Abstract: Formulations for pitch control, and methods of making and using thereof, are described herein. The formulations contains one or more 1,3-selective lipases. 1,3-selective lipases catalyze the hydrolysis of the terminal ester groups in triglycerides leaving the internal ester group intact. The enzyme formulations can contain one or more additives, such as dispersants, metal ions, absorbents, adsorbents, cationic polymers, and combinations thereof. The enzyme formulation is typically applied as a solution to the pulp stock. The enzyme formulations can be applied at any of one or more various points during the pulping and paper manufacturing processes. The use of selective lipase(s) decreases the total concentration of fatty acids in the system, and catalyzes the formation of monoglycerides, which are more effective at dispersing fatty acids than glycerol, the product of non-selective lipases, thereby improving pulp and paper machine runnability and pulp and paper quality.