Patents by Inventor Bernard Belleau

Bernard Belleau has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted-1, 3-oxathiolanes and substituted-1, 3-dioxolanes with antiviral properties
    Publication number: 20070037977
    Abstract: Disclosed are compounds of the formula wherein R1 is hydrogen or an acyl group having 1 to 16 carbon atoms; R2 is a purine or pyrimidine base or an analogue or derivative thereof; Z is O, S, S?O or SO2; and pharmaceutically acceptable derivatives thereof. Also, described are process for and intermediates of use in their preparation, pharmaceutical compositions containing these compounds, and the use of these compounds in the antiviral treatment of mammals.
    Type: Application
    Filed: August 11, 2006
    Publication date: February 15, 2007
    Inventors: Bernard Belleau, Pierette Belleau, Dilip Dixit, Nghe Nguyen-Ba
  • Substituted-1,3-oxathiolanes and substituted-1, 3-dioxolanes with antiviral properties
    Publication number: 20070037975
    Abstract: Disclosed are compounds of the formula wherein R1 is hydrogen or an acyl group having 1 to 16 carbon atoms; R2 is a purine or pyrimidine base or an analogue or derivative thereof; Z is O, S, S?O or SO2; and pharmaceutically acceptable derivatives thereof. Also described are processes for and intermediates of use in their preparation, pharmaceutical compositions containing these compounds, and the use of these compounds in the antiviral treatment of mammals.
    Type: Application
    Filed: October 16, 2006
    Publication date: February 15, 2007
    Inventors: Bernard Belleau, Dilip Dixit, Nghe Nguyen-Ba, Pierette Belleau
  • Acetaldehyde acetal compounds, their synthesis, and uses thereof
    Patent number: 7122693
    Abstract: The acetaldehyde compounds, 2-thiobenzoylacetaldehyde diethylacetal, 2-benzoyloxyacetaldehyde bis(2-methoxyethyl)acetal, 2-hydroxyacetaldehyde bis( 2-methoxyethyl)acetal, 2-thiobenzoylacetaldehyde bis(2-methoxy-ethyl)acetal, and 2-thioacetaldehyde bis(2-methoxyethyl)acetal, are useful as intermediates in the synthesis of substituted 1,3-oxathiolanes and substituted 1,3-dioxolanes.
    Type: Grant
    Filed: July 9, 2004
    Date of Patent: October 17, 2006
    Assignee: Shire BioChem Inc.
    Inventors: Pierette Belleau, executrix of estate, Dilip M. Dixit, Nghe Nguyen-Ba, Bernard Belleau, deceased
  • Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties
    Patent number: 7119202
    Abstract: Disclosed are compounds of the formula wherein R1 is hydrogen or an acyl group having 1 to 16 carbon atoms; R2 is a purine or pyrimidine base or an analogue or derivative thereof; Z is O, S, S?O or SO2; and pharmaceutically acceptable derivatives thereof. Also described are processes for and intermediates of use in their preparation, pharmaceutical compositions containing these compounds, and the use of these compounds in the antiviral treatment of mammals.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 10, 2006
    Assignee: Glaxo Wellcome Inc.
    Inventors: Pierrette Belleau, legal representative, Paul Nguyen Ba, Bernard Belleau, deceased
  • Substituted 1,3-oxathiolanes
    Patent number: 6903224
    Abstract: Substituted 1,3-oxathiolanes, such as cis- and trans-2-ethoxycarbonyl-5-hydroxy-1,3-oxathiolane and cis- and trans-2-ethoxycarbonyl-5-acetoxy-1,3-oxathiolane, are suitable as intermediates for the production of substituted 1,3-oxathiolanes nucleoside analogs having antiviral properties.
    Type: Grant
    Filed: February 12, 2002
    Date of Patent: June 7, 2005
    Assignee: BioChem Pharma Inc.
