Patents by Inventor Bernard Silverman

Bernard Silverman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200345718
    Abstract: The instant application relates to morphinan derivatives of Formula I with sustained effectiveness in treating drug toxicity and overdose:
    Type: Application
    Filed: February 7, 2020
    Publication date: November 5, 2020
    Inventors: Bernard Silverman, Fen-Ni Fu, Chengyun Guo
  • Patent number: 10046052
    Abstract: Methods and dosage formulations for the safe treatment of cold, cough, flu, and sinus symptoms in children and adolescents by age and nature of symptoms, and adults and the elderly by age, nature of symptoms, and concomitant patient medical conditions. The method of the present invention comprises the formulation of a cold medication which consists essentially of combinations of a nonsedating or minimally sedating antihistamines with pain relievers and the expectorant, guaifenesin.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: August 14, 2018
    Inventor: Bernard Silverman
  • Publication number: 20170333422
    Abstract: The instant application relates to morphinan derivatives of Formula I with sustained effectiveness in treating drug toxicity and overdose:
    Type: Application
    Filed: June 5, 2017
    Publication date: November 23, 2017
    Inventors: Bernard Silverman, Fen-Ni Fu, Chengyun Guo
  • Publication number: 20160051535
    Abstract: The instant application relates to morphinan derivatives of Formula I with sustained effectiveness in treating drug toxicity and overdose:
    Type: Application
    Filed: August 25, 2015
    Publication date: February 25, 2016
    Inventors: Bernard Silverman, Fen-Ni Fu, Chengyun Guo
  • Patent number: 9119848
    Abstract: The instant application relates to morphinan derivatives of Formula I with sustained effectiveness in treating drug toxicity and overdose:
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: September 1, 2015
    Assignee: Alkermes Pharma Ireland Limited
    Inventors: Bernard Silverman, Fen-Ni Fu, Chengyun Guo
  • Publication number: 20120245193
    Abstract: The present invention relates to a novel functional peripherally-acting ? opioid receptor antagonist of Formula I: The novel compounds of the present invention have reduced oral bioavailability without compromising opiate-induced analgesia in the CNS. The compounds of the present invention are further efficacious at low doses and are useful in treating gastrointestinal conditions associated with opioid analgesic therapy.
    Type: Application
    Filed: February 14, 2012
    Publication date: September 27, 2012
    Inventors: Bernard Silverman, Mark Todtenkopf, Daniel Deaver, Lauren DiPetrillo
  • Publication number: 20110281892
    Abstract: Methods and dosage formulations for the safe treatment of cold, cough, flu, and sinus symptoms in children and adolescents by age and nature of symptoms, and adults and the elderly by age, nature of symptoms, and concomitant patient medical conditions. The method of the present invention comprises the formulation of a cold medication which consists essentially of combinations of a nonsedating or minimally sedating antihistamines with pain relievers and the expectorant, guaifenesin.
    Type: Application
    Filed: May 16, 2011
    Publication date: November 17, 2011
    Inventor: Bernard Silverman
  • Publication number: 20110136848
    Abstract: The instant application relates to morphinan derivatives of Formula I with sustained effectiveness in treating drug toxicity and overdose:
    Type: Application
    Filed: October 13, 2010
    Publication date: June 9, 2011
    Inventor: Bernard Silverman
  • Patent number: 5411795
    Abstract: A method for electroless deposition of metal onto a nonconductive surface of a substrate is disclosed. According to the method, the surface is contacted with a nonaqueous carrier polymer mixture comprising (a) an organic solvent, (b) a catalytic compound that is soluble in the solvent and contains a catalytic metal, and (c) a polymer or polymeric precursor that is soluble in the solvent and that can be formed into a polymeric film that retains its integrity at 200.degree. C. Excess solvent is removed from the surface to form a catalytic carrier polymer coating on the surface, the coating comprising catalytic compound adhered to a layer of carrier polymer adhered to the surface. The coating is activated to produce an activated catalytic carrier polymer coating on the surface, which is then contacted with an aqueous electroless plating mixture thereby to form a plated substrate having a film of metal over and adhered to the layer of carrier polymer.
    Type: Grant
    Filed: October 14, 1992
    Date of Patent: May 2, 1995
    Assignee: Monsanto Company
    Inventor: Bernard Silverman
  • Patent number: 5405842
    Abstract: A method for the treatment of asthma, particularly corticosteroid dependent asthma with "steroid sparing" effect, but without serious toxicities prevalent with common "steroid sparing" treatments and medications, comprising the oral administration, in efficacious doses, of sulfasalazine (SSZ) (5-([p-(2-pyridylsulfamoyl) phenyl]azo) salicylic acid) ##STR1## compounds having either the: ##STR2## moiety, or the: ##STR3## moiety. The SSZ and related compounds can be used as an adjuvant for corticosteroid treatments, which permits drastic reduction of the dosage levels of the corticosteroids with concomitant reduction of steroid side effects.
    Type: Grant
    Filed: January 28, 1994
    Date of Patent: April 11, 1995
    Inventor: Bernard A. Silverman
  • Patent number: 4694039
    Abstract: Unsaturated oligomers and solutions thereof are stabilized with a trisubstituted urea to provide improved storage stability. The stabilized unsaturated oligomer solutions are useful in lactam polymerization processes which yield nylon block copolymers containing unsaturated oligomer segments. The unsaturated oligomers disclosed herein have at least 4 carbons and have pendant thereto at least one hydroxy, amine, epoxy, acyllactam, or acyllactam precursor group.
