Patents by Inventor Bernard Freiss
Bernard Freiss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9243076Abstract: The invention relates to a method for preparing a soluble inclusion complex comprising one or several active substances which are hardly soluble in an aqueous medium and are included in one or several host molecules, using the following successive stages: (a) bringing one or several active substances into contact with one or several host molecules; (b) initiating a molecular diffusion stage by bringing a dense pressurized fluid into contact with the mixture obtained in (a) in a static mode in the presence of one or several diffusing agents; (c) recovering the active substance-host molecule molecular complex formed; (d) adding and mixing an interaction agent with the active substance-host molecule molecular complex; (e) recovering the soluble inclusion compound thus formed. The invention also relates to the soluble inclusion compound obtained by the method, particularly a piroxicam-cyclodextrin-arginine compound.Type: GrantFiled: April 30, 2013Date of Patent: January 26, 2016Assignee: PIERRE FABRE MEDICAMENTInventors: Bernard Freiss, Florence Marciacq, Hubert Lochard
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Patent number: 9028806Abstract: The present invention relates to a batch method for impregnating a nonporous polymer pharmaceutical carrier with an active substance, characterized in that said method includes the following consecutive steps: a) mixing the active substance and the nonporous polymer pharmaceutical carrier, the pharmaceutical carrier being in a solid form and insoluble in supercritical CO2 and not being non-crosslinked polyvinylpyrrolidone; b) performing a step of molecular diffusion in the absence of water by contacting, in a static mode without agitation, the mixture obtained in step a) with supercritical CO2 at a pressure of 80 to 170 bars, at a temperature of 31 to 90° C. for 1 to 6 hours; c) recovering the polymer pharmaceutical carrier impregnated with the active substance obtained in step b), the impregnated pharmaceutical carrier being nonporous and being in a solid form and the active substance being in an amorphous form, the method being implemented in the absence of an additional solvent.Type: GrantFiled: May 12, 2010Date of Patent: May 12, 2015Assignee: Pierre Fabre MedicamentInventors: Hubert Lochard, Bernard Freiss
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Patent number: 8741346Abstract: The invention relates to a method for the preparation of soluble molecular complexes, comprising one or more active substances which are poorly-soluble in an aqueous medium, included within one or more host molecules, characterized in comprising the following steps: (a) bringing one or more active substances into contact with one or more host molecules, (b) carrying out a molecular diffusion step by bringing a dense fluid into contact, under pressure, with the mixture obtained in (a), in static mode, in the presence of one or more diffusion agents and (c) recovery of the molecular complex thus formed.Type: GrantFiled: April 23, 2004Date of Patent: June 3, 2014Assignee: Pierre Fabre MedicamentInventors: Hubert Lochard, Martial Sauceau, Bernard Freiss
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Patent number: 8716342Abstract: A method for preparing molecular complexes between Adapalene and cyclodextrins using the technology of dense fluids under pressure, especially that of CO2 is described.Type: GrantFiled: April 9, 2010Date of Patent: May 6, 2014Assignee: Galderma Research & DevelopmentInventors: Hubert Lochard, Bernard Freiss
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Patent number: 8461133Abstract: The invention relates to a method for preparing a soluble inclusion complex comprising one or several active substances which are hardly soluble in an aqueous medium and are included in one or several host molecules, characterised in that it comprises the following succesive stages: (a) one or several active substances are brought into contact with one or several host molecules; (b) initiation of a molecular diffusion stage by bringing a dense pressurized fluid into contact with the mixture obtained in stage (a) in a static mode in the presence of one or several diffusing agents; (c) recovery of the active substance- host molecule molecular complex thus formed; (d) initiation of a stage wherein an interaction agent is added to and mixed with the active substance host molecule molecular complex; (e) recovery of the soluble inclusion compound thus formed. The invention also relates to the soluble inclusion compound which can be obtained by said method, particularly a piroxicam-cyclodextrin-arginine compound.Type: GrantFiled: March 29, 2005Date of Patent: June 11, 2013Assignee: Pierre Fabre MedicamentInventors: Bernard Freiss, Florence Marciaçq, Hubert Lochard
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Publication number: 20120077970Abstract: A method for preparing molecular complexes between Adapalene and cyclodextrins using the technology of dense fluids under pressure, especially that of CO2 is described.Type: ApplicationFiled: April 9, 2010Publication date: March 29, 2012Applicant: Galderma Research & DevelopmentInventors: Hubert Lochard, Bernard Freiss
