Patents by Inventor Bernard Danree

Bernard Danree has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5322846
    Abstract: The present invention relates to novel 4-methylthiazole derivatives, to tr methods of preparation and to the pharmaceutical compositions in which they are present.According to the invention, these derivatives have the general formula ##STR1## in which n is equal to 0 or 1 and R.sub.1 and R.sub.2, which are identical or different, are selected from a hydrogen atom, a halogen, a hydroxyl group, a trifluoromethyl group, an alkyl group having from 1 to 4 carbon atoms and an alkoxy group having from 1 to 5 carbon atoms and are useful in the treatment of cardiovascular diseases associated with hyperactivity of the sympathetic nervous system.
    Type: Grant
    Filed: October 19, 1992
    Date of Patent: June 21, 1994
    Assignee: Institut de Recherches Chimiques et Biologiques Appliquees (I.R.C.E.B.A.)
    Inventors: Fabienne Jobard-Rouppert, Patrick Houziaux, Jean-Pierre Riffaud, Jean-Yves Lacolle, Patrick Saur, Bernard Danree
  • Patent number: 5212161
    Abstract: The present invention relates to novel derivatives of 2'-deoxyuridine substituted in the 5-, 3'- or 5'-position by .alpha.-aminoacyl groups, to a process for their preparation and the drugs in which they are present.These derivatives have the following general formula: ##STR1## in which R is selected from an alkyl or alkenyl radical having from 1 to 4 carbon atoms, an aryl radical or a halogen, it being possible for said alkyl, alkenyl and aryl radicals to contain at least one halogen substituent, and a radical of the formula --NH--R.sub.1, in which R.sub.1 is an amino acid residue or a peptide residue containing from 2 to 6 amino acids; andR' and R" are selected from a hydroxyl radical and a radical of the formula --NH--R.sub.1, in which R.sub.1 is as defined above,with the proviso that R' and R" are not simultaneously --NH--R.sub.1 and that, when R is --NH--R.sub.1, R' and R" are simultaneously a hydroxyl group.Application: treatment of cancers and viral infections.
    Type: Grant
    Filed: August 17, 1990
    Date of Patent: May 18, 1993
    Assignee: Institut de Recherches Chimiques et Biologiques Appliquees (I.R.C.E.B.A.)
    Inventors: Jean-Luc Moriniere, Michelle Faulques, Claude Rousseau, Bernard Danree, Claude Marquer, Patrick Saur, Jean Lemoine, Jean-Yves Lacolle
  • Patent number: 5120736
    Abstract: The present invention relates to novel 4-methyl-5-[2-(4-phenylpiperazin-1-yl)ethyl]thiazole derivatives of the general formula ##STR1## in which R is selected from a hydrogen atom, an alkyl radical having from 2 to 7 carbon atoms and an aralkyl radical of which the aryl moiety preferably consists of phenyl and of which the alkyl moiety has from 1 to 4 carbon atoms, and to the pharmaceutically acceptable salts of these derivatives.It further relates to a method of preparing these products and to pharmaceutical compositions in which they are incorporated.These derivatives are applied especially in the preparation of drugs intended for the treatment of functional dysuria associated with hyperactivity of the .alpha.-adrenergic sympathetic nervous system.
    Type: Grant
    Filed: April 11, 1991
    Date of Patent: June 9, 1992
    Assignee: Institut de Recherches Chimiques et Biologiques Appliquees
    Inventors: Patrick Houziaux, Jean-Pierre Riffaud, Jean-Yves LaColle, Bernard Danree
  • Patent number: 5110816
    Abstract: The present invention relates to the products of general formula (I): ##STR1## in which R.sub.1 and R.sub.2 are identical or different and are selected om a hydrogen atom, a halogen atom, a hydroxyl radical, an alkyl radical having from 1 to 5 (sic) carbon atoms, an alkoxy radical having from 1 to 5 carbon atoms or a phenoxy, benzyloxy, trifluoromethyl or acetyl radical.It further relates toa method of preparing said productsand the drugs in which said products are present.
    Type: Grant
    Filed: December 12, 1990
    Date of Patent: May 5, 1992
    Assignee: Institut de Recherches Chimiques et Biologiques Appliquees (I.R.C.E.B.A.)
