Abstract: The invention relates to a method for determining the microvascular resistance reserve, MRR, in the myocardium perfused by a normal or a stenotic coronary artery of a human patient, which method comprises the step of during rest condition of the patient: measuring the blood flow, Qrest, through the coronary artery; and further comprising the step of during rest condition or during maximum hyperemia of the patient: measuring the blood pressure, Pa, at a position proximal in the coronary artery or proximally of any stenosis, if present; and further comprising the steps of during maximum hyperemia of the patient: measuring the blood flow, Qmax, through the coronary artery; and measuring the blood pressure, Pd, at a position distal in the coronary artery or distally of any stenosis, if present, and wherein the microvascular resistance reserve, MRR, is determined by the additional step of calculating the microvascular resistance reserve as M ? R ? R = Q max Q rest ? P a P d , h ? y ? p ? e ? r

Abstract: A catheter system and a method for performing body obstruction destruction are disclosed. The catheter comprises a catheter shaft comprising a proximal end and a distal end, including an outer tubular member and at least one inner tubular member disposed within the outer tubular member; a first fluid lumen defined between the inner tubular member and the outer tubular member and at least one second lumen defined by the inner tubular member; one or more fluid exit openings located at a distal end region of the catheter configured to permit fluid to exit the catheter from the first fluid lumen; fluid pressure means located external of the catheter ahead from the proximal end for delivering said fluid in the first fluid lumen at a pressure range predetermined to cause destruction of said obstruction.

Abstract: The invention relates to a method for determining the microvascular resistance reserve, MRR, in the myocardium perfused by a normal or a stenotic coronary artery of a human patient, which method comprises the step of during rest condition of the patient: measuring the blood flow, Qrest, through the coronary artery; and further comprising the step of during rest condition or during maximum hyperemia of the patient: measuring the blood pressure, Pa, at a position proximal in the coronary artery or proximally of any stenosis, if present; and further comprising the steps of during maximum hyperemia of the patient: measuring the blood flow, Qmax, through the coronary artery; and measuring the blood pressure, Pd, at a position distal in the coronary artery or distally of any stenosis, if present, and wherein the microvascular resistance reserve, MRR, is determined by the additional step of calculating the microvascular resistance reserve as M ? R ? R = Q max Q rest ? P a P d , h ? y ? p ? e ? r

Abstract: The invention relates to an infusion catheter device. This catheter device 10 has an elongate, substantially tubular shape defining a longitudinal axis, a distal end (D) and a proximal end (P), configured to be introduced into a conduit (50) having an inner wall (54) and an outer wall (56) and comprising at least one partial or total obstruction (60) or occlusion to be treated, said device comprising, at its distal end (D), one or more infusion orifices (16, 18, 20, 22) for an infusion liquid (LI), and, upstream from the one or more infusion orifices, at the proximal side (P) of the infusion catheter (10), at least one obturating element (70) for temporary obturating, configured to treat said obstruction (60) or occlusion and to perform the infusion of the infusion liquid (LI) downstream from the obturating element (70) and in the obturating position. This device is suitable in particular for cardiac surgery and interventional cardiology.

Abstract: A method for measuring cardiac pressure includes positioning a fluid-filled catheter and a pressure wire sensor at a cardiac pressure calibration location. A first pressure measurement is acquired from the fluid-filled catheter and a second pressure measurement is acquired from the pressure wire sensor. A set of equalization parameters is identified to apply to the first pressure measurement to reduce an error between the first pressure measurement and the second pressure measurement. The equalization parameters include a frequency correction parameter and a damping correction parameter to correct for frequency and damping of oscillations in the first pressure measurement. A third pressure measurement is acquired from the fluid-filled catheter. The set of equalization parameters is applied to equalize the third pressure measurement.

Abstract: A catheter system and a method for performing body obstruction destruction are disclosed. The catheter comprises a catheter shaft comprising a proximal end and a distal end, including an outer tubular member and at least one inner tubular member disposed within the outer tubular member; a first fluid lumen defined between the inner tubular member and the outer tubular member and at least one second lumen defined by the inner tubular member; one or more fluid exit openings located at a distal end region of the catheter configured to permit fluid to exit the catheter from the first fluid lumen; fluid pressure means located external of the catheter ahead from the proximal end for delivering said fluid in the first fluid lumen at a pressure range predetermined to cause destruction of said obstruction.

Abstract: Catheter systems and methods for determining blood flow rates based on temperature measurements by thermodilution. The catheter may include a fluid lumen defined between inner and outer tubular members for delivering an indicator fluid, and a guidewire lumen defined by the inner tubular member. The catheter may include fluid infusion openings at the distal end region of the outer tubular member configured to permit the indicator fluid to exit the catheter from the fluid lumen, and a fluid hole located at the distal end region of the inner tubular member configured to permit the indicator fluid to pass from the fluid lumen into the guidewire lumen. A temperature sensor positioned on a guidewire may be positioned within the guidewire lumen to measure the temperature of the indicator fluid entering the guidewire lumen through the fluid hole. A blood flow rate may be calculated based on the measured temperature.

Abstract: The invention relates to an infusion catheter device. This catheter device 10 has an elongate, substantially tubular shape defining a longitudinal axis, a distal end (D) and a proximal end (P), configured to be introduced into a conduit (50) having an inner wall (54) and an outer wall (56) and comprising at least one partial or total obstruction (60) or occlusion to be treated, said device comprising, at its distal end (D), one or more infusion orifices (16, 18, 20, 22) for an infusion liquid (LI), and, upstream from the one or more infusion orifices, at the proximal side (P) of the infusion catheter (10), at least one obturating element (70) for temporary obturating, configured to treat said obstruction (60) or occlusion and to perform the infusion of the infusion liquid (LI) downstream from the obturating element (70) and in the obturating position. This device is suitable in particular for cardiac surgery and interventional cardiology.