Patents by Inventor Bernard Roques

Bernard Roques has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210052539
    Abstract: The present invention concerns a pharmaceutically acceptable salt of a compound of the following formula (I): H2N—CH(R1)—CH2S—S—CH2—CH(R2—CONH—CH(R3)—COOR4 (I) and more particularly an acid addition salt thereof, and the compositions comprising the same, for use in the prevention or treatment of trigeminal nerve pain, in particular migraines or trigeminal neuralgia.
    Type: Application
    Filed: January 25, 2019
    Publication date: February 25, 2021
    Inventors: Hervé Poras, Tanja Ouimet, Marie Claude Fournie Zaluski, Bernard Roques, Michel Wurm
  • Patent number: 10131681
    Abstract: The present invention relates to a compound of the following general formula (I): R1—NH—CH(R2)—P(?O)(OR3)—CH2—C(R4)(R5)—CONH—CH(R6)—COOR7 (I) or a pharmaceutically acceptable salt of the latter, an isomer or a mixture of isomers in any proportions, especially a mixture of enantiomers, and in particular a racemic mixture, for which R1 represents a —C(?O)—O—C(R8)(R9)—OC(?O)—R10 group; R2 represents an optionally substituted hydrocarbon-based chain, an aryl or heteroaryl group or a methylene group substituted by a heterocycle; R3 represents a hydrogen atom or a —C(R12)(R13)—OC(?O)—R14 group; R4 and R5 form, together with the carbon that bears them, a saturated hydrocarbon-based ring or an optionally substituted piperidine ring or R4 represents a hydrogen atom and R5 represents a phenyl or a benzyl that is optionally substituted, a heteroaromatic ring or a methylene group substituted by a heterocycle; R6 represents an optionally substituted hydrocarbon-based chain or a phenyl or a benzyl that is optionally substi
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: November 20, 2018
    Assignee: PHARMALEADS
    Inventors: Bernard Roques, Herve Poras, Marie-Claude Fournie-Zaluski
  • Publication number: 20160206762
    Abstract: The present invention is directed to the use of an irreversible ligand of a serine protease selected from the group consisting of leukocyte elastase, thrombin, tissue plasminogen activator (t-PA) and plasmin for the molecular imaging of said serine protease and the diagnosis of pathophysiological conditions associated with said serine protease activity.
    Type: Application
    Filed: January 20, 2016
    Publication date: July 21, 2016
    Applicants: Institut National de la Sante et de la Recherche Medicale, Pharmaleads, Assistance Publique Hopitaux de Paris, Universite Paris Diderot - Paris 7
    Inventors: Jean-Baptiste Michel, Francois Rouzet, Dominique Leguludec, Herve Poras, Marie-Claude Fournie-Zaluski, Bernard Roques
  • Publication number: 20140161839
    Abstract: The present invention relates to a compound of the following general formula (I): R1—NH—CH(R2)—P(?O)(OR3)—CH2—C(R4)(R5)—CONH—CH(R6)—COOR7 (I) or a pharmaceutically acceptable salt of the latter, an isomer or a mixture of isomers in any proportions, especially a mixture of enantiomers, and in particular a racemic mixture, for which R1 represents a —C(?O)—O—C(R8)(R9)—OC(?O)—R10 group; R2 represents an optionally substituted hydrocarbon-based chain, an aryl or heteroaryl group or a methylene group substituted by a heterocycle; R3 represents a hydrogen atom or a —C(R12)(R13)—OC(?O)—R14 group; R4 and R5 form, together with the carbon that bears them, a saturated hydrocarbon-based ring or an optionally substituted piperidine ring or R4 represents a hydrogen atom and R5 represents a phenyl or a benzyl that is optionally substituted, a heteroaromatic ring or a methylene group substituted by a heterocycle; R6 represents an optionally substituted hydrocarbon-based chain or a phenyl or a benzyl that is optionally substi
    Type: Application
    Filed: February 18, 2014
