Abstract: A tetradentate chelating monoquinoline derivative with a structure as shown in formula (I) is able to specifically chelate redox active metal ions like copper ions that are dis-regulated in neurodegenerative diseases (Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis), or copper accumulation disease like Wilson's disease. The binding constants of these derivatives for zinc are 6-10 orders of magnitude below that ones for copper, and these derivatives have a good capability of reducing an oxidative stress. The method for preparing the derivative is simple and the derivatives have good application prospects in manufacturing drugs for neurodegenerative diseases and diseases related to disorder of copper metabolism.

Abstract: A tetradentate chelating monoquinoline derivative with a structure as shown in formula (I) is able to specifically chelate redox active metal ions like copper ions that are dis-regulated in neurodegenerative diseases (Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis), or copper accumulation disease like Wilson's disease. The binding constants of these derivatives for zinc are 6-10 orders of magnitude below that ones for copper, and these derivatives have a good capability of reducing an oxidative stress. The method for preparing the derivative is simple and the derivatives have good application prospects in manufacturing drugs for neurodegenerative diseases and diseases related to disorder of copper metabolism.

Abstract: A process for protecting the external face of an electro-optical device, the external face comprising at least one optical film adhesively bonded to a transparent substrate and set back therefrom, comprises encapsulating the optical element between the substrate and a transparent cover that is substantially the same size as the substrate. The process comprises adhesive bonding of the cover, the adhesive bonding being achieved by depositing uncured adhesive in two steps, namely a first step that is used first to take up the step difference between the substrate and the optical element, and a second step that is used to adhesively bond the protective cover. Smaller respective thicknesses of adhesive shrink in each step and thus, in the end, the total shrinkage is limited and the quality of the product is improved.

Abstract: A process for protecting the external face of an electro-optical device, the external face comprising at least one optical film adhesively bonded to a transparent substrate and set back therefrom, comprises encapsulating the optical element between the substrate and a transparent cover that is substantially the same size as the substrate. The process comprises adhesive bonding of the cover, the adhesive bonding being achieved by depositing uncured adhesive in two steps, namely a first step that is used first to take up the step difference between the substrate and the optical element, and a second step that is used to adhesively bond the protective cover. Smaller respective thicknesses of adhesive shrink in each step and thus, in the end, the total shrinkage is limited and the quality of the product is improved.

Abstract: The invention relates to a method for chelating metal ion and/or dissolving amyloid aggregates, including chelating metal ions and/or dissolving amyloid aggregates with a compound of formula (I):

Abstract: The invention relates to a method for chelating metal ion and/or dissolving amyloid aggregates, including chelating metal ions and/or dissolving amyloid aggregates with a compound of formula (I):

Abstract: An LCD screen comprises an optical stack of at least one optical film against the rear polarizer placed at the rear of the plate of the LCD module. That face of the optical film overlaid against the polarizer is rough. A bead of glue is dispensed over the thickness of the rim of the stack over the whole of its perimeter. Depending on whether or not the polarizer is of the hardened type, the screen is encapsulated in a mechanical structure comprising an outer frame and an inner frame clamping the plate and the rear polarizer or the plate alone, the bead of glue being dispensed in the space between the inner frame and the stack.

Abstract: The invention relates to compounds of general formula (I), to the process for the preparation thereof and to the use thereof as a therapeutic agent.

Abstract: The invention concerns dual molecules corresponding to formula (I): in which: A represents a molecular residue with antimalarial activity of formula (IIa) or (IIIa) or a residue facilitating bioavailability; B represents a cycloalkyl group potentially substituted, or B represents a bi- or tricyclic group capable of being substituted, or B represents 2 cycloalkyl groups linked together through either a single bond or an alkylene chain; m and n represent independently of one another 0, 1 or 2; R5 represents a hydrogen atom, an alkyl, cycloalkyl or C1-3-alkylene-cycloakyl group; Z1 and Z2 represent an alkyl radical, the group Z1+Z2+Ci+Cj representing a mono- or polycyclic structure, with one of the Z1 or Z2 being able to represent a single bond; R1 and R2, identical or different, represent a hydrogen atom or a functional group capable of increasing hydrosolubility; Rx and Ry forming together a cyclic peroxide including 4 to 8 links and including 1 or 2 additional oxygen atoms in the cyclic structure, possibly su

Abstract: The invention relates to dual molecule compounds containing a peroxide derivative, to processes for the synthesis of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment and prevention of malaria comprising administering such compounds and such pharmaceutical compositions.

