Patents by Inventor Bernard Francis McDonald
Bernard Francis McDonald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240115657Abstract: A composition comprises a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising an active principle. The invention includes embodiments in which the active principle is included in at least some of the oil droplets as well as embodiments in which the oil droplets are released as the matrix containing them dissolves in an aqueous medium. In one embodiment, the oil droplets are substantially immobilized in or by the matrix and the immobilizing feature is lost as the matrix dissolves in aqueous media. In certain embodiments, the oil drops may collectively be referred to as the oil phase of the composition of the invention. The product may be in the form of mini-beads. The oil phase and/or the polymer matrix may each include a surfactant.Type: ApplicationFiled: April 19, 2023Publication date: April 11, 2024Applicant: Sublimity Therapeutics LimitedInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa
-
Publication number: 20240100122Abstract: The present invention relates to a formulation comprising a pharmaceutically active ingredient and a coating. The invention also relates to the use of the formulation in the treatment and prevention of disorders of the gastrointestinal tract. Also disclosed are methods for preparing the formulations.Type: ApplicationFiled: April 19, 2023Publication date: March 28, 2024Applicant: Sublimity Therapeutics LimitedInventors: Ivan Coulter, Vincenzo Aversa, Bernard Francis McDonald, Monica Rosa
-
Publication number: 20220080026Abstract: The present invention relates to a formulation comprising a pharmaceutically active ingredient and a coating. The invention also relates to the use of the formulation in the treatment and prevention of disorders of the gastrointestinal tract. Also disclosed are methods for preparing the formulations.Type: ApplicationFiled: April 30, 2021Publication date: March 17, 2022Applicant: Sublimity Therapeutics LimitedInventors: Ivan Coulter, Vincenzo Aversa, Bernard Francis McDonald, Monica Rosa
-
Publication number: 20210338768Abstract: A composition comprises a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising an active principle. The invention includes embodiments in which the active principle is included in at least some of the oil droplets as well as embodiments in which the oil droplets are released as the matrix containing them dissolves in an aqueous medium. In one embodiment, the oil droplets are substantially immobilized in or by the matrix and the immobilizing feature is lost as the matrix dissolves in aqueous media. In certain embodiments, the oil drops may collectively be referred to as the oil phase of the composition of the invention. The product may be in the form of mini-beads. The oil phase and/or the polymer matrix may each include a surfactant.Type: ApplicationFiled: December 10, 2020Publication date: November 4, 2021Applicant: Sublimity Therapeutics LimitedInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa
-
Publication number: 20190381131Abstract: The present invention relates to a formulation comprising a pharmaceutically active ingredient and a coating. The invention also relates to the use of the formulation in the treatment and prevention of disorders of the gastrointestinal tract. Also disclosed are methods for preparing the formulations.Type: ApplicationFiled: July 2, 2019Publication date: December 19, 2019Applicant: Sublimity Therapeutics LimitedInventors: Ivan Coulter, Vincenzo Aversa, Mónica Rosa, Bernard Francis McDonald
-
Patent number: 10434138Abstract: The present invention relates to a formulation comprising a pharmaceutically active ingredient and a coating. The invention also relates to the use of the formulation in the treatment and prevention of disorders of the gastrointestinal tract. Also disclosed are methods for preparing the formulations.Type: GrantFiled: November 7, 2014Date of Patent: October 8, 2019Assignee: Sublimity Therapeutics LimitedInventors: Ivan Coulter, Vincenzo Aversa, Mónica Rosa, Bernard Francis McDonald
-
Publication number: 20180264076Abstract: A composition comprises a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising an active principle. The invention includes embodiments in which the active principle is included in at least some of the oil droplets as well as embodiments in which the oil droplets are released as the matrix containing them dissolves in an aqueous medium. In one embodiment, the oil droplets are substantially immobilized in or by the matrix and the immobilizing feature is lost as the matrix dissolves in aqueous media. In certain embodiments, the oil drops may collectively be referred to as the oil phase of the composition of the invention. The product may be in the form of mini-beads. The oil phase and/or the polymer matrix may each include a surfactant.Type: ApplicationFiled: May 22, 2018Publication date: September 20, 2018Applicant: Sigmoid Pharma LimitedInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa
-
