Abstract: The present invention provides piperazine derivatives exhibiting high affinity to the stem region (viral membrane proximal part) of influenza hemagglutinin as determined through competition binding and high virus neutralization activity while having low cytotoxity. Furthermore, the present invention relates to pharmaceutical compositions comprising said piperazine derivatives, methods of preparing said piperazine derivatives, as well as said piperazine derivatives for use in medical prevention or treatment, especially for preventing or treating influenza.

Abstract: The present invention provides piperazine derivatives exhibiting high affinity to the stem region (viral membrane proximal part) of influenza hemagglutinin as determined through competition binding and high virus neutralization activity while having low cytotoxity. Furthermore, the present invention relates to pharmaceutical compositions comprising said piperazine derivatives, methods of preparing said piperazine derivatives, as well as said piperazine derivatives for use in medical prevention or treatment, especially for preventing or treating influenza.

Abstract: The present application relates to a circuit of a frequency divider arranged to divide a frequency of an input clock signal by odd integer N and a method of operating the circuit. A shift register comprises a number of N+1 clock gating cells, which are connected in series to each other, and a shift logic. An input clock signal is fed into clock signal inputs of each one of the number of N+1 clock gating cells. The shift logic is configured to receive enable signals from a set of the number of N+1 clock gating cells and to generate a feedback signal, which is supplied to a gate enable input of the first one of the number of N+1 clock gating cells. A multiplexer is configured to receive at input ports N+1 gated clock signals and to output a rotation clock signal, which has a frequency of 2/N of the frequency of the input clock signal. A frequency generator is configured to receive the rotation clock signal and to generate an output clock signal having a frequency of 1/N.

Abstract: The present application relates to a circuit of a frequency divider arranged to divide a frequency of an input clock signal by odd integer N and a method of operating the circuit. A shift register comprises a number of N+1 clock gating cells, which are connected in series to each other, and a shift logic. An input clock signal is fed into clock signal inputs of each one of the number of N+1 clock gating cells. The shift logic is configured to receive enable signals from a set of the number of N+1 clock gating cells and to generate a feedback signal, which is supplied to a gate enable input of the first one of the number of N+1 clock gating cells. A multiplexer is configured to receive at input ports N+1 gated clock signals and to output a rotation clock signal, which has a frequency of 2/N of the frequency of the input clock signal. A frequency generator is configured to receive the rotation clock signal and to generate an output clock signal having a frequency of 1/N.

Abstract: A differential-logic logic circuit chained with another differential-logic circuit comprises a first logic cell composed of back-gate transistors, the first cell having a first input for receiving a first input signal and having an output for delivering a first output signal, and a second logic cell complementary to the first cell, composed of back-gate transistors, the second cell having as many inputs as the first cell, each input able to receive an input signal complementary to the respective input signal of the first cell, the second cell having an output for delivering a second output signal complementary to the first output signal of the first cell. The first output signal of the first cell is applied to the back gate of each transistor of the second cell, and the second output signal of the second cell is applied to the back gate of each transistor of the first cell.

Abstract: A syringe holder for a motorized injection device, the syringe holder being adapted to receive a receptacle intended to contain a fluid or viscous substance, preferably a disposable refillable receptacle or a syringe, as well as being adapted to be mounted on the motorized injection device such that the motorized injection device enables a part or all of the fluid or viscous substance contained in said receptacle to be expelled. The syringe holder includes a first activator portion to control a predefined function of the motorized injection device. The syringe holder is distinguished in that it comprises a second activator portion to control said predefined function of the motorized injection device independently from the first activator portion.

Abstract: Methods, systems, and apparatus, including computer programs, providing resilient SCTP stack operation. One method includes having a master and slave for a gateway, the master checkpointing key protocol state, including: for transmissions over an SCTP connection from an application to a peer, checkpointing the message payload when a message is received from the application and before it is pushed to the SCTP protocol; after transmitting data to the peer, checkpointing a stream ID, stream sequence number, and transmission sequence number (TSN) of each chunk; and on receiving a selective acknowledgement (SACK) that a chunk was received, deleting the chunk and checkpointing this deletion; and for receptions of data: on receiving a chunk from the peer, checkpointing a message payload, stream ID, stream sequence number, and TSN before sending a SACK; and upon delivery of a message to the application, deleting the message from the SCTP stack and checkpointing the deletion.

Abstract: A current sense circuit for a PWM driver comprises: a PWM control circuit comprising: a first switching device arranged to receive a PWM signal from the PWM driver whose current is to be sensed; and a second switching device whose supply current is arranged to track the sensed current of the PWM driver. An ADC is operably coupled to the first and second switching device. The ADC comprises: a DAC arranged to provide a current sense to the second switching device that tracks the current passing through the PWM driver; a first comparator arranged to receive and compare an output current from the DAC and an output current from the first switching device; and a first successive approximation register arranged to receive an output from the comparator and provide: a first output to the ADC; and a second output that provides a representation of the sensed current.

Abstract: A differential-logic logic circuit chained with another differential-logic circuit comprises a first logic cell composed of back-gate transistors, the first cell having a first input for receiving a first input signal and having an output for delivering a first output signal, and a second logic cell complementary to the first cell, composed of back-gate transistors, the second cell having as many inputs as the first cell, each input able to receive an input signal complementary to the respective input signal of the first cell, the second cell having an output for delivering a second output signal complementary to the first output signal of the first cell. The first output signal of the first cell is applied to the back gate of each transistor of the second cell, and the second output signal of the second cell is applied to the back gate of each transistor of the first cell.

