Abstract: The invention relates to the field of medicine and medicinal chemistry, more in particular to the design, manufacture and use of anti-cancer drugs that can be activated by an external stimulus that can be applied in a spatiotemporal fashion. Provided herein is a compound having the chemical structure or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to a binder polymer obtainable by copolymerizing a monomer mixture comprising a vinyl monomer M1 and a butenolide monomer M2, wherein the vinyl monomer M1 is a vinyl ether, a vinyl ester, or a combination thereof, and wherein the butenolide monomer M2 is a 5-alkoxy-2(5H)-furanone. The invention further relates to a coating composition comprising such binder polymer and to a substrate coated with a coating deposited from such coating composition.

Abstract: The invention relates to a radiation-curable coating composition comprising a 5-hydroxy or 5-alkoxy-2(5H)-furanone compound A, a compound B with two or more vinyl ether or vinyl ester groups, wherein the molar ratio of vinyl moieties in compound B and furanone moieties in compound A is at least 0.5, and wherein the coating composition is free of a compound with two or more acryloyl or methacryloyl groups. The invention further relates to a method of coating a substrate comprising applying such coating composition to a substrate and radiation-curing the coating composition to form a cured coating, and to a coated substrate obtainable by such method.

Abstract: The invention relates to the field of medicine and medicinal chemistry, more in particular to the design, manufacture and use of anti-cancer drugs that can be activated by an external stimulus that can be applied in a spatiotemporal fashion. Provided herein is a compound having the chemical structure or a pharmaceutically acceptable salt thereof.

Abstract: The invention relates to a novel class of gelling agents, to a process of preparing said agents, to the use of said agents to prepare gels, and to the gels thus obtained. A gelling agent or thickener according to the invention comprises a core which is functionalized with three amino acid derived groups by means of an amide or urea linkage. It may be used to gelate or thicken numerous solvents.

Abstract: There is provided a targeted bleaching composition comprising an organic substance which forms a complex with a transition metal, the complex catalyzing bleaching of a substrate by a precursor selected from atmospheric oxygen and/or a peroxyl species. The complex is bound to a recognizing portion having a high binding affinity for stains present on fabrics.

Abstract: The invention relates to catalytically bleaching substrates, especially laundry fabrics, with atmospheric oxygen or air. A method of bleaching a substrate is provided that comprises applying to the substrate, in an aqueous medium, a specified ligand from a selected class which forms a complex with a transition metal, the complex catalysing bleaching of the substrate by atmospheric oxygen. Also provided is an aqueous bleaching composition substantially devoid of peroxygen bleach or a peroxy-based or -generating bleach system. Also provided is a method of treating a textile such as a laundry fabric whereby a complex catalyses bleaching of the textile by atmospheric oxygen after the treatment. The catalyst may be used in dry form, or in a liquor that is then dried, such as an aqueous spray-on fabric treatment fluid or a wash liquor for laundry cleaning, or a non-aqueous dry cleaning fluid or spray-on aerosol fluid. The method can confer cleaning benefits to the textile after the treatment.

Abstract: There is provided a targeted bleaching composition comprising an organic substance which forms a complex with a transition metal, the complex catalyzing bleaching of a substrate by a precursor selected from atmospheric oxygen and/or a peroxyl species. The complex is bound to a recognizing portion having a high binding affinity for stains present on fabrics.

Abstract: A detergent bleaching composition is provided comprising a compound inclug a specified pentadentate nitrogen-containing ligand. The compound can activate hydrogen peroxide or peroxyacids and provides favourable stain removal properties, particularly in the presence or iron, manganese or copper ions. In addition, an improved stability in alkaline aqueous environment has been obtained, in particular at the peroxy compound concentrations generally present in the fabric washing liquor.

Abstract: A bleach and oxidation catalyst is provided comprising a catalytically ace iron, manganese or copper complex including a specified pentadentate nitrogen-containing ligand. The metal complex can activate hydrogen peroxide or peroxyacids and provides favourable stain removal properties. In addition, a considerably improved stability of these metal complex compounds in alkaline aqueous environment has been obtained, in particular at the peroxy compound concentrations generally present in the fabric washing liquor.