Patents by Inventor Bernard Silverman
Bernard Silverman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200345718Abstract: The instant application relates to morphinan derivatives of Formula I with sustained effectiveness in treating drug toxicity and overdose:Type: ApplicationFiled: February 7, 2020Publication date: November 5, 2020Inventors: Bernard Silverman, Fen-Ni Fu, Chengyun Guo
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Patent number: 10046052Abstract: Methods and dosage formulations for the safe treatment of cold, cough, flu, and sinus symptoms in children and adolescents by age and nature of symptoms, and adults and the elderly by age, nature of symptoms, and concomitant patient medical conditions. The method of the present invention comprises the formulation of a cold medication which consists essentially of combinations of a nonsedating or minimally sedating antihistamines with pain relievers and the expectorant, guaifenesin.Type: GrantFiled: May 16, 2011Date of Patent: August 14, 2018Inventor: Bernard Silverman
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Publication number: 20170333422Abstract: The instant application relates to morphinan derivatives of Formula I with sustained effectiveness in treating drug toxicity and overdose:Type: ApplicationFiled: June 5, 2017Publication date: November 23, 2017Inventors: Bernard Silverman, Fen-Ni Fu, Chengyun Guo
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Publication number: 20160051535Abstract: The instant application relates to morphinan derivatives of Formula I with sustained effectiveness in treating drug toxicity and overdose:Type: ApplicationFiled: August 25, 2015Publication date: February 25, 2016Inventors: Bernard Silverman, Fen-Ni Fu, Chengyun Guo
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Patent number: 9119848Abstract: The instant application relates to morphinan derivatives of Formula I with sustained effectiveness in treating drug toxicity and overdose:Type: GrantFiled: October 13, 2010Date of Patent: September 1, 2015Assignee: Alkermes Pharma Ireland LimitedInventors: Bernard Silverman, Fen-Ni Fu, Chengyun Guo
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Publication number: 20120245193Abstract: The present invention relates to a novel functional peripherally-acting ? opioid receptor antagonist of Formula I: The novel compounds of the present invention have reduced oral bioavailability without compromising opiate-induced analgesia in the CNS. The compounds of the present invention are further efficacious at low doses and are useful in treating gastrointestinal conditions associated with opioid analgesic therapy.Type: ApplicationFiled: February 14, 2012Publication date: September 27, 2012Inventors: Bernard Silverman, Mark Todtenkopf, Daniel Deaver, Lauren DiPetrillo
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Publication number: 20110281892Abstract: Methods and dosage formulations for the safe treatment of cold, cough, flu, and sinus symptoms in children and adolescents by age and nature of symptoms, and adults and the elderly by age, nature of symptoms, and concomitant patient medical conditions. The method of the present invention comprises the formulation of a cold medication which consists essentially of combinations of a nonsedating or minimally sedating antihistamines with pain relievers and the expectorant, guaifenesin.Type: ApplicationFiled: May 16, 2011Publication date: November 17, 2011Inventor: Bernard Silverman
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Publication number: 20110136848Abstract: The instant application relates to morphinan derivatives of Formula I with sustained effectiveness in treating drug toxicity and overdose:Type: ApplicationFiled: October 13, 2010Publication date: June 9, 2011Inventor: Bernard Silverman
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Patent number: 5411795Abstract: A method for electroless deposition of metal onto a nonconductive surface of a substrate is disclosed. According to the method, the surface is contacted with a nonaqueous carrier polymer mixture comprising (a) an organic solvent, (b) a catalytic compound that is soluble in the solvent and contains a catalytic metal, and (c) a polymer or polymeric precursor that is soluble in the solvent and that can be formed into a polymeric film that retains its integrity at 200.degree. C. Excess solvent is removed from the surface to form a catalytic carrier polymer coating on the surface, the coating comprising catalytic compound adhered to a layer of carrier polymer adhered to the surface. The coating is activated to produce an activated catalytic carrier polymer coating on the surface, which is then contacted with an aqueous electroless plating mixture thereby to form a plated substrate having a film of metal over and adhered to the layer of carrier polymer.Type: GrantFiled: October 14, 1992Date of Patent: May 2, 1995Assignee: Monsanto CompanyInventor: Bernard Silverman
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Patent number: 5405842Abstract: A method for the treatment of asthma, particularly corticosteroid dependent asthma with "steroid sparing" effect, but without serious toxicities prevalent with common "steroid sparing" treatments and medications, comprising the oral administration, in efficacious doses, of sulfasalazine (SSZ) (5-([p-(2-pyridylsulfamoyl) phenyl]azo) salicylic acid) ##STR1## compounds having either the: ##STR2## moiety, or the: ##STR3## moiety. The SSZ and related compounds can be used as an adjuvant for corticosteroid treatments, which permits drastic reduction of the dosage levels of the corticosteroids with concomitant reduction of steroid side effects.Type: GrantFiled: January 28, 1994Date of Patent: April 11, 1995Inventor: Bernard A. Silverman
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Patent number: 4694039Abstract: Unsaturated oligomers and solutions thereof are stabilized with a trisubstituted urea to provide improved storage stability. The stabilized unsaturated oligomer solutions are useful in lactam polymerization processes which yield nylon block copolymers containing unsaturated oligomer segments. The unsaturated oligomers disclosed herein have at least 4 carbons and have pendant thereto at least one hydroxy, amine, epoxy, acyllactam, or acyllactam precursor group.Type: GrantFiled: November 6, 1986Date of Patent: September 15, 1987Assignee: DSM Rim Nylon V.O.F.Inventors: Edward H. Mottus, Ross M. Hedrick, Bernard Silverman