    Inventors: Pierette Belleau, Dilip M. Dixit, Nghe Nguyen-Ba, Bernard Belleau
  • Substituted-1,3-oxathiolanes and substituted-1,3-dioxolanes with antiviral properties
    Publication number: 20040254201
    Abstract: Disclosed are compounds of the formula
    Type: Application
    Filed: July 9, 2004
    Publication date: December 16, 2004
    Inventors: Bernard Belleau, Pierette Belleau, Dilip M. Dixit, Nghe Nguyen-Ba
  • Processes for preparing substituted 1, 3-oxathiolanes with antiviral properties
    Patent number: 6831174
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S═O or SO2. The invention also relates to intermediates of use in the preparation of these compounds.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: December 14, 2004
    Assignee: Shire BioChem Inc.
    Inventors: Bernard Belleau, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
  • Synthesis of substituted 1,3-dioxolanes and substituted 1,3-oxathiolanes with antiviral properties
    Publication number: 20030087918
    Abstract: Disclosed are compounds of the formula
    Type: Application
    Filed: February 12, 2002
    Publication date: May 8, 2003
    Applicant: BioChem Pharma Inc.
    Inventors: Bernard Belleau, Pierette Belleau, Dilip Dixit, Nghe Nguyen-Ba
  • 2-Substituted-4-substituted-1,3-dioxolanes and use thereof
    Patent number: 6350753
    Abstract: Nucleoside analogues containing a 1,3-dioxolane structure are suitable antiviral agents, particulary for the treatment of the HIV infections in mammals, especially humans. Examples of the nucleoside analogues include: cis-2-acetoxymethyl-4-(thymin-1′-yl)-1,3,-dioxolane, cis-2-hydroxymethyl-4-(thymin-1′-yl)-1,3-dioxolane, cis-2-benzoyloxymethyl-4-(cytosin-1′-yl)-1,3-dioxolane, and cis-2-hydroxymethyl-4-(cytosin-1′-yl)-1,3-dioxolane. These compounds can be in the form of their racemates or their separate enantiomers.
    Type: Grant
    Filed: September 30, 1998
    Date of Patent: February 26, 2002
    Assignee: Biochem Pharma Inc.
    Inventors: Bernard Belleau, Dilip M. Dixit, Paul Nguyen-Ba
  • Processes for preparing substituted 1, 3-oxathiolanes with antiviral properties
    Publication number: 20010041797
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: 1
    Type: Application
    Filed: January 16, 2001
    Publication date: November 15, 2001
    Applicant: BioChem Pharma Inc.
    Inventors: Bernard Belleau, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
  • SUBSTITUTED-1,3-OXATHIOLANES AND SUBSTITUTED-1,3-DIOXOLANES WITH ANTIVIRAL PROPERTIES
    Publication number: 20010020026
    Abstract: Disclosed are compounds of the formula
    Type: Application
    Filed: October 15, 1998
    Publication date: September 6, 2001
    Inventors: BERNARD BELLEAU, PIERETTE BELLEAU, NGHE NGUYEN-BA
  • Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
    Patent number: 6175008
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S═O or SO2. The invention also relates to intermediates of use in the preparation of these compounds.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 16, 2001
    Assignee: BioChem Pharma Inc.
    Inventors: Bernard Belleau, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
  • Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
    Patent number: 5684164
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: ##STR1## wherein R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S.dbd.O or SO.sub.2. The invention also relates to intermediates of use in the preparation of these compounds.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 4, 1997
    Assignee: BioChem Pharma Inc.
    Inventors: Bernard Belleau, deceased, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
  • Heterocyclic anthracycline analogs
    Patent number: 5593970
    Abstract: Novel pyrano heterocyclic anthracycline derivatives are described, which are useful in the treatment of cancer and tumors, such as breast cancer, leukemia, lung cancer, colon cancer, ovarian cancer, renal cancer, and melanoma. As well, these compounds may be used ex vivo for the treatment of cancerous bone marrow before retransplanting said marrow in a patient. Pharmaceutical compositions and methods of preparing the compounds are also described.
    Type: Grant
    Filed: June 20, 1994
    Date of Patent: January 14, 1997
    Assignee: Biochem Pharma Inc.
