Patents by Inventor Berhan Mandefro

Berhan Mandefro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Neuromuscular junction
    Patent number: 11767513
    Abstract: The invention relates to culturing motor neuron cells together with skeletal muscle cells in a fluidic device under conditions whereby the interaction of these cells mimic the structure and function of the neuromuscular junction (NMJ) providing a NMJ-on-chip. Good viability, formation of myo-fibers and function of skeletal muscle cells on fluidic chips allow for measurements of muscle cell contractions. Embodiments of motor neurons co-cultures with contractile myo-fibers are contemplated for use with modeling diseases affecting NMJ's, e.g. Amyotrophic lateral sclerosis (ALS).
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: September 26, 2023
    Assignee: Cedars-Sinai Medical Center
    Inventors: Dhruv Sareen, Berhan Mandefro, Anjoscha Kaus
  • NEUROMUSCULAR JUNCTION
    Publication number: 20200071673
    Abstract: The invention relates to culturing motor neuron cells together with skeletal muscle cells in a fluidic device under conditions whereby the interaction of these cells mimic the structure and function of the neuromuscular junction (NMJ) providing a NMJ-on-chip. Good viability, formation of myo-fibers and function of skeletal muscle cells on fluidic chips allow for measurements of muscle cell contractions. Embodiments of motor neurons co-cultures with contractile myo-fibers are contemplated for use with modeling diseases affecting NMJ's, e.g. Amyotrophic lateral sclerosis (ALS).
    Type: Application
    Filed: March 14, 2018
    Publication date: March 5, 2020
    Applicant: CEDARS-SINAI MEDICAL CENTER
    Inventors: Dhruv SAREEN, Berhan MANDEFRO, Anjoscha KAUS
  • Neuromuscular Junction: NMJ-ON-CHIP
    Publication number: 20170226478
    Abstract: The invention relates to culturing motor neuron cells together with skeletal muscle cells in a fluidic device under conditions whereby the interaction of these cells mimic the structure and function of the neuromuscular junction (NMJ) providing a NMJ-on-chip. Good viability, formation of myo-fibers and function of skeletal muscle cells on fluidic chips allow for measurements of muscle cell contractions. Embodiments of motor neurons co-cultures with contractile myo-fibers are contemplated for use with modeling diseases affecting NMJ's, e.g. Amyotrophic lateral sclerosis (ALS).
    Type: Application
    Filed: March 14, 2017
    Publication date: August 10, 2017
    Inventors: Jordan Kerns, Norman Wen, Geraldine Hamilton, Christopher Hinojosa, Jacob Fraser, Catherine Karalis, Janna Nawroth, Dhruv Sareen, Anjoscha Kaus, Berhan Mandefro, Hyoung Shin Park, Ville Kujala