Patents by Inventor Bernard Abramovici

Bernard Abramovici has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170319538
    Abstract: The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.
    Type: Application
    Filed: July 26, 2017
    Publication date: November 9, 2017
    Inventors: Bernard ABRAMOVICI, Jean-Claude GAUTIER, Jean-Claude GROMENIL, Jean-Marie MARRIER
  • Publication number: 20160338989
    Abstract: The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.
    Type: Application
    Filed: May 6, 2016
    Publication date: November 24, 2016
    Inventors: Bernard ABRAMOVICI, Jean-Claude GAUTIER, Jean-Claude GROMENIL, Jean-Marie MARRIER
  • Publication number: 20150196528
    Abstract: The disclosure relates to a pharmaceutical composition for oral administration, containing, as active principle, a benzofuran derivative having antiarrhythmic activity, in particular dronedarone and the pharmaceutically acceptable salts thereof, and at least one lipid carrier, said pharmaceutical composition being intended to be used in unit dosage form of the capsule type, in particular with a hard shell. This pharmaceutical composition and the dosage form comprising such a composition aim to limit the meal time effect following oral administration in humans. The lipid carrier allows: the solubilization of the active principle of the invention; and the shielding thereof from the negative effects of pH in the intestinal tract, thereby allowing same to be spared from the meal effect to a significant extent.
    Type: Application
    Filed: March 26, 2015
    Publication date: July 16, 2015
    Inventors: Bernard ABRAMOVICI, Stephane BEILLES, Sandra CHAMBONNET, Jean-Claude GAUTIER
  • Patent number: 9018250
    Abstract: The disclosure relates to a pharmaceutical composition for oral administration, containing, as active principle, a benzofuran derivative having antiarrhythmic activity, in particular dronedarone and the pharmaceutically acceptable salts thereof, and at least one lipid carrier, said pharmaceutical composition being intended to be used in unit dosage form of the capsule type, in particular with a hard shell. This pharmaceutical composition and the dosage form comprising such a composition aim to limit the meal time effect following oral administration in humans. The lipid carrier allows: the solubilization of the active principle of the invention; and the shielding thereof from the negative effects of pH in the intestinal tract, thereby allowing same to be spared from the meal effect to a significant extent.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: April 28, 2015
    Assignee: Sanofi
    Inventors: Bernard Abramovici, Stephane Beilles, Sandra Chambonnet, Jean-Claude Gautier
  • Publication number: 20130245115
    Abstract: The disclosure relates to a pharmaceutical composition for oral administration, containing, as active principle, a benzofuran derivative having antiarrhythmic activity, in particular dronedarone and the pharmaceutically acceptable salts thereof, and at least one lipid carrier, said pharmaceutical composition being intended to be used in unit dosage form of the capsule type, in particular with a hard shell. This pharmaceutical composition and the dosage form comprising such a composition aim to limit the meal time effect following oral administration in humans. The lipid carrier allows: the solubilization of the active principle of the invention; and the shielding thereof from the negative effects of pH in the intestinal tract, thereby allowing same to be spared from the meal effect to a significant extent.
    Type: Application
    Filed: May 6, 2013
    Publication date: September 19, 2013
    Applicant: SANOFI
    Inventors: Bernard ABRAMOVICI, Stephane BEILLES, Sandra CHAMBONNET, Jean-Claude GAUTIER
  • Patent number: 8318800
    Abstract: The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: November 27, 2012
    Assignee: Sanofi
    Inventors: Bernard Abramovici, Jean-Claude Gautier, Jean-Claude Gromenil, Jean-Marie Marrier
  • Publication number: 20080139645
    Abstract: The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.
    Type: Application
    Filed: December 13, 2007
    Publication date: June 12, 2008
    Applicant: SANOFI-AVENTIS
    Inventors: Bernard ABRAMOVICI, Jean-Claude GAUTIER, Jean-Claude GROMENIL, Jean-Marie MARRIER
  • Patent number: 7323493
    Abstract: The present invention relates to a solid pharmaceutical composition for oral administration characterized in that it comprises a benzofuran derivative with antiarrhythmic activity, or one of the pharmaceutically acceptable salts thereof, as an active principle, and a pharmaceutically acceptable nonionic hydrophilic surfactant optionally in combination with one or more pharmaceutical excipients.
    Type: Grant
    Filed: June 19, 1998
    Date of Patent: January 29, 2008
    Assignee: Sanofi-Aventis
    Inventors: Bernard Abramovici, Jean-Claude Gautier, Jean-Claude Gromenil, Jean-Marie Marrier
  • Patent number: 6893659
    Abstract: The pharmaceutical compositions for oral administration according to the invention contain 0.5% to 20% of N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide in microcrystalline form, and pharmaceutical excipients; they are formulated by wet granulation.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: May 17, 2005
    Assignee: Sanoti-Synthelabo
    Inventors: Bernard Abramovici, Christian Condamine, Jean-Claude Gromenil
  • Patent number: 6528539
    Abstract: The invention relates to a stable fumagillin formulation and to the method of use thereof in treating and/or combating intestinal infections.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: March 4, 2003
    Assignee: Sanofi-Synthelabo
    Inventors: Bernard Abramovici, Jean-Luc Dubois
  • Publication number: 20030003145
    Abstract: The pharmaceutical compositions for oral administration according to the invention contain 0.5% to 20% of N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide in microcrystalline form, and pharmaceutical excipients; they are formulated by wet granulation.
    Type: Application
    Filed: May 1, 2002
    Publication date: January 2, 2003
    Inventors: Bernard Abramovici, Christian Condamine, Jean-Claude Gromenil
  • Patent number: 6303626
    Abstract: The pharmaceutical formulations according to the invention contain from 0.5 to 50% by weight of a cyclic quaternary ammonium compound and pharmaceutically appropriate excipients and are formulated by wet granulation, preferably with polysorbate 80.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: October 16, 2001
    Assignee: Sanofi-Synthelabo
    Inventors: Bernard Abramovici, Xavier Boulenc, Jean-Claude Gautier, Pol Vilain
  • Patent number: 4980171
    Abstract: The invention relates to oral pharmaceutical compositions comprising a diphosphonic acid derivative and sodium laurylsulfate in the amount of 1.5 to 6% by weight, relative to the diphosphonic compound.
    Type: Grant
    Filed: April 6, 1989
    Date of Patent: December 25, 1990
    Assignee: Societe Anonyme dite : SANOFI
    Inventors: Jean-Pierre Fels, Jean-Claude Gromenil, Bernard Abramovici