Patents by Inventor Bernard C. Sherman

Bernard C. Sherman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical acceptable compositions containing an alcohol and a hydrophobic drug
    Patent number: 5843891
    Abstract: Pharmaceutical compositions having improved physical and absorption properties are disclosed, wherein a hydrophobic drug is dissolved in a solvent system comprising at least one alcohol having a boiling point above 100.degree. C. and a solubility in water inferior to 10 g per 100 g at 20.degree. C. and a surfactant.
    Type: Grant
    Filed: October 27, 1995
    Date of Patent: December 1, 1998
    Inventor: Bernard C. Sherman
  • Water-soluble concentrates containing cyclosporins
    Patent number: 5798333
    Abstract: The invention is directed to pharmaceutical compositions which enable high concentrations of a cyclosporin and are water-soluble, such that the compositions will dissolve in aqueous media without precipitation of the cyclosporin. The compositions comprise a cyclosporin dissolved in tocophersolan and a hydrophillic organic solvent, preferably propylene glycol.
    Type: Grant
    Filed: September 17, 1996
    Date of Patent: August 25, 1998
    Inventor: Bernard C. Sherman
  • Controlled release formulation of diltiazem hydrochloride
    Patent number: 5578321
    Abstract: A pharmaceutical tablet containing diltiazem hydrochloride suitable for once daily oral administration comprising by weight not less than 30 percent diltiazem hydrochloride and from 30 percent to 70 percent hydroxypropyl methylcellulose having a number average molecular weight of at least 50,000. A two piece hard gelatin capsule containing a plurality of such tablets.
    Type: Grant
    Filed: May 11, 1995
    Date of Patent: November 26, 1996
    Inventor: Bernard C. Sherman
  • Stable solid formulation of enalapril salt and process for preparation thereof
    Patent number: 5573780
    Abstract: There is disclosed a stable pharmaceutical solid composition comprising enalapril as the sodium salt, which is made by the steps of:i) mixing enalapril maleate with a carrier, an alkaline sodium compound, and waterii) drying the wet mass, and;iii) further processing the resultant dried mass into tablets.When the water is added in the aforesaid process, an acid-base reaction occurs which converts the enalapril maleate into the more stable enalapril sodium salt.
    Type: Grant
    Filed: August 4, 1995
    Date of Patent: November 12, 1996
    Assignee: Apotex USA Inc.
    Inventor: Bernard C. Sherman
  • Stable solid pharmaceutical compositions containing enalapril maleate
    Patent number: 5562921
    Abstract: Enalapril maleate is unstable when associated with many excipients commonly used in the manufacture of pharmaceutical compositions. Stable solid compositions are provided by mixing enalapril maleate into a carrier that is comprised primarily of water-soluble carbohydrates and contains a lubricant other than magnesium stearate, a preferred lubricant being zinc stearate.
    Type: Grant
    Filed: July 15, 1994
    Date of Patent: October 8, 1996
    Inventor: Bernard C. Sherman
  • Pharmaceutical composition of ticlopidine hydrochloride
    Patent number: 5520928
    Abstract: A pharmaceutical composition which comprises ticlopidine hydrochloride together with stearic acid and other suitable pharmaceutical excipients, and which does not contain any organic acid other than stearic acid.
    Type: Grant
    Filed: September 28, 1993
    Date of Patent: May 28, 1996
    Inventor: Bernard C. Sherman