    Publication date: June 12, 2014
    Applicant: PHARMALEADS
    Inventors: Bernard Roques, Herve Poras, Marie-Claude Fournie-Zaluski
  • Patent number: 8703747
    Abstract: The present invention relates to a compound of the following general formula (I): R1—NH—CH(R2)—P(?O)(OR3)—CH2—C(R4)(R5)—CONH—CH(R6)—COOR7 (I) or a pharmaceutically acceptable salt of the latter, an isomer or a mixture of isomers in any proportions, especially a mixture of enantiomers, and in particular a racemic mixture, for which R1 represents a —C(?O)—O—C(R8)(R9)—OC(?O)—R10 group; R2 represents an optionally substituted hydrocarbon-based chain, an aryl or heteroaryl group or a methylene group substituted by a heterocycle; R3 represents a hydrogen atom or a —C(R12)(R13)—OC(?O)—R14 group; R4 and R5 form, together with the carbon that bears them, a saturated hydrocarbon-based ring or an optionally substituted piperidine ring or R4 represents a hydrogen atom and R5 represents a phenyl or a benzyl that is optionally substituted, a heteroaromatic ring or a methylene group substituted by a heterocycle; R6 represents an optionally substituted hydrocarbon-based chain or a phenyl or a benzyl that is optionally substi
    Type: Grant
    Filed: July 22, 2009
    Date of Patent: April 22, 2014
    Assignee: Pharmaleads
    Inventors: Bernard Roques, Hervé Poras, Marie-Claude Fournie-Zaluski
  • Publication number: 20130243691
    Abstract: The present invention is directed to the use of an irreversible ligand of a serine protease selected from the group consisting of leukocyte elastase, thrombin, tissue plasminogen activator (t-PA) and plasmin for the molecular imaging of said serine protease and the diagnosis of pathophysiological conditions associated with said serine protease activity.
    Type: Application
    Filed: December 5, 2011
    Publication date: September 19, 2013
    Applicant: PHARMALEADS
    Inventors: Jean-Baptiste Michel, François Rouzet, Dominique Leguludec, Hervé Poras, Marie-Claude Fournie-Zaluski, Bernard Roques
  • Patent number: 8466309
    Abstract: The disclosure relates to novel compounds of the formula (I) R1NH—CH(R2)CH2—S—S—CH2—C(R3)(R4)—CONH—C(R5)(R6)—COOR7, in which R1 is a (acyloxy)alkyl carbamate-C(O)—O—C(R8)(R9)—OC(O)—R10 group; R2 is a hydrocarbon chain, a methylene radical substituted by a heterocycle, R4 is a hydrogen atom and R3 is a phenyl or benzyl radical, a heteroaryl, a methylene group substituted by a heterocycle or R3 and R4 form together a saturated cycle; R5 and R6 are hydrogen, a hydrocarbon chain, a phenyl or benzyl radical or R5 and R6 form together a saturated cycle; R7 is hydrogen, a phenyl or benzyl radical, a group of the formula CR12(R13)C(O)OR14 or OCR12(R13)OC(O)R14 or OCR12(R13)OC(O)OR14. The disclosure also relates to the use of these compounds as a drug, and to a pharmaceutical composition containing said compounds and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: June 18, 2013
    Inventors: Marie-Claude Fournie-Zaluski, Hervé Poras, Bernard Roques
  • Patent number: 8247608
    Abstract: The invention relates to novel compounds of formula (I): H2N—CH(R1)—CH2—S—S—CH2—CH(R2)—CONH—R5, wherein R1 is a hydrocarbon chain, phenyl or benzyl radical, methylene radical substituted by a 5 or 6 atom heterocycle; R2 is a phenyl or benzyl radical, a 5 or 6 atom aromatic heterocycle, methylene group substituted by a 5 or 6 atom heterocycle; R5 is a CH(R3)—COOR4 radical, wherein R3 is hydrogen, an OH or OR group, a saturated hydrocarbon group, a phenyl or benzyl radical and OR4 is hydrophile ester, or 5 or 6 membered heterocycle comprising several heteroatoms selected from a group consisting of nitrogen, sulphur and oxygen, with at least two nitrogene atoms, wherein said heterocycle is substitutable by an alkyl C1-C6, phenyl or benzyl radical.
