Patents by Inventor Bernard J. Graves

Bernard J. Graves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cephalosporin antibiotics
    Patent number: 4501741
    Abstract: 7.beta.-[2-Amino-2-(benzothien-4,5,6, and 7-yl)acetylamino]-3-substituted-3-cepham-4-carboxylic acids and 7.beta.-[2-amino-2-(2,3-dihydrobenzothien-4,5,6, and 7 yl)acetylamino]-3H- or 3-substituted-3-cephem-4-carboxylic acids (1), e.g. 7.beta.-[2-amino-2-(benzothien-4-yl)acetylamino]-3-methyl-3-cephem-4-carbo xylic acid, are orally effective antibiotics. Also provided are benzothienyl oximino compounds, the corresponding 2,3-dihydro compounds (2) useful as intermediates to (1) and as antibiotics, as well as 7.beta.-(2,2-dialkyl-5-oxo-4-benzothienyl-1-imidazolidinyl)-3H-(3-substitu ted)-3-cephem-4-carboxylic acids and the corresponding 2,3-dihydro compounds (3) useful as antibiotics, and prepared with (1) by condensation with ketones. Pharmaceutical formulations of antibiotic compounds (1), (2), and (3) are provided.
    Type: Grant
    Filed: April 12, 1983
    Date of Patent: February 26, 1985
    Assignee: Eli Lilly and Company
    Inventors: Bernard J. Graves, Stjepan Kukolja
  • Benzothienylglycyl cephalosporin derivatives
    Patent number: 4482553
    Abstract: 7-(2-Benzothienyl)glycylamido cephalosporins have good gram positive activity and favorable pharmacokinetics and are orally effective.
    Type: Grant
    Filed: April 12, 1983
    Date of Patent: November 13, 1984
    Assignee: Eli Lilly and Company
    Inventors: Robin D. G. Cooper, Bernard J. Graves, Edward R. Lavagnino