Abstract: The present invention is in the field of a use of a bisphosphonate acid, specifically a salt thereof, or analogue thereof, or combinations thereof, in a medicament for naturally occurring diseases/disorders in a mammal, the mammal being selected from the orders of Perissodactyla, such as the family of Equidae (horses), (Cet)Artiodactyla, such as the family of Bovidae (cattle), and Carnivora, such as the families of Canidae (e.g. dogs) and Felidae (e.g. cats).

Abstract: The invention relates to a pharmaceutical composition, comprising (i) a compound comprising at least one carbohydrate and containing at least one sulphate, in combination with (ii) at least one non-protein or non-NA-strand compound, different from (i), that can activate PPAR, preferably PPAR?, and (iii) optionally, at least one pharmaceutically acceptable carrier. Preferably, the sulphated compounds include single sulphur containing agents like MSM or multiple sulphur containing agents like pentosan, Adequan®. The second part of the composition, is a PPAR? agonists chosen from the group of thiazolidinediones, NSAIDs, sulphonylureas and indoles, like for example indomethacin or pioglitazone.

Abstract: The present invention is in the field of a use of a bisphophosphonate acid, specifically a salt thereof, or analogue thereof, or combinations thereof, in a medicament for naturally occurring diseases/disorders in a mammal, the mammal being selected from the orders of Perissodactyla, such as the family of Equidae (horses), (Cet) Artiodactyla, such as the family of Bovidae (cattle), and Carnivora, such as the families of Canidae (e.g. dogs) and Felidae (e.g. cats).

Abstract: The invention relates to a pharmaceutical composition, comprising (i) a compound comprising at least one carbohydrate and containing at least one sulphate, in combination with (ii) at least one non-protein or non-NA-strand compound, different from (i), that can activate PPAR, preferably PPAR?, and (iii) optionally, at least one pharmaceutically acceptable carrier. Preferably, the sulphated compounds include single sulphur containing agents like MSM or multiple sulphur containing agents like pentosan, adequan. The second part of the composition, is a PPAR? agonists chosen from the group of thiazolidinediones, NSAIDs, sulphonylureas and indoles, like for example indomethacin or pioglitazone.