Patents by Inventor Bernard Bonnaud

Bernard Bonnaud has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8188126
    Abstract: The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: May 29, 2012
    Assignee: Pierre Fabre Medicament
    Inventors: Bernard Vacher, Bernard Bonnaud, Marc Marien, Peter Pauwels
  • Publication number: 20110021589
    Abstract: The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.
    Type: Application
    Filed: May 24, 2010
    Publication date: January 27, 2011
    Applicant: PIERRE FABRE MEDICAMENT
    Inventors: Bernard Vacher, Bernard Bonnaud, Marc Marien, Peter Pauwels
  • Patent number: 7776901
    Abstract: The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: August 17, 2010
    Assignee: Pierre Fabre Medicament
    Inventors: Bernard Vacher, Bernard Bonnaud, Marc Marien, Peter Pauwels
  • Patent number: 7651108
    Abstract: Drive wheel (6) is designed to pivot around a first axis (X-X?), which in particular is horizontal, for the purpose of advance of the vehicle, and around a second axis (Y-Y?), which in particular is vertical, for the purpose of steering of the vehicle, while fairing (8) extends laterally to the vicinity of wheel (6) when the vehicle is in operation, so that it at least partly covers an outer side of said wheel. Fairing (8) is not linked in rotation to wheel (6) around the first axis, with the result that it is not constrained to rotate around said axis during the advance of the vehicle, whereas said fairing is linked in rotation to said wheel around the second axis, so that it follows the steering movements of said wheel.
    Type: Grant
    Filed: October 24, 2005
    Date of Patent: January 26, 2010
    Assignee: Irisbus France S.A.
    Inventors: Bernard Bonnaud, Bruno Cornuault
  • Patent number: 7547700
    Abstract: The invention relates to compounds of general formula (1) in which X and Y=a carbon with a bonded hydrogen atom (CH) or a nitrogen atom, A=a methyl, fluoromethyl, cyano, hydroxyl, methoxy group, or a chlorine or fluorine atom on condition that when A=methyl (CH3) and X and Y both=a carbon bonded to a hydrogen atom, then B=a chlorine atom, B=a chlorine or a fluorine atom, D=a hydrogen, chlorine, fluorine atom, or a cyano or trifluoromethyl group and E=a hydrogen, fluorine or chlorine atom.
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: June 16, 2009
    Assignee: PIERRE Fabre Medicament
    Inventors: Bernard Vacher, Bernard Bonnaud, Jean-Louis Maurel, Francis Colpaert
  • Patent number: 7458595
    Abstract: This fairing comprises a cowl (14) and means (26, 42) for connecting said fairing to the vehicle body (16),said connecting means are designed to allow the release of the fairing from the vehicle body, according to a release movement, when said fairing is subjected to a force exceeding a preset value, in particular when the tyre of said wheel bursts, and said fairing also includes means that enable it to be retained to vehicle body (16) during said release movement, to prevent said fairing from forming projectile material.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: December 2, 2008
    Assignee: Irisbus France S.A.
    Inventors: Bernard Bonnaud, Bruno Cornuault
  • Publication number: 20070197793
    Abstract: The invention provides methods of treating a memory deficiency in a subject in need of such treatment, where the methods comprise administering to a subject an effective amount of a compound of formula (1): wherein: R1 is hydrogen, fluorine or a methoxyl group, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or a methyl group; R3 is hydrogen, a methyl group or an ethyl group; and their pharmaceutically acceptable acid addition salt as well as the isomers and the tautomers thereof. The memory deficiency may be correlated with a memory deficiency induced by scopolamine.
