduce a length of the path of emitted light. Systems and methods to calibrate an imaging system to remove or reduce non-uniformities within images of samples due to imaging system properties.Type: GrantFiled: October 13, 2017Date of Patent: February 28, 2023Assignee: LIFE TECHNOLOGIES HOLDINGS PTE LIMITEDInventors: Mingsong Chen, Benyong Shi, Tiong Han Toh, Huei Steven Yeo
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Publication number: 20210123009Abstract: The present disclosure provides electroporation cartridges for single use electroporation as well as electroporation cartridges for automated batch processing, electroporation instruments and systems and methods of electroporation using these devices and systems. In some embodiments, electroporation cartridges comprise an electroporation chamber defined by an elongate body, a first electrode at a proximal end and a second electrode at a distal end of a chamber. Electroporation systems of the disclosure include one or more components including a pulse generator, compartments for placing either flow-through or single use electroporation cartridges, components for storage of cells, cooling and pre-cooling mechanisms, removably insertable modular casings having compartments for holding and arranging electroporation system and reagent components, one or more pumps for moving sample through the system, and processors and controllers.Type: ApplicationFiled: October 23, 2020Publication date: April 29, 2021Inventors: Steven Huei YEO, Siu Wee HON, Han WEI, Yvonne PECK, Way Xuang LEE, Benyong SHI, Chee Wai CHAN, Beng Heng (Derrick) LIM, Dhanaraj SHANMUGAM, Stacey TEO, Jun Yan THAM, Kok Shyong CHONG, Li Yang LIM, Michael GORDON, Nektaria ANDRONIKOU, Chris ROSSMANN, Xavier DE Mollerat DU JEU, Ulrich FORKE
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Patent number: 10931872Abstract: A method to maximize use of the field of view for an imaging system is provided herein. An imaging device can be part of the imaging system and include a detection unit and an alignment unit. The method includes capturing an initial image of an object and then calculating a rotational angle and zoom factor for the object in order to maximize the object's footprint within the field of view. Once the calculations are complete a computer can instruct the detection and alignment units to reconfigure their orientations relative to the object.Type: GrantFiled: August 21, 2019Date of Patent: February 23, 2021Assignees: LIFE TECHNOLOGIES HOLDINGS PTE LIMITED, PIERCE BIOTECHNOLOGY, INC.Inventors: Yanpeng Cao, Suk Hong, Tiong Han Toh, Steven Yeo, Benyong Shi, Kok Siong Teo, Brian Webb
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Patent number: 10627638Abstract: An illumination system includes a surface configured to have an imaging target placed thereon, a light source, a beam splitter and at least a first mirror. The beam splitter is configured to split the beam of light from the light source and the first mirror is configured to reflect a first beam from the beam splitter onto the surface with the imaging target. An imaging system includes an imaging surface configured to have an imaging target placed thereon, a mirror, and a capturing device. The capturing device is configured to capture an image of the imaging target through a path of emitted light that extends from the imaging target, reflects off the mirror, and to the capturing device. The mirror, the capturing device, or both are configured to move in a diagonal direction with respect to the imaging surface to reduce a length of the path of emitted light. Systems and methods to calibrate an imaging system to remove or reduce non-uniformities within images of samples due to imaging system properties.Type: GrantFiled: September 5, 2018Date of Patent: April 21, 2020Assignee: LIFE TECHNOLOGIES HOLDING PTE LIMITEDInventors: Mingsong Chen, Benyong Shi, Tiong Han Toh, Steven Yeo, Soo Fan Phua
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Publication number: 20200112677Abstract: A method to maximize use of the field of view for an imaging system is provided herein. An imaging device can be part of the imaging system and include a detection unit and an alignment unit. The method includes capturing an initial image of an object and then calculating a rotational angle and zoom factor for the object in order to maximize the object's footprint within the field of view. Once the calculations are complete a computer can instruct the detection and alignment units to reconfigure their orientations relative to the object.Type: ApplicationFiled: August 21, 2019Publication date: April 9, 2020Inventors: Yanpeng Cao, Suk Hong, Tiong Han Toh, Steven Yeo, Benyong Shi, Kok Siong Teo, Brian Webb
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Patent number: 10432857Abstract: A method to maximize use of the field of view for an imaging system is provided herein. An imaging device can be part of the imaging system and include a detection unit and an alignment unit. The method includes capturing an initial image of an object and then calculating a rotational angle and zoom factor for the object in order to maximize the object's footprint within the field of view. Once the calculations are complete a computer can instruct the detection and alignment units to reconfigure their orientations relative to the object.Type: GrantFiled: October 13, 2017Date of Patent: October 1, 2019Assignees: LIFE TECHNOLOGIES HOLDINGS PTE LIMITED, PIERCE BIOTECHNOLOGY, INC.Inventors: Yanpeng Cao, Suk Hong, Tiong Han Toh, Steven Yeo, Benyong Shi, Kok Siong Teo, Brian Webb
