Patents by Inventor Beppino C. Giovanella

Beppino C. Giovanella has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for treating cancer with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
    Patent number: 6166029
    Abstract: A method of treating specific forms of cancer with water-insoluble 20(S)-camptothecin compounds with the closed-lactone ring intact and/or derivatives thereof is disclosed. The method includes administering the compounds intramuscularly, orally and transdermally.
    Type: Grant
    Filed: May 21, 1998
    Date of Patent: December 26, 2000
    Assignee: The Stehlin Foundation for Cancer Research
    Inventors: Beppino C. Giovanella, Hellmuth R. Hinz, Anthony J. Kozielski, John S. Stehlin
  • Methods of treating cancer using these derivatives
    Patent number: 6120793
    Abstract: Derivatives of camptothecin are disclosed and are represented by the general formula: ##STR1## wherein when R.sub.2 is H, R.sub.1 is a C.sub.2 -C.sub.4 alkyl group, a C.sub.6 -C.sub.15 alkyl group, a C.sub.3 -C.sub.8 cycloalkyl group, a C.sub.2 -C.sub.15 alkenyl group or a C.sub.2 -C.sub.15 epoxy group; and when R.sub.2 is a nitro group, R.sub.1 is a C.sub.1 -C.sub.15 alkl group, a C.sub.2 -C.sub.15 alkenyl group, a C.sub.3 -C.sub.8 cycloalkyl group, or an epoxy group. Processes for making these derivatives and for using them in cancer treatment are also disclosed.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: September 19, 2000
    Assignee: The Stehlin Foundation for Cancer Research
    Inventors: Zhisong Cao, Beppino C. Giovanella
  • Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
    Patent number: 6096336
    Abstract: Liposomal prodrugs include specific derivatives of camptothecin restrained by a liposomal delivery system. The derivatives of camptothecin are represented by the general formula: ##STR1## wherein when R.sub.2 is H, R.sub.1 is a C.sub.2 -C.sub.4 alkyl group, a C.sub.6 -C.sub.15 alkyl group, a C.sub.3 -C.sub.8 cycloalkyl group, a C.sub.2 -C.sub.15 alkenyl group or a C.sub.2 -C.sub.15 epoxy group; and when R.sub.2 is a nitro group, R.sub.1 is a C.sub.1 -C.sub.15 alkyl group, a C.sub.2 -C.sub.15 alkenyl group, a C.sub.3 -C.sub.8 cycloalkyl group, or an epoxy group. Processes for making these prodrugs and for using them in cancer treatment are also disclosed.
    Type: Grant
    Filed: August 3, 1999
    Date of Patent: August 1, 2000
    Assignee: The Stehlin Foundation for Cancer Research
    Inventors: Zhisong Cao, Beppino C. Giovanella
  • Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
    Patent number: 6080751
    Abstract: A method of treating human pancreatic cancer with water-insoluble 20(S)-camptothecin compounds with the closed-lactone ring intact and/or derivatives thereof is disclosed. The method includes preferably administering the compounds intramuscularly, orally, and transdermally.
    Type: Grant
    Filed: September 13, 1996
    Date of Patent: June 27, 2000
    Assignee: The Stehlin Foundation for Cancer Research
    Inventors: John S. Stehlin, Ethan A. Natelson, Beppino C. Giovanella, Anthony J. Kozielski
  • Derivatives of camptothecin and methods of treating cancer using these derivatives
    Patent number: 5968943
    Abstract: Derivatives of camptothecin are disclosed and are represented by the general formula: ##STR1## wherein when R.sub.2 is H, R.sub.1 is a C.sub.2 -C.sub.4 alkyl group, a C.sub.6 -C.sub.15 alkl group, a C.sub.3 -C.sub.8 cycloalkyl group, a C.sub.2 -C.sub.15 alkenyl group or a C.sub.2 -C.sub.15 epoxy group; and when R.sub.2 is a nitro group, R.sub.1 is a C.sub.1 -C.sub.15 alkyl group, a C.sub.2 -C.sub.15 alkenyl group, a C.sub.3 -C.sub.8 cycloalkyl group, or an epoxy group. Processes for mailing these derivatives and for using them in cancer treatment are also disclosed.
    Type: Grant
    Filed: February 25, 1998
    Date of Patent: October 19, 1999
    Assignee: The Stehlin Foundation for Cancer Research
    Inventors: Zhisong Cao, Beppino C. Giovanella
  • Method for treating cancer with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
    Patent number: 5889017
    Abstract: A method of treating specific forms of cancer with water-insoluble 20(S)-camptothecin compounds with the closed-lactone ring intact and/or derivatives thereof is disclosed. The method includes administering the compounds intramuscularly, orally and transdermally.
    Type: Grant
    Filed: December 17, 1996
    Date of Patent: March 30, 1999
    Assignee: The Stehlin Foundation for Cancer Research
    Inventors: Beppino C. Giovanella, Hellmuth R. Hinz, Anthony J. Kozielski
  • Derivatives of camptothecin and methods of treating cancer using these derivatives
    Patent number: 5731316
    Abstract: Derivatives of camptothecin are disclosed and are represented by the general formula: ##STR1## wherein when R.sub.2 is H, R.sub.1 is a C.sub.2 -C.sub.15 alkyl group, a C.sub.2 -C.sub.15 alkenyl group or an epoxy group; and when R.sub.2 is a nitro group, R.sub.1 is a C.sub.1 -C.sub.15 alkyl group, a C.sub.1 -C.sub.15 alkenyl group or an epoxy group. Processes for making these derivatives and for using them in cancer treatment are also disclosed.
    Type: Grant
    Filed: January 30, 1996
    Date of Patent: March 24, 1998
    Assignee: The Stehlin Foundation for Cancer Research
    Inventors: Zhisong Cao, Beppino C. Giovanella
  • Method for treating cancer with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
    Patent number: 5652244
    Abstract: A method of treating specific forms of cancer with water-insoluble 20(S)-camptothecin compounds with the closed-lactone ring intact and/or derivatives thereof is disclosed. The method includes administering the compounds intramuscularly, orally and transdermally.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 29, 1997
    Assignee: The Stehlin Foundation for Cancer Research
    Inventors: Beppino C. Giovanella, Hellmuth R. Hinz, Anthony J. Kozielski, John S. Stehlin
  • Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
    Patent number: 5552154
    Abstract: A method of treating specific forms of cancer with water-insoluble 20(S)-camptothecin compounds with the closed-lactone ring intact and/or derivatives thereof is disclosed. The method includes administering the compounds intramuscularly, orally and transdermally.
    Type: Grant
    Filed: September 7, 1994
    Date of Patent: September 3, 1996
    Assignee: The Stehlin Foundation for Cancer Research
    Inventors: Beppino C. Giovanella, Hellmuth R. Hinz, Anthony J. Kozielski, John S. Stehlin