    Type: Application
    Filed: April 5, 2007
    Publication date: August 23, 2007
    Applicant: PIERRE FABRE MEDICAMENT
    Inventors: Bernard Vacher, Bernard Bonnaud, Marc Marien, Peter Pauwels
  • Patent number: 7220866
    Abstract: The invention provides compounds having the formula (1): wherein R1 is hydrogen, fluoro or methoxyl, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or methyl; R3 is hydrogen, methyl or ethyl; and their pharmaceutically acceptable acid addition salts, hydrates of their pharmaceutically acceptable acid addition salts as well as the isomers and the tautomers thereof.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: May 22, 2007
    Assignee: Pierre Fabre Medicament
    Inventors: Bernard Vacher, Bernard Bonnaud, Marc Marien, Peter Pauwels
  • Patent number: 7208603
    Abstract: The invention concerns a novel method for preparing pyridin-2-yl-methylamine derivatives by reducing amination of cyanohydrins.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: April 24, 2007
    Assignee: Pierre Fabre Medicament
    Inventors: Jean-Louis Maurel, Bernard Bonnaud, Jean-Paul Ribet, Bernard Vacher
  • Publication number: 20060157952
    Abstract: This fairing comprises a cowl (14) and means (26, 42) for connecting said fairing to the vehicle body (16),said connecting means are designed to allow the release of the fairing from the vehicle body, according to a release movement, when said fairing is subjected to a force exceeding a preset value, in particular when the tyre of said wheel bursts, and said fairing also includes means that enable it to be retained to vehicle body (16) during said release movement, to prevent said fairing from forming projectile material.
    Type: Application
    Filed: January 6, 2006
    Publication date: July 20, 2006
    Inventors: Bernard Bonnaud, Bruno Cornuault
  • Publication number: 20060131087
    Abstract: Drive wheel (6) is designed to pivot around a first axis (X-X?), which in particular is horizontal, for the purpose of advance of the vehicle, and around a second axis (Y-Y?), which in particular is vertical, for the purpose of steering of the vehicle, while fairing (8) extends laterally to the vicinity of wheel (6) when the vehicle is in operation, so that it at least partly covers an outer side of said wheel. Fairing (8) is not linked in rotation to wheel (6) around the first axis, with the result that it is not constrained to rotate around said axis during the advance of the vehicle, whereas said fairing is linked in rotation to said wheel around the second axis, so that it follows the steering movements of said wheel.
    Type: Application
    Filed: October 24, 2005
    Publication date: June 22, 2006
    Inventors: Bernard Bonnaud, Bruno Cornuault
  • Publication number: 20060100244
    Abstract: The invention relates to compounds of general formula (1) in which X and Y=a carbon with a bonded hydrogen atom (CH) or a nitrogen atom, A=a methyl, fluoromethyl, cyano, hydroxyl, methoxy group, or a chlorine or fluorine atom on condition that when A=methyl (CH3) and X and Y both=a carbon bonded to a hydrogen atom, then B=a chlorine atom, B=a chlorine or a fluorine atom, D=a hydrogen, chlorine, fluorine atom, or a cyano or trifluoromethyl group and E=a hydrogen, fluorine or chlorine atom.
    Type: Application
    Filed: June 18, 2003
    Publication date: May 11, 2006
    Inventors: Bernard Vacher, Bernard Bonnaud, Jean-Louis Maurel, Francis Colpaert
  • Publication number: 20060041001
    Abstract: The invention provides compounds having the formula (1): wherein R1 is hydrogen, fluoro or methoxyl, R1 being in position 2, 3, 4 or 5 of the aromatic carbocycle; R2 is hydrogen or methyl; R3 is hydrogen, methyl or ethyl; and their pharmaceutically acceptable acid addition salts, hydrates of their pharmaceutically acceptable acid addition salts as well as the isomers and the tautomers thereof.
    Type: Application
    Filed: May 15, 2003
    Publication date: February 23, 2006
    Applicant: Pierre Fabre Medicament
    Inventors: Bernard Vacher, Bernard Bonnaud, Marc Marien, Peter Pauwels
  • Publication number: 20050107455
    Abstract: The invention relates to compounds of general formula (1) in which R1=H, F or OCH3 and may occupy the 2, 3, 4 or 5 position on the aromatic carbocycle, R2=H or CH3, R3=H, CH3, OH or OCH3, R4=H and R3 and R4 together can be a carbonyl group (C=0), the addition salts and optionally the hydrates of additional salts with pharmaceutically-acceptable mineral or organic acids and the isomers and tautomers thereof.
    Type: Application
    Filed: February 14, 2003
    Publication date: May 19, 2005
    Inventors: Bernard Vacher, Bernard Bonnaud, Marc Marien, Thierry Imbert
  • Publication number: 20040116705
    Abstract: The invention concerns a novel method for preparing pyridin-2-yl-methylamine derivatives by reducing amination of cyanohydrins.