    Type: Grant
    Filed: October 24, 2006
    Date of Patent: August 21, 2012
    Assignee: Pharmaleads
    Inventors: Bernard Roques, Marie-Claude Fournie-Zaluski
  • Patent number: 8247609
    Abstract: The invention relates to novel compounds of formula (I): H2N—CH(R1)—CH2—S—S—CH2—CH(R2)—CONH—R5, wherein R1 is a hydrocarbon chain, phenyl or benzyl radical, methylene radical substituted by a 5 or 6 atom heterocycle; R2 is a phenyl or benzyl radical, a 5 or 6 atom aromatic heterocycle, methylene group substituted by a 5 or 6 atom heterocycle; R5 is a CH(R3)—COOR4 radical, wherein R3 is hydrogen, an OH or OR group, a saturated hydrocarbon group, a phenyl or benzyl radical and OR4 is hydrophile ester, or 5 or 6 membered heterocycle comprising several heteroatoms selected from a group consisting of nitrogen, sulphur and oxygen, with at least two nitrogene atoms, wherein said heterocycle is substitutable by an alkyl C1-C6, phenyl or benzyl radical.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: August 21, 2012
    Assignee: Pharamleads
    Inventors: Bernard Roques, Marie-Claude Fournie-Zaluski
  • Patent number: 7971796
    Abstract: The control device for conserving energy for heating water contained in a water heater (30) comprises an electronic detection device (21) for measuring the quantity of hot water remaining in the tank (2), the electronic detection device (21) consisting of a capillary tube (10) containing a heat transfer fluid and an amplification device (15) placed outside the tank (2) of the water heater (30) and connected to an electronic control card (26), the amplification device (15) being suitable for transmitting a variation in resistance to the electronic control card (26) under the effect of the expansion of the fluid contained in the capillary tube (10) and control means (50) connected to the electronic control card (26) for determining the hot water consumption profile of the users in order to control the period or periods of resumption of the heating of the water in the tank (2).
    Type: Grant
    Filed: July 21, 2008
    Date of Patent: July 5, 2011
    Assignee: Cotherm
    Inventor: Bernard Roques
  • Publication number: 20110124601
    Abstract: The present invention relates to a compound of the following general formula (I): R1—NH—CH(R2)—P(?O)(OR3)—CH2—C(R4)(R5)—CONH—CH(R6)—COOR7 (I) or a pharmaceutically acceptable salt of the latter, an isomer or a mixture of isomers in any proportions, especially a mixture of enantiomers, and in particular a racemic mixture, for which R1 represents a —C(?O)—O—C(R8)(R9)—OC(?O)—R10 group; R2 represents an optionally substituted hydrocarbon-based chain, an aryl or heteroaryl group or a methylene group substituted by a heterocycle; R3 represents a hydrogen atom or a —C(R12)(R13)—OC(?O)—R14 group; R4 and R5 form, together with the carbon that bears them, a saturated hydrocarbon-based ring or an optionally substituted piperidine ring or R4 represents a hydrogen atom and R5 represents a phenyl or a benzyl that is optionally substituted, a heteroaromatic ring or a methylene group substituted by a heterocycle; R6 represents an optionally substituted hydrocarbon-based chain or a phenyl or a benzyl that is optionally substi
    Type: Application
    Filed: July 22, 2009
    Publication date: May 26, 2011
    Inventors: Bernard Roques, Hervé Poras, Marie-Claude Fournie-Zaluski
  • Patent number: 7930937
    Abstract: The detection device for measuring the quantity of hot water remaining inside a storage reservoir and more particularly inside a tank (2) of a water heater (3, 30), comprises a capillary tube (10) containing a heat-carrying fluid which is placed either inside, or outside the tank (2) of the water heater (3, 30) and an indicator device (12) coupled to said capillary tube (10), said indicator device (12) comprising an amplifying device (15) disposed outside said tank (2) and making it possible to transmit under the effect of the expansion of the fluid contained in the capillary tube (10) either a motion to a member (16), or a variation in resistance to an electronic measurement card (24) in such a way as to continuously indicate the quantity of hot water available remaining in the tank (2) of the water heater (3, 30).