    Type: Grant
    Filed: November 6, 1986
    Date of Patent: September 15, 1987
    Assignee: DSM Rim Nylon V.O.F.
    Inventors: Edward H. Mottus, Ross M. Hedrick, Bernard Silverman
  • Patent number: 4672085
    Abstract: Unsaturated oligomers and solutions thereof are stabilized with a trisubstituted urea to provide improved storage stability. The stabilized unsaturated oligomer solutions are useful in lactam polymerization processes which yield nylon block copolymers containing unsaturated oligomer segments. The unsaturated oligomers disclosed herein have at least 4 carbons and have pendant thereto at least one hydroxy, amine, epoxy, acyllactam, or acyllactam precursor group.
    Type: Grant
    Filed: March 26, 1986
    Date of Patent: June 9, 1987
    Assignee: DSM Rim Nylon VOF
    Inventors: Edward H. Mottus, Ross M. Hedrick, Bernard Silverman
  • Patent number: 4396452
    Abstract: Nonwoven point-bonded fabrics of improved softness are prepared by simultaneously heating and compressing spaced, discrete areas of a nonwoven, bondable fiber web containing an attenuating bonding liquid in excess of the minimum amount required to provide maximum fabric strength.
    Type: Grant
    Filed: December 21, 1978
    Date of Patent: August 2, 1983
    Assignee: Monsanto Company
    Inventors: Virginia C. Menikheim, Bernard Silverman
  • Patent number: 4306929
    Abstract: Nonwoven point-bonded fabrics of improved softness are prepared by simultaneously heating and compressing spaced, discrete areas of a nonwoven thermally bondable fiber web containing an attenuating liquid.
    Type: Grant
    Filed: December 1, 1980
    Date of Patent: December 22, 1981
    Assignee: Monsanto Company
    Inventors: Virginia C. Menikheim, Bernard Silverman
  • Patent number: 4168195
    Abstract: The method of autogenously bonding a nonwoven web made from polyamide filaments wherein the filaments contain 0.1 to 20 weight percent of an activating agent and sufficient moisture that the molar ratio of water to activating agent in the filaments is above the bonding limit, wherein the web is heated sufficiently to drive off enough water to reduce the molar ratio of water to agent to a value below the bonding limit and pressed to autogenously bond the filaments in the web. After pressing, the activating agent is desorbed from the web.
    Type: Grant
    Filed: September 1, 1977
    Date of Patent: September 18, 1979
    Assignee: Monsanto Company
    Inventors: Richard M. Anderson, Alton L. Caviness, Virginia C. Menikheim, Bernard Silverman
  • Patent number: 4164600
    Abstract: Melt blended fibers of lactam-polyol-polyacyl lactam or acyl polylactam terpolymers together with polyesters are thermally bonded at temperatures below the bonding temperatures of either the crystalline polyester or the terpolymer, resulting in thermally stable fabrics that have bond strength greater than the individual polyester or terpolymer webs bonded at the same temperature.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: August 14, 1979
    Assignee: Monsanto Company
    Inventors: Kai-Lim W. Yung, Bernard Silverman, Virginia C. Menikheim
  • Patent number: 4163819
    Abstract: The present invention relates to non-woven fabrics characterized by excellent drapeability, very pleasant handle and good tensile properties. The fabrics are made from melt blends of a polyamide together with lactam-polyol-polyacyl lactam or acyl-polylactam terpolymers.The production of the non-woven webs or fabrics from melt blended fibers of polyamide with lactam-polyol-polyacyl lactam or acyl-polylactam terpolymers is achieved by contact or thermal bonding of melt spun fibers. In one embodiment of the invention, the webs are formed from fibers in the nascent condition as freshly extruded, e.g., they are substantially amorphous. Such amorphous fibers are readily bonded even at room temperature, resulting in autogenous self-bonding, with only little pressure being imposed. If desired these fibers may be bonded at temperatures of up to 210.degree. C.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: August 7, 1979
    Assignee: Monsanto Company
    Inventors: Kai-Lim W. Yung, Bernard Silverman
  • Patent number: 4148960
    Abstract: Melt blended shaped objects, fibers and fabrics of polyesters with lactam-polyol-polyacyl lactam or -acyl polylactam terpolymers have desirable anti-static properties with the improvement resulting from the presence of the polyol content of the said terpolymer. Such fibers are useful for carpeting, draperies, apparel and nonwoven fabrics.
    Type: Grant
    Filed: December 27, 1977
    Date of Patent: April 10, 1979
    Assignee: Monsanto Company
    Inventors: Kai-Lim W. Yung, Bernard Silverman, Virginia C. Menikheim
  • Patent number: 4075383
    Abstract: The method of pattern bonding nonwoven webs made from polyamide filaments wherein the web is exposed in a first treatment zone to a gaseous mixture of an activating agent and water and is then exposed in a second treatment zone to a wet atmosphere to allow the web to absorb enough additional moisture so that the web becomes essentially unbondable when pressed at room temperature. The web is then passed between a pair of rolls, at least one of which is embossed or engraved and heated to a sufficient temperature to autogenously bond discrete portions of the web while leaving the remainder of the web essentially unbonded. The high molar ratio of water to activating agent in the outer portions of the filaments in the web will prevent bonding of the web in those areas not contacted by the embossed roll, so that the web will have a high tenacity plus good drape and hand characteristics.
    Type: Grant
    Filed: April 15, 1976
    Date of Patent: February 21, 1978
    Assignee: Monsanto Company
    Inventors: Richard M. Anderson, Alton L. Caviness, Virginia C. Menikheim, Bernard Silverman