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Patent number: 4672085Abstract: Unsaturated oligomers and solutions thereof are stabilized with a trisubstituted urea to provide improved storage stability. The stabilized unsaturated oligomer solutions are useful in lactam polymerization processes which yield nylon block copolymers containing unsaturated oligomer segments. The unsaturated oligomers disclosed herein have at least 4 carbons and have pendant thereto at least one hydroxy, amine, epoxy, acyllactam, or acyllactam precursor group.Type: GrantFiled: March 26, 1986Date of Patent: June 9, 1987Assignee: DSM Rim Nylon VOFInventors: Edward H. Mottus, Ross M. Hedrick, Bernard Silverman
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Patent number: 4396452Abstract: Nonwoven point-bonded fabrics of improved softness are prepared by simultaneously heating and compressing spaced, discrete areas of a nonwoven, bondable fiber web containing an attenuating bonding liquid in excess of the minimum amount required to provide maximum fabric strength.Type: GrantFiled: December 21, 1978Date of Patent: August 2, 1983Assignee: Monsanto CompanyInventors: Virginia C. Menikheim, Bernard Silverman
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Patent number: 4306929Abstract: Nonwoven point-bonded fabrics of improved softness are prepared by simultaneously heating and compressing spaced, discrete areas of a nonwoven thermally bondable fiber web containing an attenuating liquid.Type: GrantFiled: December 1, 1980Date of Patent: December 22, 1981Assignee: Monsanto CompanyInventors: Virginia C. Menikheim, Bernard Silverman
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Patent number: 4168195Abstract: The method of autogenously bonding a nonwoven web made from polyamide filaments wherein the filaments contain 0.1 to 20 weight percent of an activating agent and sufficient moisture that the molar ratio of water to activating agent in the filaments is above the bonding limit, wherein the web is heated sufficiently to drive off enough water to reduce the molar ratio of water to agent to a value below the bonding limit and pressed to autogenously bond the filaments in the web. After pressing, the activating agent is desorbed from the web.Type: GrantFiled: September 1, 1977Date of Patent: September 18, 1979Assignee: Monsanto CompanyInventors: Richard M. Anderson, Alton L. Caviness, Virginia C. Menikheim, Bernard Silverman
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Patent number: 4164600Abstract: Melt blended fibers of lactam-polyol-polyacyl lactam or acyl polylactam terpolymers together with polyesters are thermally bonded at temperatures below the bonding temperatures of either the crystalline polyester or the terpolymer, resulting in thermally stable fabrics that have bond strength greater than the individual polyester or terpolymer webs bonded at the same temperature.Type: GrantFiled: December 27, 1977Date of Patent: August 14, 1979Assignee: Monsanto CompanyInventors: Kai-Lim W. Yung, Bernard Silverman, Virginia C. Menikheim
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Patent number: 4163819Abstract: The present invention relates to non-woven fabrics characterized by excellent drapeability, very pleasant handle and good tensile properties. The fabrics are made from melt blends of a polyamide together with lactam-polyol-polyacyl lactam or acyl-polylactam terpolymers.The production of the non-woven webs or fabrics from melt blended fibers of polyamide with lactam-polyol-polyacyl lactam or acyl-polylactam terpolymers is achieved by contact or thermal bonding of melt spun fibers. In one embodiment of the invention, the webs are formed from fibers in the nascent condition as freshly extruded, e.g., they are substantially amorphous. Such amorphous fibers are readily bonded even at room temperature, resulting in autogenous self-bonding, with only little pressure being imposed. If desired these fibers may be bonded at temperatures of up to 210.degree. C.Type: GrantFiled: December 27, 1977Date of Patent: August 7, 1979Assignee: Monsanto CompanyInventors: Kai-Lim W. Yung, Bernard Silverman
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Patent number: 4148960Abstract: Melt blended shaped objects, fibers and fabrics of polyesters with lactam-polyol-polyacyl lactam or -acyl polylactam terpolymers have desirable anti-static properties with the improvement resulting from the presence of the polyol content of the said terpolymer. Such fibers are useful for carpeting, draperies, apparel and nonwoven fabrics.Type: GrantFiled: December 27, 1977Date of Patent: April 10, 1979Assignee: Monsanto CompanyInventors: Kai-Lim W. Yung, Bernard Silverman, Virginia C. Menikheim
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Patent number: 4075383Abstract: The method of pattern bonding nonwoven webs made from polyamide filaments wherein the web is exposed in a first treatment zone to a gaseous mixture of an activating agent and water and is then exposed in a second treatment zone to a wet atmosphere to allow the web to absorb enough additional moisture so that the web becomes essentially unbondable when pressed at room temperature. The web is then passed between a pair of rolls, at least one of which is embossed or engraved and heated to a sufficient temperature to autogenously bond discrete portions of the web while leaving the remainder of the web essentially unbonded. The high molar ratio of water to activating agent in the outer portions of the filaments in the web will prevent bonding of the web in those areas not contacted by the embossed roll, so that the web will have a high tenacity plus good drape and hand characteristics.Type: GrantFiled: April 15, 1976Date of Patent: February 21, 1978Assignee: Monsanto CompanyInventors: Richard M. Anderson, Alton L. Caviness, Virginia C. Menikheim, Bernard Silverman