    Inventors: Patrick Houziaux, Jean-Pierre Riffaud, Jean-Yves Lacolle, Bernard Danree
  • Patent number: 4960900
    Abstract: The present invention relates, by way of novel industrial products, to the ollowing oxyimino derivatives of thiazole: (a) the E and Z diastereoisomers of the formula ##STR1## in which R.sub.1 represents H, F, Cl, Br, CF.sub.3 or CH.sub.3 and R.sub.2 represents a C.sub.1 -C.sub.10 -alkyl group, a benzyl group of the formula CH.sub.2 C.sub.6 H.sub.2 (R.sub.3).sub.3, in which each R.sub.3 identical or different represents H, F,Cl,Br, CF.sub.3, a C.sub.1 -C.sub.4 -alkyl group or a C.sub.1 -C.sub.4 -alkoxy group, a group CH.sub.2 COOR.sub.4, in which R.sub.4 represents H, a C.sub.1 -C.sub.4 -alkyl group or the ammonium group, NH.sub.4.sup.+, a group CH.sub.2 COOM.sub.m, in which M is an alkali metal or alkaline earth metal and m is its valency, or a 2-aminoethyl group of the formula CH.sub.2 CH.sub.2 NR.sub.5 R.sub.6, in which R.sub.5 and R.sub.6, which can be identical or different each represent H or a C.sub.1 -C.sub.4 -alkyl group, it being possible for R.sub.5 and R.sub.
    Type: Grant
    Filed: December 23, 1988
    Date of Patent: October 2, 1990
    Assignee: Institut de Ercherches Chimiques et Biologiques Appliquees (I.R.C.E.B.A.)
    Inventors: Bernard Danree, Patrick Houziaux, Jean-Yves Lacolle, Jean-Pierre Riffaud
  • Patent number: 4880807
    Abstract: The present invention relates, by way of novel industrial products, to(i) 4-aryl-1-nicotinoylpiperazines of the formula ##STR1## in which R.sub.1 and R.sub.2, which can be identical or different, each represent the hydrogen atom, a halogen atom (especially F, Cl or Br) or a CF.sub.3, C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or C.sub.2 -C.sub.4 -acyl group; and(ii) addition salts thereof.These products are useful in therapy as anticonvulsants.
    Type: Grant
    Filed: December 7, 1988
    Date of Patent: November 14, 1989
    Assignee: Institut De Recherches Chimiques et Biologiques Appliquees (I.R.C.E.B.A.)
    Inventors: Bernard Danree, Michelle Faulques, Jean-Yves Lacolle, Jean-Pierre Riffaud
  • Patent number: 4795758
    Abstract: The present invention relates to novel products of the formula: ##STR1## in which R is selected from the group comprising H, OH, --O--COCH.sub.3 and --O--CO--(CH.sub.2).sub.n --CH.sub.3, in which n is between 1 and 8, and the salts of the products of the formula (I) with pharmaceutically acceptable acids.
    Type: Grant
    Filed: May 15, 1987
    Date of Patent: January 3, 1989
    Assignee: Societe a Responsabilite Limitee: Institut de Recherches Chimiques et Biologiques Appliquees (I.R.C.E.B.A.)
    Inventors: Bernard Danree, Patrick Houziaux, Jean-Yves Lacolle
  • Patent number: 4678810
    Abstract: The invention relates to halogenobenzophenone-oxime derivatives of the general formula ##STR1## wherein R is C.sub.3 -C.sub.8 alkyl with a branched hydrocarbon chain, and Ar is a halogenophenyl group of the formula ##STR2## in which R.sub.1 is F, Cl or Br, and R.sub.2 and R.sub.3, identical or different, represent each H, F, Cl or Br.The derivatives of formula I are useful as antibacterial agents.
    Type: Grant
    Filed: February 26, 1986
    Date of Patent: July 7, 1987
    Assignee: Institut de Recherches Chimiques et Biologiques of Appliques (I.R.C.E.B.A.)
    Inventor: Bernard Danree
  • Patent number: 4659741
    Abstract: This invention is concerned with new .beta.-[2-(halogenobenzyl)-phenoxy]-ylamine derivatives of the general formula ##STR1## wherein R represents a C.sub.1 -C.sub.8 -alkyl group having a linear or branched hydrocarbon chain,R.sub.1 and R.sub.2, which may identical or different, represent each a C.sub.1 -C.sub.4 -alkyl-group, andAr represents a polychlorophenyl group of the formula ##STR2## (in which Y.sub.1 is 4-Cl, Y.sub.2 is H or Cl, and Y.sub.3 is H or Cl, at least one of the Y.sub.2 and Y.sub.3 being Cl); and their addition salts.These new compounds are useful as pharmaceuticals.
    Type: Grant
    Filed: November 27, 1984
    Date of Patent: April 21, 1987
    Assignee: Institut de Recherches Chimiques et Biologiques Appliquees (I.R.C.E.B.A)
    Inventors: Jean-Yves Lacolle, Bernard Danree