Patents by Inventor Bernard P. Bucher

Bernard P. Bucher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4536580
    Abstract: There are disclosed nor-tropane derivatives substituted at the 3 position with aroylamino or heteroaroylamino and substituted at the 8 position with benzyl, substituted benzyl, 2-methyl thiophene, 3-methyl thiophene, 2-methyl furan or cyclohexylmethyl. The compounds are prepared by condensing the carboxylic acids corresponding to said aroyl or heteroaroyl group with the corresponding .beta.-3-amino-8-substituted nor-tropanes. The compounds possess neuroleptic properties.
    Type: Grant
    Filed: July 19, 1982
    Date of Patent: August 20, 1985
    Assignee: Delalande S.A.
    Inventors: Philippe L. Dostert, Thierry F. Imbert, Bernard P. Bucher
  • Patent number: 4528380
    Abstract: New tetrazole derivatives, characterized in that they correspond to the formula: ##STR1## in which R.sub.1 represents: either a hydrogen atom in any one of the positions 1 to 5 of the tetrazole nucleus, R designating a branched alkyl group comprising at least 5 carbon atoms or a branched alkenyl group, or a methyl group in position 2(3) of the tetrazole nucleus, R representing the (1-propyl)n butyl chain.These new derivatives are useful as medicaments, more especially for their anti-epileptic action.
    Type: Grant
    Filed: December 6, 1982
    Date of Patent: July 9, 1985
    Assignee: Delalande S.A.
    Inventors: Alain P. Lacour, Michel Langlois, Maurice F. Jalfre, Bernard P. Bucher
  • Patent number: 4471120
    Abstract: There are disclosed nor-tropane derivatives substituted at the 3 position with aroylamino or heteroaroylamino and substituted at the 8 position with benzyl, substituted benzyl, 2-methyl thiophene, 3-methyl thiophene, 2-methyl furan or cyclohexylmethyl. The compounds are prepared by condensing the carboxylic acids corresponding to said aroyl or heteroaroyl group with the corresponding .beta.-3-amino-8-substituted nor-tropanes. The compounds possess neuroleptic properties.
    Type: Grant
    Filed: January 7, 1980
    Date of Patent: September 11, 1984
    Assignee: Delalande S.A.
    Inventors: Philippe L. Dostert, Thierry F. Imbert, Bernard P. Bucher
  • Patent number: 4463004
    Abstract: Compounds having analgesic activity are disclosed which have the general formula: ##STR1## wherein R.sub.1 is hydrogen, alkyl having 1 to 4 carbon atoms, cyclohexyl or benzyl; R is selected from the group consisting of alkyl having at least 4 carbon atoms; cyclohexyl; unsubstituted phenyl or phenyl substituted with one or more halogen atoms, methyl, methoxy, hydroxy, cyano, nitro, trifluoromethyl, carboxyl, ethoxycarbonyl, acetamido, methylsulfonyl, phenoxy, benzoyl, phenyl, .alpha.-hydroxybenzyl, cyclohexyl or carbamoyl; thienyl; pyridyl; naphthyl; naphthyl substituted with methoxy; adamantyl; and benzyl; and n is 1, 2 or 3, with the provisos that (1) when R is carboxyphenyl, benzoylphenyl, or (.alpha.-hydroxybenzyl) phenyl, n is not 3, and (2) when R is (.alpha.-hydroxy benzyl) phenyl, R.sub.1 is not benzyl, and acid addition salts thereof.
    Type: Grant
    Filed: April 16, 1982
    Date of Patent: July 31, 1984
    Assignee: Delalande S.A.
    Inventors: Patrick G. Guerret, Bernard P. Bucher, Philippe L. Dostert, Gisele C. Mocquet, Alain L. Nedelec
  • Patent number: 4424358
    Abstract: There are disclosed nor-tropane derivatives substituted at the 3 position with aroylamino or heteroaroylamino and substituted at the 8 position with benzyl, substituted benzyl, 2-methyl thiophene, 3-methyl thiophene, 2-methyl furan or cyclohexylmethyl. The compounds are prepared by condensing the carboxylic acids corresponding to said aroyl or heteroaroyl group with the corresponding .beta.-3-amino-8-substituted nor-tropanes. The compounds possess neuroleptic properties.
    Type: Grant
    Filed: September 11, 1980
    Date of Patent: January 3, 1984
    Assignee: Delalande S.A.