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Publication number: 20120064130Abstract: The present invention relates to a batch method for impregnating a nonporous polymer pharmaceutical carrier with an active substance, characterised in that said method includes the following consecutive steps: a) mixing the active substance and the nonporous polymer pharmaceutical carrier, the pharmaceutical carrier being in a solid form and insoluble in supercritical CO2 and not being non-crosslinked polyvinylpyrrolidone; b) performing a step of molecular diffusion in the absence of water by contacting, in a static mode without agitation, the mixture obtained in step a) with supercritical CO2 at a pressure of 80 to 170 bars, at a temperature of 31 to 90° C. for 1 to 6 hours; c) recovering the polymer pharmaceutical carrier impregnated with the active substance obtained in step b), the impregnated pharmaceutical carrier being nonporous and being in a solid form and the active substance being in an amorphous form, the method being implemented in the absence of an additional solvent.Type: ApplicationFiled: May 12, 2010Publication date: March 15, 2012Applicant: PIERRE FABRE MEDICAMENTInventors: Hubert Lochard, Bernard Freiss
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Publication number: 20110124728Abstract: The present invention relates to a continuous process of DHA enrichment of a solution of fatty acids or derivatives thereof comprising less than 50% of DHA relative to the total fatty acids of the solution or to derivatives thereof, wherein the process comprises the steps of (a) simultaneous countercurrent injection, into a fractionation column, of the flow of the solution of fatty acids or of derivatives thereof and of a flow of supercritical CO2 at a temperature of less than or equal to 70° C. and at a pressure of between 100×105 Pa and 160×105 Pa, wherein the level of supercritical CO2 is between 30 and 70, and (b) recovery of the residue comprising at least 50% of DHA relative to the total fatty acids of the residue or to derivatives thereof, wherein the DHA yield is greater than or equal to 60%.Type: ApplicationFiled: November 19, 2010Publication date: May 26, 2011Inventors: Florence MARCIACQ, Mathieu Soulayres, Bernard Freiss
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Patent number: 7906666Abstract: The present invention relates to a continuous process of DHA enrichment of a solution of fatty acids or derivatives thereof comprising less than 50% of DHA relative to the total fatty acids of the solution or to derivatives thereof, wherein the process comprises the steps of (a) simultaneous countercurrent injection, into a fractionation column, of the flow of the solution of fatty acids or of derivatives thereof and of a flow of supercritical CO2 at a temperature of less than or equal to 70° C. and at a pressure of between 100×105 Pa and 160×105 Pa, wherein the level of supercritical CO2 is between 30 and 70, and (b) recovery of the residue comprising at least 50% of DHA relative to the total fatty acids of the residue or to derivatives thereof, wherein the DHA yield is greater than or equal to 60%.Type: GrantFiled: December 19, 2006Date of Patent: March 15, 2011Assignee: Pierre Fabre MedicamentInventors: Florence Marciacq, Mathieu Soulayres, Bernard Freiss
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Patent number: 7749982Abstract: The present invention relates to a complex that includes mequitazine, a cyclodextrin, and an interaction agent wherein the rate of solubilization in water of complexed mequitazine, measured for a 2 g/l mixture of mequitazine in water at 35° C. after 15 minutes of stirring, is greater than 50% at pH 9. The present invention also relates to a method of preparing the aforementioned complex and a pharmaceutical composition of which the complex is a part.Type: GrantFiled: October 19, 2005Date of Patent: July 6, 2010Assignee: Pierre Fabre MedicamentInventors: Bernard Freiss, Hubert Lochard
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Publication number: 20100087392Abstract: The present invention relates to pharmaceutical compositions comprising ibuprofen in the form of an ibuprofen/cyclodextrin/lysine complex having improved pharmacokinetic properties compared with ibuprofen alone, such as a shortened Tmax and an increased Cmax.Type: ApplicationFiled: March 26, 2008Publication date: April 8, 2010Applicant: Pierre Fabre MedicamentInventors: Bernard Freiss, Hubert Lochard
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Publication number: 20090036532Abstract: The present invention relates to a continuous process of DHA enrichment of a solution of fatty acids or derivatives thereof comprising less than 50% of DHA relative to the total fatty acids of the solution or to derivatives thereof, wherein the process comprises the steps of (a) simultaneous countercurrent injection, into a fractionation column, of the flow of the solution of fatty acids or of derivatives thereof and of a flow of supercritical CO2 at a temperature of less than or equal to 70° C. and at a pressure of between 100×105 Pa and 160×105 Pa, wherein the level of supercritical CO2 is between 30 and 70, and (b) recovery of the residue comprising at least 50% of DHA relative to the total fatty acids of the residue or to derivatives thereof, wherein the DHA yield is greater than or equal to 60%.Type: ApplicationFiled: December 19, 2006Publication date: February 5, 2009Inventors: Florence Marciacq, Mathieu Soulayres, Bernard Freiss