    Type: Grant
    Filed: July 8, 2008
    Date of Patent: April 26, 2011
    Assignee: Cotherm
    Inventors: Bernard Roques, Jean-Marc Riondy
  • Publication number: 20110071218
    Abstract: The disclosure relates to novel compounds of the formula (I) R1NH—CH(R2)CH2—S—S—CH2—C(R3)(R4)—CONH—C(R5)(R6)—COOR7, in which R1 is a (acyloxy)alkyl carbamate-C(O)—O—C(R8)(R9)—OC(O)—R10 group; R2 is a hydrocarbon chain, a methylene radical substituted by a heterocycle, R4 is a hydrogen atom and R3 is a phenyl or benzyl radical, a heteroaryl, a methylene group substituted by a heterocycle or R3 and R4 form together a saturated cycle; R5 and R6 are hydrogen, a hydrocarbon chain, a phenyl or benzyl radical or R5 and R6 form together a saturated cycle; R7 is hydrogen, a phenyl or benzyl radical, a group of the formula CR12(R13)C(O)OR14 or OCR12(R13)OC(O)R14 or OCR12(R13)OC(O)OR14. The disclosure also relates to the use of these compounds as a drug, and to a pharmaceutical composition containing said compounds and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: May 13, 2009
    Publication date: March 24, 2011
    Applicant: PHARMALEADS
    Inventors: Marie-Claude Fournie-Zaluski, Hervé Poras, Bernard Roques
  • Publication number: 20090131509
    Abstract: The invention relates to novel compounds of formula (I): H2N—CH(R1)—CH2—S—S—CH2—CH(R2)—COONH—R5, wherein R1 is a hydrocarbon chain, phenyl or benzyl radical, methylene radical substituted by a 5 or 6 atom heterocycle; R2 is a phenyl or benzyl radical, a 5 or 6 atom aromatic heterocycle, methylene group substituted by a 5 or 6 atom heterocycle; R5 is a CH(R3)—COOR4 radical, wherein R3 is hydrogen, an OH or OR group, a saturated hydrocarbon group, a phenyl or benzyl radical and OR4 is hydrophile ester, or 5 or 6 membered heterocycle comprising several heteroatoms selected from a group consisting of nitrogen, sulphur and oxygen, with at least two nitrogene atoms, wherein said heterocycle is substitutable by an alkyl C1-C6, phenyl or benzyl radical.
    Type: Application
    Filed: October 24, 2006
    Publication date: May 21, 2009
    Applicant: PHARMALEADS
    Inventors: Bernard Roques, Marie-Claude Fournie-Zaluski
  • Publication number: 20090090788
    Abstract: A control device for conserving energy for heating water contained in a water heater (30) includes: an electronic detection device (21) for measuring the quantity of hot water remaining in the tank (2), the electronic detection device (21) including a capillary tube (10) containing a heat transfer fluid and an amplification device (15) placed outside the tank (2) of the water heater (30) and connected to an electronic control card (26), the amplification device (15) being suitable for transmitting a variation in resistance to the electronic control card (26) under the effect of the expansion of the fluid contained in the capillary tube (10), and control elements (50) connected to the electronic control card (26) for determining the hot water consumption profile of the users in order to control the period or periods of resumption of the heating of the water in the tank (2).