    Type: Application
    Filed: January 27, 2004
    Publication date: June 17, 2004
    Inventors: Jean-Louis Maurel, Bernard Bonnaud, Jean-Paul Ribet, Bernard Vacher
  • Patent number: 6448268
    Abstract: The invention concerns novel ary1-{4-fluoro-4-[(2-pyridin-2-yl-ethylamino)-methyl]-piperidin-1-yl}-methanone derivatives of formula(1) wherein X is a hydrogen, fluorine or chlorine atom useful as medicines in particular having antidepressant, analgesic, anxiolytic and neuroprotective effects.
    Type: Grant
    Filed: May 29, 2001
    Date of Patent: September 10, 2002
    Assignee: Pierre Fabre Medicament
    Inventors: Bernard Vacher, Bernard Bonnaud, Wouter Koek
  • Patent number: 6433060
    Abstract: The present invention relates to a process for seeded microsuspension polymerization of vinyl chloride in aqueous medium under the action of at least one organosoluble initiator, at least one reducing agent and at least one water-soluble metal salt in the presence of at least one fatty acid alkali metal or ammonium salt. It also relates to the polymers obtained in this way which are suitable for giving plastisols having specific properties.
    Type: Grant
    Filed: December 29, 1999
    Date of Patent: August 13, 2002
    Assignee: Atofina
    Inventors: Christian Bonardi, Bernard Bonnaud, André Chippaux, Richard Peres
  • Patent number: 6020345
    Abstract: The invention concerns novel pyridin-2-yl-methylamine derivatives of formula (I): ##STR1## in which: u represents hydrogen or methyl;v represents hydrogen, chlorine, or methyl;w represents hydrogen, fluorine, or methyl;x represents hydrogen or fluorine;y represents chlorine or methyl;z represents hydrogen, fluorine, chlorine, or methyl;A represents hydrogen, fluorine, chlorine, C.sub.1 -C.sub.5 alkyl, fluoroalkyl, cyclopropyl, a 5-membered aromatic heterocyclic group, alkoxy or alkythio, amino, cyclic amino, or alkoxycarbonyl. These compounds are useful as medicines, in particular as antidepressants or analgesics.
    Type: Grant
    Filed: May 21, 1999
    Date of Patent: February 1, 2000
    Assignee: Pierre Fabre Medicament
    Inventors: Bernard Vacher, Bernard Bonnaud, Wouter Koek
  • Patent number: 5286735
    Abstract: The application discloses pharmacologically-active derivatives of 4-aminomethyl piperidine having the general formula 1 ##STR1## wherein the symbols have the meanings set forth in the Specification, as well as pharmaceutically-acceptable acid addition salts thereof, the use of the compounds as serotoninergic receptor ligands and for the treatment of anxiety, depression, and other related serotoninergic system disorders, pharmaceutical compositions thereof, and a method for their preparation.
    Type: Grant
    Filed: September 14, 1992
    Date of Patent: February 15, 1994
    Assignee: Pierre Fabre Medicament
    Inventors: Bernard Bonnaud, Dennis Bigg
  • Patent number: 4567288
    Abstract: The present invention concerns new derivatives of 1-aryl 2-aminomethyl cyclopropane carboxylates (Z), their preparation and their use as useful drugs for the treatment of various pains.The new derivatives of the present invention have the general formula I ##STR1## in which: R represents a hydrogen or halogen atom, a C.sub.1 to C.sub.4 lower alkyl group, a C.sub.1 to C.sub.4 lower alkoxy group, or a nitro, amino, sulfamoyl or hydroxy group;n represents the values 1, 2 or 3;(R).sub.n may together with the benzene ring also form the naphthyl group;R.sub.1 represents a linear or branched C.sub.1 to C.sub.5 alkyl or alkenyl group or an aryl or benzyl group;R.sub.2 and R.sub.3 represent a hydrogen atom, a linear or branched C.sub.1 to C.sub.5 alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl or dialkylaminoalkyl group or an aryl, arylalkyl or cycloalkyl group;R.sub.2 and R.sub.3 possibly also forming a heterocycle of 5 or 6 members with the adjacent nitrogen atom,provided however that when R.sub.
    Type: Grant
    Filed: October 1, 1984
    Date of Patent: January 28, 1986
    Assignee: Pierre Fabre S.A.
    Inventors: Henri Cousse, Gilbert Mouzin, Bernard Bonnaud, Marie Charveron, Francois Fauran