Patents by Inventor Bernard R. Neustadt

Bernard R. Neustadt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Angiotensin-converting enzyme inhibitors
    Patent number: 4587258
    Abstract: Novel compounds with angiotensin-converting enzyme inhibitory activity are disclosed. Such compounds are useful in the treatment of cardiovascular disorders, especially hypertension and congestive heart failure, and are useful in the treatment of glaucoma.
    Type: Grant
    Filed: July 30, 1984
    Date of Patent: May 6, 1986
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Bernard R. Neustadt, Elizabeth M. Smith
  • Antihypertensive agents
    Patent number: 4584285
    Abstract: (Benzothiadiazine, benzamido and benzenesulfonyl)phenyl-substituted carboxyalkyl dipeptide compounds are disclosed. Compounds of this invention are useful as antihypertensive agents.
    Type: Grant
    Filed: September 17, 1984
    Date of Patent: April 22, 1986
    Assignee: Schering Corporation
    Inventors: Ronald J. Doll, Bernard R. Neustadt, Elizabeth M. Smith, Charles V. Magatti, Elijah H. Gold
  • Antihypertensive agents
    Patent number: 4559340
    Abstract: There are disclosed benzothiadiazinyl and quinazolinyl substituted carboxylalkyl dipeptides, wherein the benzothiodiazinyl or quinazolinyl portions are joined to the dipeptide portions by an aminocarbonyl group. Compounds of this invention are useful as antihypertensive agents, in the treatment of congestive heart failure and in the treatment of glaucoma. In addition, compounds of this invention have diuretic activity.
    Type: Grant
    Filed: November 25, 1983
    Date of Patent: December 17, 1985
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, David R. Andrews, Paul E. McNamara
  • Tricyclic lactams and derivatives useful in increasing cardiac contractility
    Patent number: 4511569
    Abstract: Disclosed are 5,6-dihydro benzo[f]quinolines and derivatives which are effective in increasing cardiac contractility. These compounds are useful in the treatment of congestive heart failure.
    Type: Grant
    Filed: August 26, 1982
    Date of Patent: April 16, 1985
    Assignee: Schering Corporation
    Inventors: Elizabeth M. Smith, Ronald J. Doll, Bernard R. Neustadt
  • Tricyclic lactams and derivatives useful in increasing cardiac contractility
    Patent number: 4474786
    Abstract: Disclosed are tricyclic lactams and derivatives which are effective in increasing cardiac contractility in humans. These compounds are useful in the treatment of congestive heart failure.
    Type: Grant
    Filed: June 16, 1983
    Date of Patent: October 2, 1984
    Assignee: Schering Corporation
    Inventors: Elizabeth M. Smith, Ronald J. Doll, Bernard R. Neustadt
  • 7-Carboxyalkylaminoacyl-1,4-dithia-7-azaspiro[4.4]-nonane-8-carboxylic acids
    Patent number: 4470972
    Abstract: This invention relates to 7-carboxyalkyl-aminoacyl-1,4-adithia-7-azaspiro[4.4]nonane-8-carboxylic acids. The compounds of the invention are useful in the treatment of cardiovascular disorders and especially as antihypertensive agents.
    Type: Grant
    Filed: December 6, 1982
    Date of Patent: September 11, 1984
    Assignee: Schering Corporation
    Inventors: Elijah H. Gold, Bernard R. Neustadt, Elizabeth M. Smith
  • Arylmethoxy-, arylmethylthio-, heteroarylmethoxy-, and heteroarylmethylthio-alkylaminoalcohols
    Patent number: 4379166
    Abstract: This invention relates to 5-(2-alkylamino-1-hydroxyethyl)salicylamides and 4-(2-alkylamino-1-hydroxyethyl)-2-(methylsulfinyl)phenols wherein the alkyl group is substituted by arylmethoxy, arylmethylthio, heteroarylmethoxy, or heteroarylmethylthio, pharmaceutical compositions thereof, and their use as cardiovascular agents.
    Type: Grant
    Filed: August 3, 1981
    Date of Patent: April 5, 1983
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Elijah H. Gold
  • N-Substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto
    Patent number: 4322434
    Abstract: N-substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto, useful as antihypertensive agents, are prepared by reaction of an N-substituted aniline with a polyfluoroacetone.
    Type: Grant
    Filed: January 22, 1981
    Date of Patent: March 30, 1982
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Elijah H. Gold
  • 2-(Alkylthio, alkylsulfinyl or alkylsulfonyl)-4-[2-anilinoalkylamino)-1-hydroxyethyl]phenols and derivatives thereof
    Patent number: 4304790
    Abstract: 2-(Alkylthio, alkylsulfinyl or alkylsulfonyl)-4-[2-(anilinoalkylamino)-1-hydroxyalkyl]phenols and derivatives thereof, particularly useful as agents for the treatment of hypertension, are disclosed herein.
    Type: Grant
    Filed: June 12, 1979
    Date of Patent: December 8, 1981
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Elijah H. Gold
  • Omega-[4-(polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenoxy and phenylthio]alkanoic acids and compounds related thereto
    Patent number: 4272550
    Abstract: Omega-[4-(polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenoxy and phenylthio]alkanoic acids and compounds related thereto having antihypertensive activity are preparable by reaction of the appropriate 2,3,6-substituted-4-(polyfluoro-2-hydroxy-2-propyl)phenol or thiophenol with an alkyl ester of a bromoalkanoic acid, followed by hydrolysis to the free acid.
