Patents by Inventor Bernard N. Violand

Bernard N. Violand has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RAGE Fusion Protein Compositions And Methods Of Use
    Publication number: 20130142792
    Abstract: Disclosed are fusion proteins comprising a RAGE polypeptide, wherein the RAGE polypeptide comprises a fragment of a mammalian wild type RAGE peptide and at least one point mutation in the RAGE polypeptide portion of the fusion protein relative to the wild type RAGE peptide. The point mutation may remove and/or alter a glycosylation site or an enzyme cleavage site. Also disclosed are nucleic acids encoding such proteins as well as methods of using such proteins for treating RAGE-mediated pathologies.
    Type: Application
    Filed: October 19, 2010
    Publication date: June 6, 2013
    Inventors: Jeffrey C. Webster, Gregory T. Bleck, Madan Katragadda, Manoj Rajadhyaksha, Bernard N. Violand, Jo-Ann Wentland, Linda Marie Rothlein
  • Method of producing mouse and human endostatin
    Patent number: 6653098
    Abstract: Methods for producing mouse and human endostatin are disclosed. Methods for refolding and purifying endostatin from inclusion bodies expressed in bacteria and nucleic acids encoding full-length and truncated forms of endostatin are also disclosed.
    Type: Grant
    Filed: January 14, 1999
    Date of Patent: November 25, 2003
    Assignee: G. D. Searle & Co.
    Inventors: Bernard N. Violand, Elizabeth I. Harding
  • Variant somatotropin-encoding DNA
    Patent number: 5130422
    Abstract: Variant somatotropins are described in which the asparagine located in the 95-101 region are replaced by glutamine which somatotropins exhibits enhanced stability.
    Type: Grant
    Filed: August 12, 1991
    Date of Patent: July 14, 1992
    Assignee: Monsanto Company
    Inventors: Gwen G. Krivi, Michael R. Schlittler, Bernard N. Violand
  • Somatotropin variants and their use
    Patent number: 5089473
    Abstract: Variant forms of mammalian somatotropins, particularly bovine and porcine somatotropin, in which the asparagine located between positions 95-101 has been replaced by glutamine exhibit enhanced stability at high pH and at elevated temperatures while retaining bioactivity equivalent to the corresponding unmutated somatotropins, and are useful in the treatment of animals to enhance growth and/or milk production.
    Type: Grant
    Filed: August 29, 1988
    Date of Patent: February 18, 1992
    Assignee: Monsanto Company
    Inventors: Gwen G. Krivi, Michael R. Schlittler, Bernard N. Violand
  • Pharmaceutical preparation containing purified fibronectin
    Patent number: 4478829
    Abstract: Disclosed are readily reconstitutable lyophilized fibronectin formulations containing fibronectin, a neutral salt, a carbohydrate and a surface active agent.
    Type: Grant
    Filed: March 30, 1984
    Date of Patent: October 23, 1984
    Assignee: Armour Pharmaceutical Company
    Inventors: Ricardo H. Landaburu, Robert H. Yue, David L. Farb, Bernard N. Violand