Abstract: The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of osteoarthritis in mammals, advantageously in humans, dogs, horses and cats, by intra-articular administration of the recombinant vectors and pharmaceutical compositions of the invention.

Abstract: The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in dogs and cats, by administration of the recombinant vectors and pharmaceutical compositions of the invention.

Abstract: The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in dogs and cats, by administration of the recombinant vectors and pharmaceutical compositions of the invention.

Abstract: The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of osteoarthritis in mammals, advantageously in humans, dogs, horses and cats, by intra-articular administration of the recombinant vectors and pharmaceutical compositions of the invention.

Abstract: The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in dogs and cats, by administration of the recombinant vectors and pharmaceutical compositions of the invention.

Abstract: The present invention relates to recombinant vectors expressing the BMP-7 polypeptide in host cells and to pharmaceutical compositions comprising such recombinant vectors. The invention also encompasses methods for prevention and/or treatment of both acute and chronic renal failure in mammals, advantageously in humans, dogs and cats, by intra-vascular kidney administration of the recombinant vectors and pharmaceutical compositions of the invention.

Abstract: The present invention relates to a canine pre-proGHRH polypeptide, a canine mature GHRH peptide, an isolated polynucleotide which encodes the canine pre-proGHRH or the canine mature GHRH. The invention also encompasses vectors encoding and expressing the canine pre-proGHRH or the canine GHRH which can be used to treat disease and growth hormone deficiencies by gene therapy in vertebrates, in particular in dogs.

Abstract: The present invention relates to a canine pre-proGHRH polypeptide, a canine mature GHRH peptide, an isolated polynucleotide which encodes the canine pre-proGHRH or the canine mature GHRH. The invention also encompasses vectors encoding and expressing the canine pre-proGHRH or the canine GHRH which can be used to treat disease and growth hormone deficiencies by gene therapy in vertebrates, in particular in dogs.

Abstract: A process for decomposing a cumene oxidation product mixture containing cumene hydroperoxide (CHP) and dimethylphenyl carbinol (DMPC) to produce phenol, acetone and alpha-methyl styrene (AMS) with enhanced safety of operation and reduced by-product formation which comprises the steps:

Abstract: A process for selectively separating polyamides from multi-component waste materials including the steps of subjecting the multi-component mix to a specific mixture of caprolactam and water at a preselected temperature range below the degradation temperature of the polymer to be recovered, separating the formed polyamide solution, and recovering the desired polyamide. The process is very desirable for separating multi-component waste materials which contain not only nylon 6, but also nylon 6,6. The recovered polyamide may be used in molding applications and in fiber such as carpet fiber.

Abstract: A single stepper motor is utilized in a printing device to lift a print head from the surface of recording material upon the initial angular rotation of the stepper motor output drive shaft and to move the recording material within the printing device upon further rotation of said drive shaft. The print head is returned to the surface of the recording material by operating the stepper motor in the reverse direction until the output drive shaft of the stepper motor traverses an angular displacement equal but opposite to the initial angular displacement. A cam surface couples the output drive shaft of the stepper motor to a drive gear and transforms the initial angular displacement of the output drive shaft into linear motion to lift the print head from the surface of the recording material. Further rotation of the stepper motor drive shaft rotates the drive gear to move material within the printing device.

Abstract: A transistorized circuit is used for controlling the flow of current through a high voltage source, such as a battery. The high voltage source must be capable of being tapped at voltages less than the critical voltage of the transistors in the circuit, that is, that voltage at the maximum current through the transistor, above which the breakdown characteristics or maximum power dissipation ability of the transistor is exceeded. A plurality of transistor arrays are connected in series with each other, and each array is connected to a tap on the voltage source. Each array includes parallel connected transistors in sufficient quantity to achieve the desired current flow. The current through each array is made equal by control circuits so that no current flows through the tapped connection to the voltage source. The transistorized circuit may be used to control both the charging and the discharging rate of current through a high voltage battery.

Abstract: In production of cyclohexanone by hydrogenating phenol in the presence of a hydrogenation catalyst, improved catalyst life and improved hydrogenation rate are obtained if ketone impurities, particularly hydroxyacetone, are removed from the phenol prior to the hydrogenation. The present invention provides an improved method for reducing the ketone impurities in the phenol by contacting the phenol with a polyethylenimine and distilling the mixture formed to separate the phenol. The invention is particularly useful in production of cyclohexanone from phenol obtained by decomposition of cumene hydroperoxide.

Abstract: An improved process and apparatus for production of synthetic multifilamentary yarns having uniform quality. The method comprises extruding a molten synthetic polymer downwardly through a spinneret, advancing the extruded filaments downwardly through a substantially stationary column of heated air, and subsequently advancing the filaments downwardly through a quenching zone wherein they are in contact with cooling air introduced into the path of the filaments under controlled conditions of air velocity and direction of flow.

Abstract: A method and apparatus for off-line testing and correcting the metering accuracy of a split multihole spinneret fed by a single metered stream by determining end to end variations in flow rate and by reworking a number of holes in the lower flow rate side of the split spinneret, calculated by multiplying the average test percent bias of the split spinneret by a predetermined constant, so as to bring end to end variations in flow rate to within a required accuracy.

Abstract: An improved process and apparatus for production of synthetic multifilamentary yarns having uniform quality. The method comprises extruding a molten synthetic polymer downwardly through a spinneret, advancing the extruded filaments downwardly through a substantially stationary column of heated air, and subsequently advancing the filaments downwardly through a quenching zone wherein they are in contact with cooling air introduced into the path of the filaments under controlled conditions of air velocity and direction of flow.

Abstract: A method and apparatus for off-line testing and correcting the metering accuracy of a split multihole spinneret fed by a single metered stream by determining end to end variations in flow rate and by reworking a number of holes in the lower flow rate side of the split spinneret, calculated by multiplying the average test percent bias of the split spinneret by a predetermined constant, so as to bring end to end variations in flow rate to within a required accuracy.