Patents by Inventor Bernard Lamy
Bernard Lamy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11484596Abstract: The present invention discloses a new efficient process for the preparation of the KDR-targeting peptide-phospholipid conjugate of formula (I), which can be useful in therapeutic and diagnostic compositions and particularly in the preparation of ultrasound contrast agents.Type: GrantFiled: December 16, 2019Date of Patent: November 1, 2022Assignee: Bracco Suisse SAInventors: Anthony Clouet, Bernard Lamy
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Publication number: 20220202944Abstract: The present invention discloses a new efficient process for the preparation of the KDR-targeting peptide-phospholipid conjugate of formula (I), which can be useful in therapeutic and diagnostic compositions and particularly in the preparation of ultrasound contrast agents.Type: ApplicationFiled: December 16, 2019Publication date: June 30, 2022Applicant: Bracco Suisse SAInventors: Anthony CLOUET, Bernard LAMY
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Publication number: 20210171854Abstract: The present invention relates to the field of multipurpose lubricants which may be used in the various components of automotive vehicles, notably in the engine, the transmission or the hydraulic circuit. The invention relates to the use of at least one polymer which improves the viscosity index, chosen from hydrogenated copolymers of diene and of aromatic vinyl, in a lubricant composition for decreasing the viscosity of said lubricant composition in the course of the use of said lubricant composition during the lubrication of the various components of an industrial vehicle, notably of a diesel engine industrial vehicle, such as the engine, the gearbox and the hydraulic circuit, said lubricant composition undergoing at least one thermal shear during its use.Type: ApplicationFiled: April 19, 2019Publication date: June 10, 2021Inventors: Stéphane GAVAND, Sophie OPPILLIART, Bernard LAMY
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Publication number: 20160263254Abstract: Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.Type: ApplicationFiled: June 1, 2016Publication date: September 15, 2016Inventors: Philippe BUSSAT, Samir Cherkaoui, Hong Fan, Bernard Lamy, Palaniappa Nanjappan, Radhakrishna K. Pillai, Sibylle Pochon, Bo Song, Rolf E. Swenson
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Patent number: 9381258Abstract: Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.Type: GrantFiled: July 23, 2013Date of Patent: July 5, 2016Assignee: Bracco Suisse S.A.Inventors: Philippe Bussat, Samir Cherkaoui, Hong (Helen) Fan, Bernard Lamy, Palaniappa Nanjappan, Radhakrishna K. Pillai, Sibylle Pochon, Bo Song, Rolf E. Swenson
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Patent number: 9333273Abstract: Gas-filled microvesicles associated with a polypeptide comprising a sequence of amino acids, said sequence exhibiting binding affinity for selectins, particularly p-selectin. The gas-filled microvesicles can be used in ultrasound imaging.Type: GrantFiled: October 30, 2015Date of Patent: May 10, 2016Assignee: BRACCO SUISSE S.A.Inventors: Thierry Bettinger, Philippe Bussat, Samir Cherkaoui, Irene Guilbert-Brigger, Bernard Lamy
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Patent number: 9295737Abstract: Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.Type: GrantFiled: February 26, 2014Date of Patent: March 29, 2016Assignee: BRACCO SUISSE SAInventors: Philippe Bussat, Samir Cherkaoui, Hong (Helen) Fan, Bernard Lamy, Palaniappa Nanjappan, Radhakrishna K. Pillai, Sibylle Pochon, Bo Song, Rolf E. Swenson
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Publication number: 20160074539Abstract: Gas-filled microvesicles associated with a polypeptide comprising a sequence of amino acids, said sequence exhibiting binding affinity for selectins, particularly p-selectin. The gas-filled microvesicles can be used in ultrasound imaging.Type: ApplicationFiled: October 30, 2015Publication date: March 17, 2016Applicant: BRACCO SUISSE S.A.Inventors: Thierry BETTINGER, Philippe BUSSAT, Samir CHERKAOUI, Irene GUILBERT-BRIGGER, Bernard LAMY
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Patent number: 9211348Abstract: Gas-filled microvesicles associated with a polypeptide comprising a sequence of amino acids, said sequence exhibiting binding affinity for selectins, particularly p-selectin. The gas-filled microvesicles can be used in ultrasound imaging.Type: GrantFiled: August 9, 2011Date of Patent: December 15, 2015Assignee: BRACCO SUISSE S.A.Inventors: Thierry Bettinger, Philippe Bussat, Samir Cherkaoui, Irene Guilbert-Brigger, Bernard Lamy
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Publication number: 20140206837Abstract: Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.Type: ApplicationFiled: February 26, 2014Publication date: July 24, 2014Applicant: BRACCO SUISSE SAInventors: Philippe Bussat, Samir Cherkaoui, Hong (Helen) Fan, Bernard Lamy, Palaniappa Nanjappan, Radhakrishna K. Pillai, Sibylle Pochon, Bo Song, Rolf E. Swenson
