Patents by Inventor Bernard Le Bonniec

Bernard Le Bonniec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Simultaneous monitoring of fibrinogen and haematocrit in whole blood
    Patent number: 9909977
    Abstract: The present invention relates to a method for determining both (a) the haematocrit value and (b) the fibrinogen content in whole blood of an individual in less than 5 minutes, as well as to associated portable apparatus.
    Type: Grant
    Filed: October 15, 2014
    Date of Patent: March 6, 2018
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICAL, ETAT FRANCAIS (MINISTERE DE LA DEFENSE), SERVICE DE SANTE DES ARMEES, ASSITANCE PUBLIQUE—HOPITAUX DE PARIS, UNIVERSITE PARIS DECARTES
    Inventors: Pascale Gaussem, Anne Godier, Isabelle Gouin-Thibault, Bernard Le Bonniec, Anne-Celine Martin, Nyoucha Morravedge, Marc Samama
  • SIMULTANEOUS MONITORING OF FIBRINOGEN AND HAEMATOCRIT IN WHOLE BLOOD
    Publication number: 20160238521
    Abstract: The present invention relates to a method for determining both (a) the haematocrit value and (b) the fibrinogen content in whole blood of an individual in less than 5 minutes, as well as to associated portable apparatus.
    Type: Application
    Filed: October 15, 2014
    Publication date: August 18, 2016
    Inventors: Pascale GAUSSEM, Anne GODIER, Isabelle GOUIN-THIBAULT, Bernard LE BONNIEC, Anne-Celine MARTIN, Nyoucha MORRAVEDGE, Marc SAMAMA
  • Thrombin cleavable factor X analogues
    Patent number: 8168753
    Abstract: The invention relates to factor X analogues containing the thrombin-cleavable sequence Pro-Arg-Ala in place of the-sequence Thr-Arg-Ile of the activation site of native factor X. These factor X analogues can be used to obtain procoagulant medicinal products.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: May 1, 2012
    Assignee: Institut National de la Sante et de la Recherche Medicale
    Inventors: Virginie Louvain, Elsa Bianchini, Pierre-Emmanuel Marque, Claire Calmel-Tareau, Martine Aiach, Bernard Le Bonniec
  • Thrombin-cleavable chimeric proteins
    Patent number: 7589178
    Abstract: The invention relates to chimeric proteins comprising an artificial sequence for cleavage by thrombin, in which the activation peptide is fibrinopeptide A. Preferably, said chimeric proteins are derived from the zymogen of a serine protease such as PC or FX, by replacing the activation peptide of said zymogen with fibrinopeptide A, or a portion thereof, comprising at least amino acids P10 to P1 of said fibrinopeptide.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: September 15, 2009
    Assignee: Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Bernard Le Bonniec, Pierre-Emmanuel Marque, Virginie Louvain, Claire Calmel, Elsa Bianchini, Martine Aiach
  • Thrombin cleavable factor x analogues
    Publication number: 20060148038
    Abstract: The invention relates to factor X analogues containing the thrombin-cleavable sequence Pro-Arg-Ala in place of the-sequence Thr-Arg-Ile of the activation site of native factor X. These factor X analogues can be used to obtain procoagulant medicinal products.
    Type: Application
    Filed: June 30, 2003
    Publication date: July 6, 2006
    Applicant: INST. NAT'L DE LA SANTE ET DE LA RECH. MEDICALE
    Inventors: Virginie Louvain, Elsa Bianchini, Pierre-Emmanuel Marque, Claire Calmel-Tareau, Martine Aiach, Bernard Le Bonniec
  • Thrombin-cleavable chimeric proteins
    Publication number: 20050202527
    Abstract: The invention relates to chimeric proteins comprising an artificial sequence for cleavage by thrombin, in which the activation peptide is fibrinopeptide A. Preferably, said chimeric proteins are derived from the zymogen of a serine protease such as PC or FX, by replacing the activation peptide of said zymogen with fibrinopeptide A, or a portion thereof, comprising at least amino acids P10 to P1 of said fibrinopeptide.
    Type: Application
    Filed: October 18, 2002
    Publication date: September 15, 2005
    Inventors: Bernard Le Bonniec, Pierre-Emmanuel Marque, Virginie Louvain, Claire Calmei, Elsa Bianchini, Martine Aiach