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Publication number: 20190034755Abstract: Systems and methods generate a projected image at an optimal exposure time. Images are captured different exposure times. Pixels that satisfy an intensity threshold percentage for each image are selected. The intensity values of the selected pixels are then evaluated to determine whether the selected pixels are distributed above a lower intensity threshold and below an upper intensity threshold. The linear relationship is projected to determine an optimal exposure time that has an optimal exposure time duration that exceeds each exposure time duration associated with each of the captured images when the linear relationship exists between each of the captured images. A projected image associated with the optimal exposure time is generated from one or more of the captured images.Type: ApplicationFiled: October 3, 2018Publication date: January 31, 2019Inventors: Suk HONG, Nikki JARRETT, Eric HOMMEMA, Jason ARAVICH, Yanpeng CAO, Benyong SHI, Kok Siong TEO
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Publication number: 20180373049Abstract: An illumination system includes a surface configured to have an imaging target placed thereon, a light source, a beam splitter and at least a first mirror. The beam splitter is configured to split the beam of light from the light source and the first mirror is configured to reflect a first beam from the beam splitter onto the surface with the imaging target. An imaging system includes an imaging surface configured to have an imaging target placed thereon, a mirror, and a capturing device. The capturing device is configured to capture an image of the imaging target through a path of emitted light that extends from the imaging target, reflects off the mirror, and to the capturing device. The mirror, the capturing device, or both are configured to move in a diagonal direction with respect to the imaging surface to reduce a length of the path of emitted light. Systems and methods to calibrate an imaging system to remove or reduce non-uniformities within images of samples due to imaging system properties.Type: ApplicationFiled: September 5, 2018Publication date: December 27, 2018Inventors: Mingsong CHEN, Benyong SHI, Tiong Han TOH, Steven YEO, Soo Fan PHUA
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Patent number: 10115034Abstract: Systems and methods generate a projected image at an optimal exposure time. Images are captured different exposure times. Pixels that satisfy an intensity threshold percentage for each image are selected. The intensity values of the selected pixels are then evaluated to determine whether the selected pixels are distributed above a lower intensity threshold and below an upper intensity threshold. The linear relationship is projected to determine an optimal exposure time that has an optimal exposure time duration that exceeds each exposure time duration associated with each of the captured images when the linear relationship exists between each of the captured images. A projected image associated with the optimal exposure time is generated from one or more of the captured images.Type: GrantFiled: October 14, 2016Date of Patent: October 30, 2018Assignees: LIFE TECHNOLOGIES HOLDINGS PTE LIMITED, PIERCE BIOTECHNOLOGY, INC.Inventors: Suk Hong, Nikki Jarrett, Eric Hommema, Jason Aravich, Yanpeng Cao, Benyong Shi, Kok Siong Teo
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Publication number: 20180124313Abstract: A method to maximize use of the field of view for an imaging system is provided herein. An imaging device can be part of the imaging system and include a detection unit and an alignment unit. The method includes capturing an initial image of an object and then calculating a rotational angle and zoom factor for the object in order to maximize the object's footprint within the field of view. Once the calculations are complete a computer can instruct the detection and alignment units to reconfigure their orientations relative to the object.Type: ApplicationFiled: October 13, 2017Publication date: May 3, 2018Inventors: Yanpeng CAO, Suk HONG, Tiong Han TOH, Steven YEO, Benyong SHI, Kok Siong TEO, Brian WEBB
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Publication number: 20180120575Abstract: An illumination system includes a surface configured to have an imaging target placed thereon, a light source, a beam splitter and at least a first mirror. The beam splitter is configured to split the beam of light from the light source and the first mirror is configured to reflect a first beam from the beam splitter onto the surface with the imaging target. An imaging system includes an imaging surface configured to have an imaging target placed thereon, a mirror, and a capturing device. The capturing device is configured to capture an image of the imaging target through a path of emitted light that extends from the imaging target, reflects off of the mirror, and to the capturing device. The mirror, the capturing device, or both are configured to move in a diagonal direction with respect to the imaging surface to reduce a length of the path of emitted light. Systems and methods to calibrate an imaging system to remove or reduce non-uniformities within images of samples due to imaging system properties.Type: ApplicationFiled: October 13, 2017Publication date: May 3, 2018Inventors: Mingsong CHEN, Benyong SHI, Tiong Han TOH, Steven YEO
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Publication number: 20170103279Abstract: Systems and methods generate a projected image at an optimal exposure time. Images are captured different exposure times. Pixels that satisfy an intensity threshold percentage for each image are selected. The intensity values of the selected pixels are then evaluated to determine whether the selected pixels are distributed above a lower intensity threshold and below an upper intensity threshold. The linear relationship is projected to determine an optimal exposure time that has an optimal exposure time duration that exceeds each exposure time duration associated with each of the captured images when the linear relationship exists between each of the captured images. A projected image associated with the optimal exposure time is generated from one or more of the captured images.Type: ApplicationFiled: October 14, 2016Publication date: April 13, 2017Inventors: Suk HONG, Nikki JARRETT, Eric HOMMEMA, Jason ARAVICH, Yanpeng CAO, Benyong SHI, Kok Siong TEO