Patents by Inventor Bernadette Mandard

Bernadette Mandard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 4-acetoxy-2.alpha.-benzoyloxy-5.beta., 20-epoxy-1, 7.beta.-10.beta.-trihydroxy-9-oxo-tax-11-en-13.alpha.-yl(2R,3S)-3-tert-b utoxy-carbonYlamino-2-hydroxy-3-phenylpropionate trihydrate
    Patent number: 6022985
    Abstract: Process for the preparation of 4-acetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1,7.beta., 10.beta.-trihydroxy-9-oxo-tax-11-en-13.alpha.-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate, characterized in that the 4-acetoxy-2.alpha.-benzoyloxy-5.beta.,20-epoxy-1,7.beta.,10.beta.-trihydro xy-9-oxo-tax-11-en-13.alpha.-yl (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate is crystallized from a mixture of water and an aliphatic alcohol containing 1 to 3 carbon atoms, and then the product obtained is dried under defined conditions of temperature, pressure and humidity.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: February 8, 2000
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Rene Authelin, Jacques Doveze, Elie Fouque, Bernadette Mandard, Isabelle Taillepied
  • Process for obtaining 10-deacetylbaccatin III
    Patent number: 5453521
    Abstract: Process for producing 10-deacetylbaccatin III from the various parts of the yew (Taxus sp.) by extraction and selective crystallization from a methanolic extract of the plant mass.
    Type: Grant
    Filed: September 17, 1993
    Date of Patent: September 26, 1995
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Claude Gaullier, Bernadette Mandard, Rodolphe Margraff
  • Process for obtaining 10-deacetylbaccatin III
    Patent number: 5393895
    Abstract: This invention relates to a process for obtaining 10-deacetylbaccatin III from various parts of yew (Taxus sp.) by extraction and selective crystallization starting with a methanolic extract of the vegetable matter.
    Type: Grant
    Filed: January 27, 1993
    Date of Patent: February 28, 1995
    Assignee: Rhone-Poulenc Rorer, S.A.
    Inventors: Jean-Claude Gaullier, Bernadette Mandard, Rodolphe Margraff
  • Process for the preparation of cyclic sulphates
    Patent number: 5116999
    Abstract: Cyclic sulphates of formula: ##STR1## are prepared by oxidation of a cyclic sulphite of formula: ##STR2## with a hypohalite of an alkali or alkaline-earth metal and a catalytic quantity of a ruthernium derivative (RuO.sub.2, RuCl.sub.3). In formulae (I) and (II), R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are identical or different and each represents hydrogen, halogen, alkyl, alkoxy, aryl, aryloxy or alkoxycarbonyl.
    Type: Grant
    Filed: April 12, 1990
    Date of Patent: May 26, 1992
    Assignee: Rhone Poulenc Sante
    Inventors: Pierre Le Roy, Bernadette Mandard-Cazin
  • Process for the preparation of cyclic sulphates
    Patent number: 4960904
    Abstract: Cyclic sulphates of formula: ##STR1## are prepared by oxidation of a cyclic sulphite of formula: ##STR2## with a hypohalite of an alkali or alkaline-earth metal and a catalytic quantity of a ruthernium derivative (RuO.sub.2, RuCl.sub.3). In formulae (I) and (II), R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are identical or different and each represents hydrogen, halogen, alkyl, alkoxy, aryl, aryloxy or alkoxycarbonyl.
    Type: Grant
    Filed: September 6, 1989
    Date of Patent: October 2, 1990
    Assignee: Rhone-Poulenc Sante
    Inventors: Pierre Le Roy, Bernadette Mandard-Cazin
  • Process for preparing 1-hydroxyalkyl-5-nitroimidazoles
    Patent number: 4925952
    Abstract: Process for preparing 1-(hydroxyalkyl)nitroimidazoles of formula: ##STR1## which comprises reacting an alkylene sulphate of formula: ##STR2## with an imidazole derivative of formula: ##STR3## followed by hydrolyzing or alcoholyzing the product obtained. In the formulae (I) and (II), n is 2 or 3; in the formulae (I) and (III), R denotes hydrogen or hydrocarbon radical; and in the formula (III), X denotes hydrogen or a radical that can be removed by hydrolysis or alcoholysis.
    Type: Grant
    Filed: January 13, 1989
    Date of Patent: May 15, 1990
    Assignee: Rhone-Poulenc Sante
    Inventors: Viviane Massonneau, Michel Mulhauser, Albert Buforn, Bernadette Mandard-Cazin