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Publication number: 20140031520Abstract: Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.Type: ApplicationFiled: July 23, 2013Publication date: January 30, 2014Applicant: Bracco Suisse SAInventors: Philippe BUSSAT, Samir Cherkaoui, Hong (Helen) Fan, Bernard Lamy, Palaniappa Nanjappan, Radhakrishna K. Pillai, Sibylle Pochon, Bo Song, Rolf E. Swenson
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Publication number: 20130266519Abstract: Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.Type: ApplicationFiled: June 10, 2013Publication date: October 10, 2013Inventors: PHILIPPE BUSSAT, SAMIR CHERKAOUI, HONG (HELEN) FAN, BERNARD LAMY, PALANIAPPA NANJAPPAN, RADHAKRISHNA K. PILLAI, SIBYLLE POCHON, BO SONG, ROLF E. SWENSON
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Patent number: 8551450Abstract: Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.Type: GrantFiled: May 19, 2010Date of Patent: October 8, 2013Inventors: Philippe Bussat, Samir Cherkaoui, Hong (Helen) Fan, Bernard Lamy, Palaniappa Nanjappan, Radhakrishna Pillai, Sibylle Pochon, Bo Song, Rolf E. Swenson
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Publication number: 20130156706Abstract: Gas-filled microvesicles associated with a polypeptide comprising a sequence of amino acids, said sequence exhibiting binding affinity for selectins, particularly p-selectin. The gas-filled microvesicles can be used in ultrasound imaging.Type: ApplicationFiled: August 9, 2011Publication date: June 20, 2013Applicant: BRACCO SUISSE S.A.Inventors: Thierry Bettinger, Philippe Bussat, Samir Cherkaoui, Irene Guilbert-Brigger, Bernard Lamy
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Patent number: 8466107Abstract: Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging, etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof.Type: GrantFiled: August 30, 2012Date of Patent: June 18, 2013Assignee: Bracco Imaging SpAInventors: Philippe Bussat, Bernard Lamy, Edmund R. Marinelli, Sibylle Pochon, Bo Song, Rolf E. Swenson
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Publication number: 20120328512Abstract: Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging, etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof.Type: ApplicationFiled: August 30, 2012Publication date: December 27, 2012Applicant: BRACCO IMAGING S.P.A.Inventors: Philippe Bussat, Bernard Lamy, Edmund R. Marinelli, Sibylle Pochon, Bo Song, Rolf E. Swenson
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Patent number: 8293214Abstract: New targeting or therapeutic compounds which can be incorporated into a composition of gas-filled microvesicles. The invention further relates to gas-filled microvesicles for diagnostic and/or therapeutic use comprising said compounds and to their method of use. The new compounds are compounds of formula M-S-T, wherein: M represents a component capable of associating with an envelope of a gas-filled microvesicle; T represents a component comprising a targeting ligand or a therapeutic agent; and S represents a component comprising at least two bissulfone groups.Type: GrantFiled: December 19, 2007Date of Patent: October 23, 2012Assignee: Bracco Suisse S.A.Inventors: Rolf E. Swenson, Philippe Bussat, Bernard Lamy, Sibylle Pochon, Kondareddiar Ramalingam
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Patent number: 8278274Abstract: Fibrin-binding peptides having high binding affinity and excellent physical characteristics compared to previously known fibrin-binding peptides are provided. These fibrin-binding peptides may be conjugated to a detectable label or a therapeutic agent and used to detect and facilitate treatment of pathological conditions associated with the presence of fibrin such as thrombic, angiogenic and neoplastic conditions. These peptides may be used in imaging processes such as MRI, ultrasound and nuclear medicine imaging (e.g. PET, scintigraphic imaging, etc.). The peptides may also be used therapeutically. The present invention also provides processes and methods for making and using such peptides and conjugates thereof.Type: GrantFiled: December 11, 2007Date of Patent: October 2, 2012Assignee: Bracco Imaging SpAInventors: Philippe Bussat, Bernard Lamy, Edmund R. Marinelli, Sibylle Pochon, Bo Song, Rolf E. Swenson
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Publication number: 20110286936Abstract: Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.Type: ApplicationFiled: June 15, 2011Publication date: November 24, 2011Inventors: Philippe BUSSAT, Samir Cherkaoui, Hong (Helen) Fan, Bernard Lamy, Palaniappa Nanjappan, Radhakrishna K. Pillai, Sibylle Pochon, Bo Song, Rolf E. Swenson
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Patent number: 7985402Abstract: Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.Type: GrantFiled: December 11, 2007Date of Patent: July 26, 2011Assignee: Bracco Suisse SAInventors: Philippe Bussat, Samir Cherkaoui, Hong (Helen) Fan, Bernard Lamy, Palaniappa Nanjappan, Radhakrishna K. Pillai, Sibylle Pochon, Bo Song, Rolf E. Swenson