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Patent number: 7390411Abstract: The invention concerns a method for preparing compounds for interaction of an active substance hardly soluble in an aqueous medium with a porous support. The invention is characterized in that it comprises the following steps: (a) mixing the active substance generated by supercritical fluid and the specific amount of porous support; (b) carrying out a molecular diffusion step by contacting in static mode a supercritical fluid with the mixture obtained at step (a) for the time required to improve the dissolution in the aqueous medium of the mixture obtained at step (a); (c) washing the interactive compound obtained at step (b) with a supercritical fluid flow; (d) recuperating the particles of the interactive compound thus formed. The invention also concerns a compound obtainable by said method.Type: GrantFiled: October 11, 2002Date of Patent: June 24, 2008Assignee: Pierre Fabre MedicamentInventors: Jacques Fages, Bernard Freiss, Christophe Joussot-Dubien, Jean-Jacques Letourneau, Hubert Lochard, Florence Marciacq, Martial Sauceau
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Publication number: 20070293454Abstract: The present invention relates to a complex that includes mequitazine, a cyclodextrin, and an interaction agent wherein the rate of solubilization in water of complexed mequitazine, measured for a 2 g/l mixture of mequitazine in water at 35° C. after 15 minutes of stirring, is greater than 50% at pH 9. The present invention also relates to a method of preparing the aforementioned complex and a pharmaceutical composition of which the complex is a part.Type: ApplicationFiled: October 19, 2005Publication date: December 20, 2007Inventors: Bernard Freiss, Hubert Lochard
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Publication number: 20070270379Abstract: The invention relates to a method for preparing a soluble inclusion complex comprising one or several active substances which are hardly soluble in an aqueous medium and are included in one or several host molecules, characterised in that it comprises the following succesive stages: (a) one or several active substances are brought into contact with one or several host molecules; (b) initiation of a molecular diffusion stage by bringing a dense pressurized fluid into contact with the mixture obtained in stage (a) in a static mode in the presence of one or several diffusing agents; (c) recovery of the active substance- host molecule molecular complex thus formed; (d) initiation of a stage wherein an interaction agent is added to and mixed with the active substance host molecule molecular complex; (e) recovery of the soluble inclusion compound thus formed.Type: ApplicationFiled: March 29, 2005Publication date: November 22, 2007Applicant: Pierre Fabre MedicamentInventors: Bernard Freiss, Florence Marciacq, Hubert Lochard
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Publication number: 20060246140Abstract: The invention relates to a method for the preparation of soluble molecular complexes, comprising one or more active substances which are poorly-soluble in an aqueous medium, included within one or more host molecules, characterised in comprising the following steps: (a) bringing one or more active substances into contact with one or more host molecules, (b) carrying out a molecular diffusion step by bringing a dense fluid into contact, under pressure, with the mixture obtained in (a), in static mode, in the presence of one or more diffusion agents and (c) recovery of the molecular complex thus formed.Type: ApplicationFiled: April 23, 2004Publication date: November 2, 2006Inventors: Hubert Lochard, Martial Sauceau, Bernard Freiss
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Publication number: 20050274671Abstract: The invention concerns a method for preparing compounds for interaction of an active substance hardly soluble in an aqueous medium with a porous support. The invention is characterized in that it comprises the following steps: (a) mixing the active substance generated by supercritical fluid and the specific amount of porous support; (b) carrying out a molecular diffusion step by contacting in static mode a supercritical fluid with the mixture obtained at step (a) for the time required to improve the dissolution in the aqueous medium of the mixture obtained at step (a); (c) washing the interactive compound obtained at step (b) with a supercritical fluid flow; (d) recuperating the particles of the interactive compound thus formed. The invention also concerns a compound obtainable by said method.Type: ApplicationFiled: October 11, 2002Publication date: December 15, 2005Inventors: Jacques Fages, Bernard Freiss, Christophe Joussot-Dubien, Jean-Jacques Letourneau, Hubert Lochard, Florence Marciacq, Martial Sauceau