Abstract: The present invention provides compositions useful as antimicrobial agents which include mammalian hemoglobin, the &agr; and &bgr; chains of hemoglobin free of heme, fragments of the &agr; and &bgr; chains that result from cyanogen bromide cleavage of the &agr; and &bgr; chains, and synthetic peptides derived therefrom. The compositions exert antimicrobial activity against both bacteria and fungi that is comparable to known antimicrobial peptides from human neutrophils, cathepsin G and azurocidin. Sensitive organisms include Gram-negative bacteria such as Escherichia coli and Pseudomonas aeruginosa, Gram-positive bacteria such as Staphylococcus aureus and Streptococcus faecalis, and the fungus Candida albicans. Methods for preparing the compositions also are provided.

Abstract: This invention relates to a method of treating glaucoma or reducing intraocular pressure in a patient in need of such treatment which is based on the topical administration to the eye of a mammal or the systemic administration of a compound of the formula: ##STR1## wherein E', W', and the R groups are defined in the disclosure.

Abstract: Substituted 5-2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles having the structural formula: ##STR1## wherein R4, R5, R6, R7, and R8 are as hereinafter defined, are .beta.3-adrenergic agonists useful in the treatment of elevated intraocular pressure and glaucoma.