Patents by Inventor Bernard Rayner

Bernard Rayner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6124445
    Abstract: Oligonucleotides having bioreversible phosphate blocking groups can be used as pro drugs for the oligonucleotides. The bio-reversible blocking groups can be removed by intercellular enzymes, particularly carboxyesterases, to provide the unprotected oligonucleotide. The oligonucleotides can be prepared via post synthesis alkylation reactions or utilizing amidite type chemistry wherein the bioreversible phosphorus protecting group is formed as an integral part of the amidite reagent.
    Type: Grant
    Filed: January 9, 1998
    Date of Patent: September 26, 2000
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Jean-Louis Imbach, Gilles Gosselin, Bernard Rayner, Muthiah Manoharan
  • Patent number: 5955591
    Abstract: Oligonucleotides having bioreversible phosphate blocking groups can be used as pro drugs for the oligonucleotides. The bio-reversible blocking groups can be removed by intercellular enzymes, particularly carboxyesterases, to provide the unprotected oligonucleotide. The oligonucleotides can be prepared via post synthesis alkylation reactions or utilizing amidite type chemistry wherein the bioreversible phosphorus protecting group is formed as an integral part of the amidite reagent.
    Type: Grant
    Filed: March 13, 1997
    Date of Patent: September 21, 1999
    Inventors: Jean-Louis Imbach, Gilles Gosselin, Bernard Rayner
  • Patent number: 5770713
    Abstract: The trister phosphorothioate oligonucleotides disclosed comprise internucleotide concatenations having a P--S.sup.- bond protected by a bioreversible grouping (X) in intracellular media.
    Type: Grant
    Filed: January 17, 1996
    Date of Patent: June 23, 1998
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jean-Louis Imbach, Bernard Rayner