    Type: Grant
    Filed: October 31, 1979
    Date of Patent: June 9, 1981
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Elijah H. Gold
  • N-substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto
    Patent number: 4267193
    Abstract: N-substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto, useful as antihypertensive agents, are prepared by reaction of an N-substituted aniline with a polyfluoroacetone.
    Type: Grant
    Filed: May 4, 1979
    Date of Patent: May 12, 1981
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Elijah H. Gold
  • Substituted 4'-polyhaloisopropylsulfonanilides
    Patent number: 4230635
    Abstract: Disclosed are novel substituted 4'-polyhaloisopropylsulfonanilides which are anti-hypertensive agents useful in the treatment of mammalian hypertension. Additionally, the compounds exhibit herbicidal and fungicidal activity. The compounds are prepared by contacting a 4-polyhaloisopropylaniline with the appropriate substituted-sulfonyl chloride.
    Type: Grant
    Filed: August 15, 1978
    Date of Patent: October 28, 1980
    Assignee: Schering Corporation
    Inventor: Bernard R. Neustadt
  • Omega-(4-polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenoxy and phenylthio)alkanoic acids and compounds related thereto
    Patent number: 4199597
    Abstract: Omega-[4-(polyfluoro-2-hydroxy-2-propyl)-2,3,6-substituted-phenoxy and phenylthio]alkanoic acids and compounds related thereto having antihypertensive activity are preparable by reaction of the appropriate 2,3,6-substituted-4-(polyfluoro-2-hydroxy-2-propyl)phenol or thiophenol with an alkyl ester of a bromoalkanoic acid, followed by hydrolysis to the free acid.
    Type: Grant
    Filed: May 4, 1979
    Date of Patent: April 22, 1980
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Elijah H. Gold
  • 2-[4-(Polyhalo-2-hydroxy-2-propyl)anilino]thiazolin-4-ones
    Patent number: 4176120
    Abstract: 2-[4-(Polyhalo-2-hydroxy-2-propyl)anilino]-2-oxazolin-4-ones and the thiazolin-4-ones corresponding thereto, having useful anti-hypertensive properties, are disclosed herein. The compounds are prepared by reaction of the appropriate 4-(polyhalo-2-hydroxy-2-propyl)aniline with a .beta.-chloroethanoyl isocyanate or isothiocyanate and then cyclization of the resultant intermediate.
    Type: Grant
    Filed: April 24, 1978
    Date of Patent: November 27, 1979
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Nicola Zampaglione
  • Anti-hypertensive 5-[2-(substituted anilinoalkylamino)-1-hydroxyalkyl]salicylamides
    Patent number: 4163053
    Abstract: 5-[2-(Substituted-anilinoalkylamino)-1-hydroxyalkyl]-salicylamides, particularly useful as agents for the treatment of hypertension, are disclosed herein.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: July 31, 1979
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Elijah H. Gold
  • Substituted anilino-2-thiazolines
    Patent number: 4159335
    Abstract: Novel para-polyfluoroisopropyl-anilino-2-oxazolines and thiazolines are provided which exhibit potent antihypertensive properties without significant CNS depression.
    Type: Grant
    Filed: January 25, 1978
    Date of Patent: June 26, 1979
    Assignee: Schering Corporation
    Inventor: Bernard R. Neustadt
  • 2-[4-(Polyhalo-2-hydroxy-2-propyl)anilino]-2-oxazolin-4-ones and thiazolin-4-ones corresponding thereto
    Patent number: 4103018
    Abstract: 2-[4-(Polyhalo-2-hydroxy-2-propyl)anilino]-2-oxazolin-4-ones and the thiazolin-4-ones corresponding thereto, having useful anti-hypertensive properties, are disclosed herein. The compounds are prepared by reaction of the appropriate 4-(polyhalo-2-hydroxy-2-propyl)aniline with a .beta.-chloroethanoyl isocyanate or isothiocyanate and then cyclization of the resultant intermediate.
    Type: Grant
    Filed: October 12, 1976
    Date of Patent: July 25, 1978
    Assignee: Schering Corporation
    Inventors: Bernard R. Neustadt, Nicola Zampaglione
  • Anti-hypertensive polyhaloisopropyl-substituted arylureas
    Patent number: 4093742
    Abstract: Novel polyhaloisopropyl-substituted arylureas having potent antihypertensive properties are disclosed herein.
    Type: Grant
    Filed: May 4, 1976
    Date of Patent: June 6, 1978
    Assignee: Schering Corporation
    Inventor: Bernard R. Neustadt
  • Para-polyfluoroisopropyl-anilino-2-oxazoline compounds, pharmaceutical compositions and method of treating hypertension
    Patent number: 4081547
    Abstract: Novel para-polyfluoroisopropyl-anilino-2-oxazolines and thiazolines are provided which exhibit potent antihypertensive properties without significant CNS depression.
    Type: Grant
    Filed: March 19, 1976
    Date of Patent: March 28, 1978
    Assignee: Schering Corporation
    Inventor: Bernard R. Neustadt
  • 6-(Polyhaloisopropyl)quinazoline-2,4-diones
    Patent number: 4058612
    Abstract: Novel 6-(polyhaloisopropyl)quinazoline-2,4-diones, preparable from polyhaloisopropylarylureas, are disclosed herein. These compounds display potent hypotensive activity and are thus useful in the treatment of mammalian hypertension.
    Type: Grant
    Filed: May 20, 1976
    Date of Patent: November 15, 1977
    Assignee: Schering Corporation
    Inventor: Bernard R. Neustadt