Patents by Inventor Bernard G. Huyghe

Bernard G. Huyghe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR THERAPEUTIC USE
    Publication number: 20110104118
    Abstract: A method and pharmaceutical composition for the treatment of cancer using a gene delivery system, such as a viral vector delivery system, comprising a therapeutic gene such as p53 or a retinoblastoma tumor suppressor gene wherein the gene delivery system is formulated in a buffer comprising a delivery-enhancing agent such as ethanol or a detergent.
    Type: Application
    Filed: October 26, 2010
    Publication date: May 5, 2011
    Applicant: Canji, Inc.
    Inventors: Heidrun Engler, Bernard G. Huyghe, Daniel C. Maneval, Paul Shabram
  • COMPOSITIONS AND METHODS FOR THERAPEUTIC USE
    Publication number: 20090048148
    Abstract: A method and pharmaceutical composition for the treatment of cancer using a gene delivery system, such as a viral vector delivery system, comprising a therapeutic gene such as p53 or a retinoblastoma tumor suppressor gene wherein the gene delivery system is formulated in a buffer comprising a delivery-enhancing agent such as ethanol or a detergent.
    Type: Application
    Filed: March 28, 2008
    Publication date: February 19, 2009
    Applicant: Canji, Inc
    Inventors: Heidrun Engler, Bernard G. Huyghe, Daniel C. Maneval, Paul Shabram
  • Compositions and methods for therapeutic use
    Publication number: 20030211598
    Abstract: A method and pharmaceutical composition for the treatment of cancer using a gene delivery system, such as a viral vector delivery system, comprising a therapeutic gene such as p53 or a retinoblastoma tumor suppressor gene wherein the gene delivery system is formulated in a buffer comprising a delivery-enhancing agent such as ethanol or a detergent.
    Type: Application
    Filed: June 3, 2003
    Publication date: November 13, 2003
    Applicant: CANJI, INC.
    Inventors: Heidrun Engler, Bernard G. Huyghe, Daniel C. Maneval, Paul Shabram
  • Compositions and methods for therapeutic use
    Patent number: 6165779
    Abstract: A method and pharmaceutical composition for the treatment of cancer using a gene delivery system, such as a viral vector delivery system, comprising a therapeutic gene such as p53 or a retinoblastoma tumor suppressor gene wherein the gene delivery system is formulated in a buffer comprising a delivery-enhancing agent such as ethanol or a detergent.
    Type: Grant
    Filed: January 7, 1997
    Date of Patent: December 26, 2000
    Assignee: Canji, Inc.
    Inventors: Heidrun Engler, Bernard G. Huyghe, Daniel C. Maneval, Paul Shabram
  • Method of purification of viral vectors
    Patent number: 5837520
    Abstract: The invention provides a method for purifying viral vectors containing therapeutic genes for use in gene therapy. The invention comprises a method of purification from a cell lysate of a recombinant viral vector containing a therapeutic gene, which comprises: a) treating said lysate with an enzymatic agent that selectively degrades both unencapsulated DNA and RNA; b) chromatographing the treated lysate from step a) on a first resin; and c) chromatographing the eluant from step b) on a second resin; wherein one resin is an anion exchange resin and the other is an immobilized metal ion chromatography (IMAC) resin.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: November 17, 1998
    Assignee: Canji, Inc.
    Inventors: Paul W. Shabram, Bernard G. Huyghe, Xiaodong Liu, H. Michael Shepard