    Inventors: Giorgio Attardo, Jean-Louis Kraus, Marc Courchesne, Serge Lamonthe, Jean-Fran.cedilla.ois Lavall ee, Elaine Lebeau, Dieu Nguyen, Rabindra Rej, Yves St-Denis, Wuyi Wang, Yao-Chang Xu, France Barbeau, Bernard Belleau, deceased
  • Substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes with antiviral properties
    Patent number: 5587480
    Abstract: This invention relates to novel substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes or pharmaceutically acceptable salts and esters thereof, of the formula: ##STR1## wherein X is S, S.dbd.O, or SO.sub.2 ;Y is O, S, S.dbd.O, or SO.sub.2 ;R.sub.1 is hydrogen, trisubstituted silyl, C.sub.1-6 alkyl, aralkyl, or C.sub.1-6 acyl, and R.sub.2 is a pyrimidine base or an analogue or derivative thereof.This invention also relates to processes for preparing these compounds, intermediates useful in their preparation, to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents.
    Type: Grant
    Filed: April 20, 1994
    Date of Patent: December 24, 1996
    Assignee: BioChem Pharma, Inc.
    Inventors: Bernard Belleau, deceased, Nghe Nguyen-Ba, Laval C. C. Kong, Tarek Mansour, Haolun Jin, Livio Brasili
  • Use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis B
    Patent number: 5532246
    Abstract: Use of a compound of formula (I) or a pharmaceutically acceptable derivative thereof in the manufacture of a medicament for the treatment of hepatitis B is disclosed.
    Type: Grant
    Filed: August 9, 1993
    Date of Patent: July 2, 1996
    Assignee: BioChem Pharma, Inc.
    Inventors: Bernard Belleau, deceased, Nghe Nguyen-Ba
  • 1,3-oxathiolanes useful in the treatment of hepatitis
    Patent number: 5486520
    Abstract: The present invention relates to the use of nucleoside analogues in the treatment of viral infections. More specifically it is concerned with the use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis, in particular hepatitis B.
    Type: Grant
    Filed: December 10, 1993
    Date of Patent: January 23, 1996
    Assignee: BioChemPharma, Inc.
    Inventors: Bernard Belleau, deceased, Nghe Nguyen-Ba
  • Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
    Patent number: 5466806
    Abstract: Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: ##STR1## wherein R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S.dbd.O or SO.sub.2. The invention also relates to intermediates of use in the preparation of these compounds.
    Type: Grant
    Filed: March 29, 1993
    Date of Patent: November 14, 1995
    Assignee: Biochem Pharma Inc.
    Inventors: Bernard Belleau, deceased, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
  • 1-amino thiorcyl benzimidazoyl-2-one compounds
    Patent number: 5371185
    Abstract: This invention relates to 1-amino thioacylbenzimidazoyl-2-one derivatives having the formula: ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are defined herein. These compounds are useful as thioacylating reagents. This invention also relates to a process for producing cyclic and linear thiopeptides using the thioacylating reagents of this invention. This invention further relates to intermediate anilide compounds, which are produced by reacting an ortho phenylene diamine with an amino acid chain or peptide. This invention also relates to intermediate thioanilide compounds, which are produced by thionating the intermediate anilide compounds. This invention further relates to a process for producing the thioacylating reagents of this invention by cyclizing the intermediate thioanilide compounds.
    Type: Grant
    Filed: February 21, 1992
    Date of Patent: December 6, 1994
    Assignee: Biochem Pharma Inc.
    Inventors: Bernard Belleau, Denis Brillon, Gilles Sauve, Boulos Zacharie
  • Use of 1,3-oxathiolane nucleoside analogues in the treatment of hepatitis B
    Patent number: RE39155
    Abstract: Use of a compound of formula (I) or a pharmaceutically acceptable derivative thereof in the manufacture of a medicament for the treatment of hepatitis B is disclosed.
    Type: Grant
    Filed: January 3, 1992
    Date of Patent: July 4, 2006
    Assignee: Shire BioChem Inc.
    Inventors: Pierrette Belleau, Nghe Nguyen-Ba, Bernard Belleau