    Inventors: Philippe L. Dostert, Thierry F. Imbert, Bernard P. Bucher
  • Patent number: 4395416
    Abstract: Derivatives of formula: ##STR1## in which Z< represents: either an amino group of struture >N-R.sub.1 where R.sub.1 represents a linear or branched alkyl group with 1 to 5 carbon atoms or a phenyl group possibly substituted by a chlorine atom, in which case:n=1 or 2,the pair (A, C X) assumes the following values: (S, C.dbd.O), (S, CH.sub.2), (O, CH.sub.2), (O, CH--C.sub.6 H.sub.5), andR represents a hydrogen or halogen atom, one or more methoxy groups or the butadiene-1,3 ylene chain ##STR2## fixed in position 5,6 of the phenyhl nucleus and thus forming with this latter a naphthyl nucleus;or a methylene group (--CH.sub.2 --), in which case:n=1 or 2,A represents the oxygen atom,>C X represents a carbonyl group (>C.dbd.O) or thiocarbonyl group (>C.dbd.S), andR has the same meanings as previously,as well as the mineral or organic acid addition salts thereof. The compounds exhibit anti-convulsion and analgesic activity.
    Type: Grant
    Filed: January 21, 1982
    Date of Patent: July 26, 1983
    Assignee: Delalande S.A.
    Inventors: Michel Langlois, Bernard P. Bucher, Philippe L. Dostert, Alain P. Lacour, Gerard H. Moinet
  • Patent number: 4372967
    Abstract: Derivatives of 5H-furanone-2 and 3H-dihydrofuranone-2, substituted at the 3 position with substituted phenyl and at the 5 position with substituted methyl, are prepared by various processes. The derivatives are inhibitors of monoamine oxidase and are useful for treating depression.
    Type: Grant
    Filed: February 26, 1982
    Date of Patent: February 8, 1983
    Assignee: Delalande S.A.
    Inventors: Michel Langlois, Alain P. Lacour, Bernard P. Bucher, Gisele C. Mocquet
  • Patent number: 4346102
    Abstract: Derivatives of 5H-furanone-2 and 3H-dihydrofuranone-2, substituted at the 3 position with substituted phenyl and at the 5 position with substituted methyl, are prepared by various processes. The derivatives are inhibitors of monoamine oxidase and are useful for treating depression.
    Type: Grant
    Filed: April 28, 1980
    Date of Patent: August 24, 1982
    Assignee: Delalande S.A.
    Inventors: Michel Langlois, Alain P. Lacour, Bernard P. Bucher, Gisele C. Mocquet
  • Patent number: 4329466
    Abstract: There are disclosed nor-tropane derivatives substituted at the 3 position with aroylamino or heteroaroylamino and substituted at the 8 position with benzyl, substituted benzyl, 2-methyl thiophene, 3-methyl thiophene, 2-methyl furan or cyclohexylmethyl. The compounds are prepared by condensing the carboxylic acids corresponding to said aroyl or heteroaroyl group with the corresponding .beta.-3-amino-8-substituted nor-tropanes. The compounds possess neuroleptic properties.
    Type: Grant
    Filed: April 16, 1981
    Date of Patent: May 11, 1982
    Assignee: Delalande S.A.
    Inventors: Philippe L. Dostert, Thierry F. Imbert, Bernard P. Bucher
  • Patent number: 4321378
    Abstract: There are disclosed nor-tropane derivatives substituted at the 3 position with aroylamino or heteroaroylamino and substituted at the 8 position with benzyl, substituted benzyl, 2-methyl thiophene, 3-methyl thiophene, 2-methyl furan or cyclohexylmethyl. The compounds are prepared by condensing the carboxylic acids corresponding to said aroyl or heteroaroyl group with the corresponding .beta.-3-amino-8-substituted nor-tropanes. The compounds possess neuroleptic properties.
    Type: Grant
    Filed: April 16, 1981
    Date of Patent: March 23, 1982
    Assignee: Delalande S.A.
    Inventors: Philippe L. Dostert, Thierry F. Imbert, Bernard P. Bucher
  • Patent number: 4250178
    Abstract: Compounds for the formula ##STR1## for example, ##STR2## are prepared by reacting ##STR3## with ##STR4## The compounds possess neuroleptic properties.
    Type: Grant
    Filed: February 12, 1979
    Date of Patent: February 10, 1981
    Assignee: Delalande S.A.
    Inventors: Bernard P. Bucher, Jean-Francois R. Ancher, Thierry F. Imbert