Patents by Inventor Bernard Amegadzie

Bernard Amegadzie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Generation of human pIX phage display libraries
    Patent number: 9062305
    Abstract: Described and claimed herein are combinatorial synthetic Fab libraries displayed on a phage pIX protein. The libraries were built on scaffolds representing the most frequently used genes in human antibodies, which were diversified to mirror the variability of natural antibodies. After selection using a diverse panel of proteins, numerous specific and high-affinity Fabs were isolated. By a process called in-line maturation the affinity of some antibodies was improved up to one hundred-fold yielding low pM binders suitable for in vivo use. This work thus demonstrates the feasibility of displaying complex Fab libraries as pIX-fusion proteins for antibody discovery and lays the foundations for studies on the structure-function relationship of antibodies.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: June 23, 2015
    Assignee: Janssen Biotech, Inc.
    Inventors: Ping Tsui, Lei Shi, Jin Lu, John Wheeler, Brian Whitaker, Lionella Borozdina-Birch, Juan C. Almagro, Bernard Amegadzie, Mark Tornetta, Ramachandra Reddy, David M. Knight, Jinquan Luo, Raymond W. Sweet, Qiang Chen
  • BMP-7 variant compositions, methods and uses
    Patent number: 7659250
    Abstract: Human Bone Morphogenic Protein 7 (hBMP-7) variant peptide chains, nucleic acids encoding these peptide chains, and methods of making and using the foregoing are disclosed.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: February 9, 2010
    Assignee: Centocor, Inc.
    Inventors: Bernard Amegadzie, Mark Cunningham, Haimanti Dorai, Jeffrey Luo, Juliane Mills, Bethany Swencki-Underwood
  • DESIGN AND GENERATION OF HUMAN DE NOVO pIX PHAGE DISPLAY LIBRARIES
    Publication number: 20100021477
    Abstract: Described and claimed herein are combinatorial synthetic Fab libraries displayed on a phage pIX protein. The libraries were built on scaffolds representing the most frequently used genes in human antibodies, which were diversified to mirror the variability of natural antibodies. After selection using a diverse panel of proteins, numerous specific and high-affinity Fabs were isolated. By a process called in-line maturation the affinity of some antibodies was improved up to one hundred-fold yielding low pM binders suitable for in vivo use. This work thus demonstrates the feasibility of displaying complex Fab libraries as pIX-fusion proteins for antibody discovery and lays the foundations for studies on the structure-function relationship of antibodies.
    Type: Application
    Filed: August 25, 2009
    Publication date: January 28, 2010
    Inventors: Ping Tsui, Lei Shi, Jin Lu, John Wheeler, Brian Whitaker, Lionella Borozdina-Birch, Juan C. Almagro, Bernard Amegadzie, Mark Tornetta, Ramachandra Reddy, David M. Knight, Jinquan Luo, Raymond W. Sweet, Qiang Chen
  • Markers and Methods for Assessing and Treating Psoriasis and Related Disorders
    Publication number: 20090270480
    Abstract: A method for prognostic or diagnostic assessment of a skin-related disorder, such as psoriasis, in a subject correlates the presence, absence, and/or magnitude of a gene in a sample with a reference standard to determine the presence and/or severity of the disorder, and/or the response to treatment for the disorder. The method enables identification of the effectiveness of candidate therapies.
    Type: Application
    Filed: December 28, 2006
    Publication date: October 29, 2009
    Inventors: Bernard Amegadzie, Jacqueline Benson, Chong Huang, Xilin Li, Guihua Liu
  • BMP-7 Variant Compositions, Methods and Uses
    Publication number: 20080032919
    Abstract: Human Bone Morphogenic Protein 7 (hBMP-7) variant peptide chains, nucleic acids encoding these peptide chains, and methods of making and using the foregoing are disclosed.
    Type: Application
    Filed: June 8, 2007
    Publication date: February 7, 2008
    Inventors: Bernard Amegadzie, Mark Cunningham, Haimanti Dorai, Jeffrey Luo, Juliane Mills, Bethany Swencki-Underwood