Patents by Inventor Bernard Allan

Bernard Allan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for inhibiting cytochrome P450 family 7 subfamily a member 1 (CYP7A1) expression
    Patent number: 12553050
    Abstract: RNAi agents (e.g., CYP7A1 RNAi agents) for inhibiting the expression of the CYP7A1 gene, compositions including the RNAi agents conjugated to a targeting moiety, and methods of use are described. Also disclosed are pharmaceutical compositions including one or more RNAi agents (e.g., CYP7A1 RNAi agents). Delivery of the RNAi agent(s) to liver cells in vivo inhibits CYP7A1 gene expression and treats a CYP7A1 disease or a CYP7A1-associated disease.
    Type: Grant
    Filed: March 21, 2025
    Date of Patent: February 17, 2026
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Bernard Allan, Brian Ko, Pawan Kumar, Naim Nazef, Jason Pickens
  • COMPOSITIONS AND METHODS FOR INHIBITING CYTOCHROME P450 FAMILY 7 SUBFAMILY A MEMBER 1 (CYP7A1) EXPRESSION
    Publication number: 20250297260
    Abstract: RNAi agents (e.g., CYP7A1 RNAi agents) for inhibiting the expression of the CYP7A1 gene, compositions including the RNAi agents conjugated to a targeting moiety, and methods of use are described. Also disclosed are pharmaceutical compositions including one or more RNAi agents (e.g., CYP7A1 RNAi agents). Delivery of the RNAi agent(s) to liver cells in vivo inhibits CYP7A1 gene expression and treats a CYP7A1 disease or a CYP7A1-associated disease.
    Type: Application
    Filed: March 21, 2025
    Publication date: September 25, 2025
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Bernard Allan, Brian Ko, Pawan Kumar, Naim Nazef, Jason Pickens
  • Methods of diagnosing and treating diabetes and insulin resistance
    Publication number: 20070122802
    Abstract: The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels of the polynucleotides or polypeptides of the invention in a patient.
    Type: Application
    Filed: June 4, 2003
    Publication date: May 31, 2007
    Inventor: Bernard Allan
  • Methods of diagnosing & treating diabetes and insulin resistance
    Publication number: 20060292563
    Abstract: The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels of the polynucleotides or polypeptides of the invention in a patient.
    Type: Application
    Filed: June 5, 2003
    Publication date: December 28, 2006
    Applicant: Metabolex, Inc.
    Inventors: Bernard Allan, Brian Lavan, Shonna Moodie, Chi-Wai Wong
  • Methods of diagnosing and treating diabetes and insulin resistance
    Publication number: 20060234292
    Abstract: The present invention provides compositions and methods for diagnosing and treating diabetes and insulin resistance. In particular, the invention provides methods of identifying modulators of the polynucleotides or polypeptides of the invention and using those modulators to treat diabetes, as well as methods of diagnosing diabetes by measuring the levels of the polynucleotides or polypeptides of the invention in a patient.
    Type: Application
    Filed: June 5, 2003
    Publication date: October 19, 2006
    Inventors: Bernard Allan, Francine Gregoire, Brian Lavan, Shonna Moodie, Steve Waters, Chi-Wai Wong