Patents by Inventor Bernard Priem

Bernard Priem has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for in vivo production of glycosaminoglycans
    Patent number: 10301658
    Abstract: The present invention relates to a method for in vivo production of glycosaminoglycans (GAG), by metabolic engineering in a genetically modified cell. In a method according to the invention, said cell is genetically modified in order to express the genes coding for the enzymes that are suitable for synthesizing GAG from an exogenous precursor, preferably internalized by the cell. According to one specific feature, the present invention relates to a method for producing chondroitin or heparosan in a genetically modified bacterial cell, from an exogenous beta-galactoside precursor, preferably internalized by the cell. According to another specific feature, the present invention relates to the use of an Escherichia coli cell comprising at least the genes glcA-T, kfoC, kfiD and wbpP for the production of chondroitin.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: May 28, 2019
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE GRENOBLE ALPES
    Inventor: Bernard Priem
  • METHOD FOR IN VIVO PRODUCTION OF GLYCOSAMINOGLYCANS
    Publication number: 20170137857
    Abstract: The present invention relates to a method for in vivo production of glycosaminoglycans (GAG), by metabolic engineering in a genetically modified cell. In a method according to the invention, said cell is genetically modified in order to express the genes coding for the enzymes that are suitable for synthesising GAG from an exogenous precursor, preferably internalised by the cell. According to one specific feature, the present invention relates to a method for producing chondroitin or heparosan in a genetically modified bacterial cell, from an exogenous beta-galactoside precursor, preferably internalised by the cell. According to another specific feature, the present invention relates to the use of an Escherichia coli cell comprising at least the genes glcA-T, kfoC, kfiD and wbpP for the production of chondroitin.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 18, 2017
    Inventor: Bernard PRIEM
  • Method for producing oligopolysaccharides
    Patent number: 8586332
    Abstract: The invention concerns the production by microbiological process of oligopolysaccharides of biological interest. More particularly, the invention concerns a method for synthesizing in vivo the oligopolysaccharides by internalization of an exogenous precursor in growing bacterial cells expressing adequate modifying and glycosylating genes.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: November 19, 2013
    Assignee: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Eric Samain, Bernard Priem
  • Method for producing oligopolysaccharides
    Patent number: 7521212
    Abstract: The invention concerns the production by microbiological process of oligopolysaccharides of biological interest. More particularly, the invention concerns a method for synthesizing in vivo oligopolysaccharides by internalization of an exogenous precursor in growing bacterial cells expressing adequate modifying and glycosylating genes.
    Type: Grant
    Filed: July 7, 2000
    Date of Patent: April 21, 2009
    Assignee: Centre National de la Recherche Scientifique (CNRS)
    Inventors: Eric Samain, Bernard Priem
  • METHOD FOR PRODUCING OLIGOPOLYSACCHARIDES
    Publication number: 20090082307
    Abstract: The invention concerns the production by microbiological process of oligopolysaccharides of biological interest. More particularly, the invention concerns a method for synthesizing in vivo the oligopolysaccharides by internalization of an exogenous precursor in growing bacterial cells expressing adequate modifying and glycosylating genes.
    Type: Application
    Filed: October 31, 2007
    Publication date: March 26, 2009
    Inventors: Eric Samain, Bernard Priem