Patents by Inventor Bernard Brais

Bernard Brais has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Short GCG expansions in the PAB II gene for oculopharyngeal muscular dystrophy and diagnostic thereof
    Patent number: 7364852
    Abstract: The present invention relates to a human PAB II gene containing transcribed polymorphic GCG repeat, which comprises a sequence as set forth in SEQ ID NO:3, which includes introns and flanking genomic sequence. The allelic variants of GCG repeat of the human PAB II gene are associated with a disease related with protein accumulation in nucleus, such as polyalanine accumulation, a disease related with swallowing difficulties, such as oculopharyngeal muscular dystrophy. The present invention also relates to a method for the diagnosis of a disease with protein accumulation in nucleus, which comprises the steps of: a) obtaining a nucleic acid sample of said patient; and b) determining allelic variants of GCG repeat of the gene of claim 1, and wherein long allelic variants are indicative of a disease related with protein accumulation in nucleus.
    Type: Grant
    Filed: July 12, 2004
    Date of Patent: April 29, 2008
    Assignee: McGill University
    Inventors: Guy A. Rouleau, Bernard Brais
  • Short GCG expansions in the PABII gene for oculopharyngeal muscular dystrophy and diagnostic thereof
    Publication number: 20050069922
    Abstract: The present invention relates to a human PAB II gene containing transcribed polymorphic GCG repeat, which comprises a sequence as set forth in SEQ ID NO:3, which includes introns and flanking genomic sequence. The allelic variants of GCG repeat of the human PAB II gene are associated with a disease related with protein accumulation in nucleus, such as polyalanine accumulation, a disease related with swallowing difficulties, such as oculopharyngeal muscular dystrophy. The present invention also relates to a method for the diagnosis of a disease with protein accumulation in nucleus, which comprises the steps of: a) obtaining a nucleic acid sample of said patient; and b) determining allelic variants of GCG repeat of the gene of claim 1, and wherein long allelic variants are indicative of a disease related with protein accumulation in nucleus.
    Type: Application
    Filed: July 12, 2004
    Publication date: March 31, 2005
    Applicant: McGill University
    Inventors: Guy Rouleau, Bernard Brais
  • Short GCG expansions in the PAB II gene for oculopharyngeal muscular dystrophy and diagnostic thereof
    Patent number: 6828430
    Abstract: The present invention relates to a human PAB II gene containing transcribed polymorphic GCG repeat, which comprises a sequence as set forth in SEQ ID NO:18, which includes introns and flanking genomic sequence. Allelic variants of GCG repeat of the human PAB II gene are associated with a disease related with protein accumulation in the nucleus, such as polyalanine accumulation, or with swallowing difficulties, such as oculopharyngeal muscular dystrophy. The present invention also relates to a method for the diagnosis of a disease associated with protein accumulation in the nucleus, which comprises the steps of: a) obtaining a nucleic acid sample of a patient; and b) determining allelic variants of GCG repeat of the PAB II gene, and wherein long allelic variants are indicative of a disease related with protein accumulation in the nucleus.
    Type: Grant
    Filed: June 8, 2000
    Date of Patent: December 7, 2004
    Assignee: McGill University
    Inventors: Guy A. Rouleau, Bernard Brais