Patent number: 9999651Abstract: A composition comprises a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising an active principle. The invention includes embodiments in which the active principle is included in at least some of the oil droplets as well as embodiments in which the oil droplets are free of active principle. The oil droplets are released as the matrix containing them dissolves in an aqueous medium. In one embodiment, the oil droplets are substantially immobilized in or by the matrix and the immobilizing feature is lost as the matrix dissolves in aqueous media. In certain embodiments, the oil drops may collectively be referred to as the oil phase of the composition of the invention. The product may be in the form of mini-beads. The oil phase and/or the polymer matrix may each include a surfactant.Type: GrantFiled: January 29, 2016Date of Patent: June 19, 2018Assignee: Sigmoid Pharma LimitedInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa
-
Patent number: 9950051Abstract: This invention relates to compositions for delivering one or more active ingredients, and more particularly to compositions, e.g. beads, comprising a matrix material which matrix material comprises a microorganism. In particular, the invention relates to compositions comprising a microorganism selected from live, killed, attenuated and inactivated microorganisms. The matrix material may also comprise a surfactant and may further comprise an adjuvant. The invention further relates to the manufacture and use of such compositions, and to other subject matter.Type: GrantFiled: October 27, 2015Date of Patent: April 24, 2018Assignee: Sigmoid Pharma LimitedInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa, Monica Torres Rosa
-
Publication number: 20180071387Abstract: A pharmaceutical composition comprising a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising at least one immunomodulator selected from an adjuvant, an antigen or a combination thereof. A method of manufacturing shaped compositions comprises mixing an aqueous solution of a water-soluble polymer with an oil-based liquid to form a water-in-oil emulsion, at least one of the aqueous solution and the oil-based liquid comprising an antigen or an adjuvant or a combination thereof, and then causing or allowing the resultant suspension to solidify into one or more beads or other shaped elements.Type: ApplicationFiled: November 15, 2017Publication date: March 15, 2018Applicant: Sigmoid Pharma LimitedInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa, Mónica Torres Rosa, Edward Charles Lavelle
-
Publication number: 20180042989Abstract: Immunomodulator formulations for use in the treatment of disease of the GI tract. The formulations comprise a hydroxylase inhibitor and/or an immunosuppressant. Exemplary formulations comprise hydralazine as a hydroxylase inhibitor and/or cyclosporin A as an immunosuppressant.Type: ApplicationFiled: October 23, 2017Publication date: February 15, 2018Applicant: Sigmoid Pharma LimitedInventors: Vincenzo Aversa, Ivan Coulter, Mónica Torres Rosa, Bernard Francis McDonald
-
Patent number: 9878036Abstract: A pharmaceutical composition comprising a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising at least one immunomodulator selected from an adjuvant, an antigen or a combination thereof. A method of manufacturing shaped compositions comprises mixing an aqueous solution of a water-soluble polymer with an oil-based liquid to form a water-in-oil emulsion, at least one of the aqueous solution and the oil-based liquid comprising an antigen or an adjuvant or a combination thereof, and then causing or allowing the resultant suspension to solidify into one or more beads or other shaped elements.Type: GrantFiled: August 12, 2010Date of Patent: January 30, 2018Assignee: Sigmoid Pharma LimitedInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa, Monica Torres Rosa, Edward Charles Lavelle
-
Patent number: 9821024Abstract: Immunomodulator formulations for use in the treatment of disease of the GI tract. The formulations comprise a hydroxylase inhibitor and/or an immunosuppressant. Exemplary formulations comprise hydralazine as a hydroxylase inhibitor and/or cyclosporin A as an immunosuppressant.Type: GrantFiled: November 25, 2011Date of Patent: November 21, 2017Assignee: Sigmoid Pharma LimitedInventors: Vincenzo Aversa, Ivan Coulter, Mónica Torres Rosa, Bernard Francis McDonald
-
Publication number: 20160310561Abstract: The present invention relates to a formulation comprising a pharmaceutically active ingredient and a coating. The invention also relates to the use of the formulation in the treatment and prevention of disorders of the gastrointestinal tract. Also disclosed are methods for preparing the formulations.Type: ApplicationFiled: November 7, 2014Publication date: October 27, 2016Applicant: Sigmoid Pharma LimitedInventors: Ivan Coulter, Vincenzo Aversa, Bernard Francis McDonald, Monica Rosa
-
