Abstract: Among other things, the present disclosure provides oligonucleotides targeting SARM1 and compositions thereof. In some embodiments, the present disclosure provides methods for preventing or treating various conditions, disorders or diseases.

Abstract: Among other things, the present disclosure provides oligonucleotides targeting calpain-2 and compositions thereof. In some embodiments, the present disclosure provides methods for preventing or treating various conditions, disorders or diseases.

Abstract: A beverage container is formed of a stacked array of interlocking single-serving container segments which allows indefinite storage of the container segments and which facilitates access to the beverage contained within a selected container segment without compromising the remaining quantities of the beverage

Abstract: The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1? in neurons. The invention also provides HSV vectors for expressing PP1? within neurons and compositions comprising such vectors.

Abstract: Resistance to the induction of a vasovagal response can be imparted in an animal by inducing galvanic vestibular stimulation of the animal and repeating the galvanic vestibular stimulation such that the animal is habituated to resist the induction of the vasovagal response.

Abstract: The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1? in neurons. The invention also provides HSV vectors for expressing PP1? within neurons and compositions comprising such vectors.

Abstract: The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1? in neurons. The invention also provides HSV vectors for expressing PP1? within neurons and compositions comprising such vectors.

Abstract: A water bottle lifting and rotating device includes a base supporting a pair of rolling wheels and forwardly extending supports. The base further supports a vertically extending mast upon which a bottle clasp is lifted and lowered by a cable arrangement. A drive motor also supported on the base is operative in combination with the pulley and cable arrangement to raise and lower the bottle clasp and thereby raise and lower a captive water bottle. The bottle clasp supporting a water bottle is automatically rotated to an inverted position by a gear and gear rack arrangement operative between the mast and the bottle clasp.

Abstract: A water bottle lifting and rotating device includes a base supporting a pair of rolling wheels and forwardly extending supports. The base further supports a vertically extending mast upon which a bottle clasp is lifted and lowered by a cable arrangement. A drive motor also supported on the base is operative in combination with the pulley and cable arrangement to raise and lower the bottle clasp and thereby raise and lower a captive water bottle. The bottle clasp supporting a water bottle is automatically rotated to an inverted position by a gear and gear rack arrangement operative between the mast and the bottle clasp.

Abstract: A tailgating game assembly including a first platform, a second platform, a projectile a first deformable target, a second deformable target, a third deformable target, and a club. In use, the club is used to hit the projectile off of the platform towards the three deformable targets. The game is meant to simulate the chipping aspect of golf. The club included in the assembly is capable of height adjustment, and is suitable for both right and left handed competitors. The projectile included may be a golf ball, a shuttlecock, or any projectile suitable to strike with a club.

Abstract: The invention provides a method of selecting a nebulizer device to be used to deliver a vaccine comprising selecting a nebulizer capable of producing a plurality of vaccine particles having the following particle droplet size distribution: (i) Dv10: 2.0+/?0.2 ?m (ii) Dv50: 5.0+/?0.5 ?m (iii) Dv90: 10.0+/?1.0 ?m (iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 ?m This allows the selection of, for example, commercially available nebulizers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulizers. Nebulizers identified by the methods of the invention are also claimed.

Abstract: The invention provides a method of selecting a nebuliser device to be used to deliver a vaccine comprising selecting a nebuliser capable of producing a plurality of vaccine particles having the following particle droplet size distribution: (i) Dv10: 2.0+/?0.2 ?m (ii) Dv50: 5.0+/?0.5 ?m (iii) Dv90: 10.0+/?1.0 ?m (iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 ?m This allows the selection of, for example, commercially available nebulisers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulisers. Nebulisers identified by the methods of the invention are also claimed.

Abstract: The invention provides a method of selecting or optimising a nebuliser device to be used to deliver a vaccine comprising selecting a nebuliser capable of producing a plurality of vaccine particles having the following particle droplet size distribution: (i) Dv10: 2.0+/?0.2 ?m (ii) Dv50: 5.0+/?0.5 ?m (iii) Dv90: 10.0+/?1.0 ?m (iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 ?m This allows the selection of, for example, commercially available nebulisers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulisers. The additional preferred features are disclosed for the selection of nebulisers for use in mass vaccination programs. Nebulisers identified by the methods of the invention are also claimed.

Abstract: A process for the destruction of microorganisms on a product using ultrasonic energy is disclosed. The process comprises contacting a product with an ultrasonic horn assembly and generating ultrasonic energy sufficient to result in a microorganism destruction rate of at least a 1-log kill.

Abstract: A process for the destruction of microorganisms on a product using ultrasonic energy is disclosed. The process comprises contacting a product with an ultrasonic horn assembly and generating ultrasonic energy sufficient to result in a microorganism destruction rate of at least a 1-log kill.

Abstract: The method for isolating an area of hair-bearing skin and measuring a combined cross section of hair in the area comprising the steps of: preparing a pre-measured site on the scalp; isolating a standardized bundle of uncut hair at the site; compressing the bundle of hair with a measurable load while simultaneously measuring the height of the bundle of hair with a piston and cylinder device. One embodiment of the device comprises a body having a slot for receiving a bundle of hair, an anvil positioned adjacent said slot, and a mechanism for causing relative movement between the body having the slot and the anvil thereby to compress a bundle of uncut hair received in the slot against the anvil.

Abstract: A flexible measuring tape is extended from a predetermined location on a face a predetermined distance to a location on a scalp. A 2 cm by 2 cm square bundle of hair about that location is isolated. The bundle of isolated hair is captured in a slit in a two-part cartridge, one part being slidable in the other part about a changeable length slit 1 mm wide. The cartridge is placed in an “L” shaped end of a plunger extending from a first end of a body of a measuring device. The plunger is drawn into the body of the device to compress the hair in the changeable length slit as the two parts of the cartridge are pushed together between an end of the “L” and the first end of the body. A spring is provided on the plunger between a second end of the body of the device and an inner end of a knob at an outer end of the plunger.

Abstract: A biodegradable, cellulose-based collecting sheet that can be used in either a wet state or a dry state. The collecting sheet may be a double recreped cellulose substrate reinforced with a binder, such as a latex binder. Alternatively, or in addition to the binder, the collecting sheet may be coated with a dielectric material and electret treated to establish a charge on the dielectric material. Additionally, the collecting sheet may be embossed to provide more interstices and greater surface area to enhance the pick-up ability of the collecting sheet. The invention further includes a method of forming such a collecting sheet.

Abstract: A method involves retrofitting conventional injectors with needles having magnetostrictive portions and wound coils configured and disposed so as to subject the magnetostrictive portions of the needles to ultrasonically oscillating magnetic fields.

Abstract: The present invention relates to a composite material including a substrate with a first and a second layer, and a surfactant. The surfactant is applied to the first layer of the substrate. The surfactant acts to lower the surface tension of a fluid which contacts the first layer of the substrate such that the fluid is allowed or more readily enabled to pass through the first layer of the substrate, but such that the surfactant does not substantially adversely effect the absorption capacity or wicking height of the second layer of the substrate, as the second layer of the substrate substantially inactivates the surfactant upon contact or interaction therewith.