Patents by Inventor Bernard D. Johnson

Bernard D. Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-cyanoquinolines as inhibitors of EGF-R and HER2 kinases
    Patent number: 6821988
    Abstract: This invention provides compounds of Formula (I), represented by the structure wherein G1, G2, G3, G4, Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which are useful as antineoplastic agents and in the treatment of polycystic kidney disease.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: November 23, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Allan Wissner, Hwei-Ru Tsou, Middleton Brawner Floyd, Jr., Bernard D. Johnson, Elsebe Geraldine Overbeek-Klumpers
  • 3-cyanoquinolines as inhibitors of EGF-R and HER2 kinases
    Publication number: 20030149056
    Abstract: This invention provides compounds of Formula (I), represented by the structure 1
    Type: Application
    Filed: November 26, 2002
    Publication date: August 7, 2003
    Applicant: American Cyanamid Company
    Inventors: Allan Wissner, Hwei-Ru Tsou, Middleton Brawner Floyd, Bernard D. Johnson, Elsebe Geraldine Overbeek-Klumpers
  • Substituted quinazoline derivatives
    Patent number: 6251912
    Abstract: This invention provides compounds of formula 1 having the structure wherein: X, R1, R2, R3, R4, Z, X, and n are as defined hereinbefore in the specification, which are useful as antineoplastic agents and in the treatment of certain kidney diseases, such as polycystic kidney disease.
    Type: Grant
    Filed: July 29, 1998
    Date of Patent: June 26, 2001
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Hwei-Ru Tsou, Bernard D. Johnson, Philip R. Hamann, Nan Zhang
  • Substituted 3-cyano quinolines
    Patent number: 6002008
    Abstract: This invention provides compounds having the formula: ##STR1## wherein: X is cycloalkyl which may be optionally substituted; or is a pyridinyl, pyrimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally substituted;n is 0-1;Y is --NH--, --O--, --S--, or --NR--;R is alkyl of 1-6 carbon atoms;R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are each, independently, hydrogen, halogen, alkyl, alkenyl, alkynyl, alkenyloxy, alkynyloxy, hydroxymethyl, halomethyl, alkanoyloxy, alkenoyloxy, alkynoyloxy, alkanoyloxymethyl, alkenoyloxymethyl, alkynoyloxymethyl, alkoxymethyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylsulfonamido, alkenylsulfonamido, alkynylsulfonamido, hydroxy, trifluoromethyl, cyano, nitro, carboxy, carboalkoxy, carboalkyl, phenoxy, phenyl, thiophenoxy, benzyl, amino, hydroxyamino, alkoxyamino, alkylamino, dialkylamino, aminoalkyl, N-alkylaminoalkyl, N,N-dialkylaminoalkyl, phenylamino, benzylamino, ##STR2## R.sub.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: December 14, 1999
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Bernard D. Johnson, Marvin F. Reich, Middleton B. Floyd, Jr., Douglas B. Kitchen, Hwei-Ru Tsou
  • 4-aminoquinazoline EGFR Inhibitors
    Patent number: 5760041
    Abstract: This invention provides a compound having the formula ##STR1## wherein: X is phenyl which is optionally substituted;R and R.sub.1 are each, independently, hydrogen, halogen, alkyl, alkoxy, hydroxy, or trifluoromethyl;R.sub.2 is hydrogen, alkyl, alkoxy, hydroxy, trifluoromethyl;Y is a radical selected from the group consisting of ##STR2## R.sub.3 is independently hydrogen, alkyl, carboxy, carboalkoxy, phenyl, or carboalkyl;n=2-4;or a pharmaceutically acceptable salt thereof, with the proviso that each R.sub.3 of Y may be the same or different which are useful as antineoplastic agents.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: June 2, 1998
    Assignee: American Cyanamid Company
    Inventors: Allan Wissner, Bernard D. Johnson, Middleton B. Floyd, Jr., Douglas B. Kitchen
  • 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
    Patent number: 4876252
    Abstract: This disclosure describes novel 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines having antiasthmatic activity.
    Type: Grant
    Filed: May 17, 1988
    Date of Patent: October 24, 1989
    Assignee: American Cyanamid Company
    Inventors: Lawrence W. Torley, Bernard D. Johnson, John P. Dusza
  • 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines
    Patent number: 4788195
    Abstract: This disclosure describes novel 4,5,6-substituted-N-(substituted-phenyl)-2-pyrimidinamines having anti-asthmatic activity.
    Type: Grant
    Filed: November 6, 1986
    Date of Patent: November 29, 1988
    Assignee: American Cyanamid Company
    Inventors: Lawrence W. Torley, Bernard D. Johnson, John P. Dusza