Abstract: A syringe holder for a motorized injection device, the syringe holder being adapted to receive a receptacle intended to contain a fluid or viscous substance, preferably a disposable refillable receptacle or a syringe, as well as being adapted to be mounted on the motorized injection device such that the motorized injection device enables a part or all of the fluid or viscous substance contained in said receptacle to be expelled. The syringe holder includes a first activator portion to control a predefined function of the motorized injection device. The syringe holder is distinguished in that it comprises a second activator portion to control said predefined function of the motorized injection device independently from the first activator portion.

Abstract: Mixed inhibitors of aminopeptidase N and neprilysin are disclosed. Pharmaceutical compositions containing at least one of these compounds, used alone or in combination with morphine and derivatives thereof, endocannabinoids and inhibitors of endocannabinoid metabolism, GABA derivatives such as gabapentin or pregabalin, duloxetine or methadone, can be used as an analgesic, anxiolytic, antidepressant or anti-inflammatory.

Abstract: A current sense circuit for a PWM driver comprises: a PWM control circuit comprising: a first switching device arranged to receive a PWM signal from the PWM driver whose current is to be sensed; and a second switching device whose supply current is arranged to track the sensed current of the PWM driver. An ADC is operably coupled to the first and second switching device. The ADC comprises: a DAC arranged to provide a current sense to the second switching device that tracks the current passing through the PWM driver; a first comparator arranged to receive and compare an output current from the DAC and an output current from the first switching device; and a first successive approximation register arranged to receive an output from the comparator and provide: a first output to the ADC; and a second output that provides a representation of the sensed current.

Abstract: Mixed inhibitors of aminopeptidase N and neprilysin are disclosed. Pharmaceutical compositions containing at least one of these compounds, used alone or in combination with morphine and derivatives thereof, endocannabinoids and inhibitors of endocannabinoid metabolism, GABA derivatives such as gabapentin or pregabalin, duloxetine or methadone, can be used as an analgesic, anxiolytic, antidepressant or anti-inflammatory.

Abstract: A peptide substrate selectively recognisable by a botulinum toxin A, BoNT/A containing a Nop-(Z)-Pya fragment in the peptide structure thereof, wherein Z is an aminoacid chain, preferably RA and the fragment is cleaved by the toxin.

Abstract: The invention is directed to the induction of mitochondrial membrane permeabilization via the physical and functional interaction of the HIV-1 Vpr protein with the mitochondrial inner membrane protein ANT (adenine nucleotide translocator, also called adenine nucleotide translocase or ADP/ATP carrier). Reagents and methods for inducing and/or inhibiting the binding of Vpr to ANT, mitochondrial membrane permeabilization, and apoptosis are provided.

Abstract: A probe for measuring electrical characteristics of an excitation current of a plasma is provided. The probe is mounted on a conductive line that includes an inner conductor and an outer conductor. The probe includes a current sensor and a voltage sensor. The current sensor includes a groove formed in the ground of one of the conductors in order to form a detour for the current flowing through the conductor, and a point for measuring electric voltage between a ground connected to the conductor and a point of the groove. The current sensor thus is able to measure a voltage proportional to the first time derivative of intensity (Iplasma) of the excitation current. The voltage sensor is a shunt sensor capable of measuring a voltage proportional to the first time derivative of the voltage (Vplasma) of the excitation current. A plasma reactor including a probe of the aforementioned type is also provided.

Abstract: The invention relates to derivatives of 4,4?-dithiobis-(3-aminobutane-1-sulfonates) of formula (1), of use for the treatment and prevention of primary and secondary arterial hypertension.

Abstract: The present invention relates to a peptide substrate selectively recognized by botulinum toxin type A, BoNT/A, comprising a Nop-(Z)-Pya fragment in the peptide structure thereof, wherein Z represents an amino acids chain, preferably RA, said fragment being cleaved by said toxin. Said invention also relates to the substrate use, in particular for carrying out methods for detecting, identifying and/or dosing botulinum toxin type A, at very low concentrations (of the order of 20 pg), or inhibitors and/or activators of the metallopeptidase activity of said toxin and thereby making it possible to quantify the power thereof.

Abstract: The present invention relates to nucleic acid sequences encoding novel Babesia canis associated proteins and to cDNA fragments, recombinant DNA molecules and live recombinant carriers comprising these sequences. Furthermore, the invention relates to host cells comprising such nucleic acid sequences, cDNA fragments, recombinant DNA molecules and live recombinant carriers. Also, the invention relates to proteins encoded by these nucleotide sequences, to vaccines for combating Babesia canis infections comprising these proteins or genetic material encoding these proteins and methods for the preparation of vaccines. Another embodiment of the invention relates to these Babesia canis associated proteins for use in vaccines and to the use of the Babesia canis associated proteins in the manufacture of vaccines.

Abstract: The invention relates to a process for separating off maleic anhydride from a gas stream comprising maleic anhydride, in which a) the gas stream comprising maleic anhydride is brought into contact with a liquid absorbent phase comprising at least one high-boiling inert absorption medium for maleic anhydride and b) maleic anhydride is separated off from the resulting liquid absorbate phase by stripping with a hydrogen-comprising gas as stripping medium in a column, wherein the stripping medium is fed in at two points on the column which are at least one theoretical plate apart.