Publication number: 20160143989Abstract: A composition comprises a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising an active principle. The invention includes embodiments in which the active principle is included in at least some of the oil droplets as well as embodiments in which the oil droplets are free of active principle. The oil droplets are released as the matrix containing them dissolves in an aqueous medium. In one embodiment, the oil droplets are substantially immobilized in or by the matrix and the immobilizing feature is lost as the matrix dissolves in aqueous media. In certain embodiments, the oil drops may collectively be referred to as the oil phase of the composition of the invention. The product may be in the form of mini-beads. The oil phase and/or the polymer matrix may each include a surfactant.Type: ApplicationFiled: January 29, 2016Publication date: May 26, 2016Applicant: Sigmoid Pharma LimitedInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa
-
Patent number: 9278070Abstract: A composition comprises a water-soluble polymer matrix in which are dispersed droplets of oil, the composition comprising an active principle. The invention includes embodiments in which the active principle is included in at least some of the oil droplets as well as embodiments in which the oil droplets are free of active principle. The oil droplets are released as the matrix containing them dissolves in an aqueous medium. In one embodiment, the oil droplets are substantially immobilized in or by the matrix and the immobilizing feature is lost as the matrix dissolves in aqueous media. In certain embodiments, the oil drops may collectively be referred to as the oil phase of the composition of the invention. The product may be in the form of mini-beads. The oil phase and/or the polymer matrix may each include a surfactant.Type: GrantFiled: May 18, 2010Date of Patent: March 8, 2016Assignee: Sigmoid Pharma LimitedInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa
-
Publication number: 20160045585Abstract: This invention relates to compositions for delivering one or more active ingredients, and more particularly to compositions, e.g. beads, comprising a matrix material which matrix material comprises a microorganism. In particular, the invention relates to compositions comprising a microorganism selected from live, killed, attenuated and inactivated microorganisms. The matrix material may also comprise a surfactant and may further comprise an adjuvant. The invention further relates to the manufacture and use of such compositions, and to other subject matter.Type: ApplicationFiled: October 27, 2015Publication date: February 18, 2016Applicant: SIGMOID PHARMA LIMITEDInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa, Monica Torres Rosa
-
Patent number: 9220681Abstract: This invention relates to compositions for delivering one or more active ingredients, and more particularly to compositions, e.g. beads, comprising a matrix material which matrix material comprises a microorganism. In particular, the invention relates to compositions comprising a microorganism selected from live, killed, attenuated and inactivated microorganisms. The matrix material may also comprise a surfactant and may further comprise an adjuvant. The invention further relates to the manufacture and use of such compositions, and to other subject matter.Type: GrantFiled: July 5, 2013Date of Patent: December 29, 2015Assignee: Sigmoid Pharma LimitedInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa, Mónica Rosa
-
Publication number: 20150342893Abstract: An oral celecoxib formulation, the formulation being a multiple minibead formulation wherein the minibeads comprise a hydrogel-forming polymer matrix in which are distributed celecoxib, a polyoxyethylated non-ionic surfactant and an anionic surfactant, the minibeads when combined with water being capable of releasing self-assembly structures comprising surfactant and celecoxib. The formulation may be used for treating colorectal cancer, e.g. for inhibiting, reducing or delaying the initiation and/or progression of colorectal cancer, or for use in reversing colorectal cancer, reducing the burden of colorectal cancer and/or inducing remission of colorectal cancer, or for inhibiting, reducing or delaying metastasis of a colorectal cancer.Type: ApplicationFiled: May 27, 2015Publication date: December 3, 2015Applicant: SIGMOID PHARMA LIMITEDInventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa
-
Publication number: 20150182456Abstract: This invention relates to compositions for delivering one or more active ingredients, and more particularly to compositions, e.g. beads, comprising a matrix material which matrix material comprises a microorganism. In particular, the invention relates to compositions comprising a microorganism selected from live, killed, attenuated and inactivated microorganisms. The matrix material may also comprise a surfactant and may further comprise an adjuvant. The invention further relates to the manufacture and use of such compositions, and to other subject matter.Type: ApplicationFiled: July 5, 2013Publication date: July 2, 2015Applicant: Sigmoid Pharma Ltd.Inventors: Ivan Coulter, Bernard Francis McDonald, Vincenzo Aversa, Mónica Torres Rosa