Abstract: An LCD screen comprises an optical stack of at least one optical film against the rear polarizer placed at the rear of the plate of the LCD module. That face of the optical film overlaid against the polarizer is rough. A bead of glue is dispensed over the thickness of the rim of the stack over the whole of its perimeter. Depending on whether or not the polarizer is of the hardened type, the screen is encapsulated in a mechanical structure comprising an outer frame and an inner frame clamping the plate and the rear polarizer or the plate alone, the bead of glue being dispensed in the space between the inner frame and the stack.

Abstract: The present invention relates to solid supports functionalized with phosphorus-containing dendrimers, to a process for preparing them, to their use for preparing biochips and to the uses of these biochips, in particular for immobilizing molecules of interest, especially biological molecules of interest such as nucleic acids, polypeptides, lipids and proteins.

Abstract: The invention relates to compounds which are orally bioavailable water soluble metalloporphyrins. These compounds, e.g. represented by Structural Formula (I): wherein R1 and R2 are each independently lower alkyl, cycloalkyl, halogen substituted alkyl or substituted or unsubstituted phenyl groups, are synthetic catalytic scavengers of reactive oxygen chemical species. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of use of these compounds for preventing or arresting free radical associated diseases or conditions.

Abstract: The invention relates to compounds of general formula (I), to the process for the preparation thereof and to the use thereof as a therapeutic agent.

Abstract: The present invention relates to solid supports functionalized with phosphorus-containing dendrimers, to a process for preparing them, to their use for preparing biochips and to the uses of these biochips, in particular for immobilizing molecules of interest, especially biological molecules of interest such as nucleic acids, polypeptides, lipids and proteins.

Abstract: The invention relates to dual molecules formed from coupling products complying with the formula wherein A represents a residue of molecule with anti-malarial activity, Y1 and Y2, represent a linear or branched alkylene chain at C1 to C5, or either Y1 or Y2 is absent, U is an amine, amide, sulphonamide, carboxyl, ether or thioether function, said function linking Y1 and Y2, Z1 and Z2, represent a linear arylene or alkylene, or either Z1 or Z2 is absent, or Z1+Z2 together represent a cyclic or polycyclic structure including the junction carbons Ci and Cj, R1 and R2, represent a hydrogen atom or a functional group capable of increasing the hydrosolubility of the dual molecule, Rx and Ry form a cyclic peroxide with 4 to 8 chain links, Cj being one of the peaks of said cyclic peroxide, or -Rx or Ry is a cyclic peroxide with 4 to 8 chain links, which may comprise 1 or 2 additional oxygen atoms in the cyclic structure, and one or more substituents R3, identical or different, at least one R3 representing a hal

Abstract: The present invention relates to solid supports functionalized with phosphorus-containing dendrimers, to a process for preparing them, to their use for preparing biochips and to the uses of these biochips, in particular for immobilizing molecules of interest, especially biological molecules of interest such as nucleic acids, polypeptides, lipids and proteins.

Abstract: The invention relates to the use of nitrogeneous polycyclic derivatives for preparing drugs for treating neurodegenerative diseases,

Abstract: The invention concerns an aminoquinoline-antibiotic hybrid compound of general formula (I): Q—(Y1)p—(U)p—(Y2)p-A: wherein Q represents an aminoquinoline, (Y1)p(U)p—(Y2)p? is an optional spacer and A is an antibiotic residue. The invention enables the antibiotic residue activity to be unexpectedly enhanced.

Abstract: The invention relates to dual molecule compounds containing a peroxide derivative, to processes for the synthesis of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment and prevention of malaria comprising administering such compounds and such pharmaceutical compositions.