    Type: Application
    Filed: July 21, 2008
    Publication date: April 9, 2009
    Applicant: COTHERM
    Inventor: Bernard ROQUES
  • Publication number: 20090019931
    Abstract: The detection device for measuring the quantity of hot water remaining inside a storage reservoir and more particularly inside a tank (2) of a water heater (3, 30), comprises a capillary tube (10) containing a heat-carrying fluid which is placed either inside, or outside the tank (2) of the water heater (3, 30) and an indicator device (12) coupled to said capillary tube (10), said indicator device (12) comprising an amplifying device (15) disposed outside said tank (2) and making it possible to transmit under the effect of the expansion of the fluid contained in the capillary tube (10) either a motion to a member (16), or a variation in resistance to an electronic measurement card (24) in such a way as to continuously indicate the quantity of hot water available remaining in the tank (2) of the water heater (3, 30).
    Type: Application
    Filed: July 8, 2008
    Publication date: January 22, 2009
    Applicant: COTHERM
    Inventors: Bernard ROQUES, Jean-Marc RIONDY
  • Publication number: 20090012153
    Abstract: The invention relates to novel compounds of formula (I): H2N—CH(R1)—CH2—S—S—CH2—CH(R2)—CONH—R5, wherein R1 is a hydrocarbon chain, phenyl or benzyl radical, methylene radical substituted by a 5 or 6 atom heterocycle; R2 is a phenyl or benzyl radical, a 5 or 6 atom aromatic heterocycle, methylene group substituted by a 5 or 6 atom heterocycle; R5 is a CH(R3)—COOR4 radical, wherein R3 is hydrogen, an OH or OR group, a saturated hydrocarbon group, a phenyl or benzyl radical and OR4 is hydrophile ester, or 5 or 6 membered heterocycle comprising several heteroatoms selected from a group consisting of nitrogen, sulphur and oxygen, with at least two nitrogene atoms, wherein said heterocycle is substitutable by an alkyl C1-C6, phenyl or benzyl radical.
    Type: Application
    Filed: June 26, 2008
    Publication date: January 8, 2009
    Applicant: Pharmaleads
    Inventors: Bernard Roques, Marie-Claude Fournie-Zaluski
  • Publication number: 20080230617
    Abstract: The safety and control device for a domestic electrical appliance according to the present invention comprises an electronic card (2) which comprises an insulating plate (4) comprising a printed circuit (15) supplying an electronic control system (5) for driving a domestic electrical appliance and an electromechanical safety device (3) connected to the printed circuit (15) and comprising an insulating body (8) joined to a capillary or to a safety bimetallic disk (9).
    Type: Application
    Filed: March 21, 2008
    Publication date: September 25, 2008
    Applicant: COTHERM SA
    Inventor: Bernard Roques
  • Patent number: 7381276
    Abstract: An apparatus for holding a semiconductor substrate comprises a plate having a pocket which holds the substrate, wherein the pocket comprises a lower surface and an inner edge. The inner edge comprises a plurality of members extending radially inward to reduce the area of contact between the inner edge and the substrate. The beveled edge is inclined so that there is an acute angle between the lower surface of the pocket and the beveled edge.
    Type: Grant
    Filed: July 16, 2002
    Date of Patent: June 3, 2008
    Assignee: International Business Machines Corporation
    Inventors: Donna K. Johnson, Jim S. Nakos, Jean-Jacques H. Psaute, Bernard A. Roque, Jr.
  • Patent number: 7205435
    Abstract: Novel compounds of general formula (I), are provided with inhibitory properties for the type B botulism toxin activity, along with methods for preparation thereof and corresponding pharmaceutical compositions.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: April 17, 2007
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Centre National de la Recherche Scientifique (C.N.R.C.)
    Inventors: Bernard Roques, Christine Anne, Serge Turcaud, Marie-Claude Fournie-Zaluski